Abstract
Among the offspring of obese women, macrosomia is a common complication. The modern epidemic of obesity is leading toward a higher incidence of macrosomic infants. In obese pregnant women, there is an increased supply of nutrients toward the fetus, leading to increased fat stores and hyperinsulinism. In these infants, after birth, the abrupt interruption of nutrient supply increases the risk of neonatal hypoglycemia with potentially deleterious consequences for the developing brain.
Keywords
Beta Cell Fetal Growth Plasma Glucose Level Neonatal Hypoglycemia Obese Pregnant Woman
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
- Akinbi HT, Gerdes JS (1995) Macrosomic infants of nondiabetic mothers and elevated C-peptide levels in cord blood. J Pediatr 127:481–484PubMedCrossRefGoogle Scholar
- Ben-Haroush A, Chen RH, Yogev Y (2009) Maternal obesity is a major risk factor for large-for-gestational-infants in pregnancies complicated by gestational diabetes. Arch Gynecol Obstet 279:539–543PubMedCrossRefGoogle Scholar
- Bonet B, Brunzell JD, Gown AM, Knopp RH (1992) Metabolism of very-low-density lipoprotein triglyceride by human placental cells: the role of lipoprotein lipase. Metabolism 41:596–603PubMedCrossRefGoogle Scholar
- Boney CM, Verma A, Tucker R, Vohr BR (2005) Metabolic syndrome in childhood: association with birth weight, maternal obesity and gestational diabetes mellitus. Pediatrics 115:e290–e296PubMedCrossRefGoogle Scholar
- Boyd EM (1934) The lipemia of pregnancy. J Clin Invest 13:347–363PubMedCrossRefGoogle Scholar
- Burns CM, Rutherford MA, Boardman JP et al (2008) Patterns of cerebral injury and neurodevelopment outcomes after symptomatic neonatal hypoglycemia. Pediatrics 122:65–74PubMedCrossRefGoogle Scholar
- Catalano PM, Tyzbir ED, Roman NM et al (1991) Longitudinal changes in insulin release and insulin resistance in nonobese pregnant women. Am J Obstet Gynecol 165:1667–1672PubMedGoogle Scholar
- Catalano PM, Houton L, Amini SB, Kalhan SC (1999) Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus. Am J Obstet Gynecol 180:903–913PubMedCrossRefGoogle Scholar
- Chase HP, Marlow RA, Dabiere CS, Welch NN (1973) Hypoglycemia and brain development. Pediatrics 52:513–520PubMedGoogle Scholar
- Coleman RA (1989) The role of the placenta in lipid metabolism and transport. Semin Perinatol 13:180–191PubMedGoogle Scholar
- Cornblath M, Reisner SH (1965) Blood glucose in the neonate and its clinical significance. N Engl J Med 273:378–381PubMedCrossRefGoogle Scholar
- Cowet RM (1999) Neonatal hypoglycemia: a little goes a long way. J Pediatr 134:389–391CrossRefGoogle Scholar
- Cowett RM, Farrag HM (1998) Neonatal glucose metabolism. In: Cowet RM (ed) Principles of perinatal-neonatal metabolism. Springer, New YorkCrossRefGoogle Scholar
- Di Cianni G, Miccoli R, Volpe L et al (2005) Maternal triglycerides levels and newborn weight in pregnant women with normal glucose tolerance. Diabet Med 22:21–25PubMedCrossRefGoogle Scholar
- Duvanel CB, Fawer CL, Cotting J et al (1999) Long-term effects of neonatal hypoglycaemia on brain growth and psychomotor development in small-for-gestational-age preterm infants. J Pediatr 134:492–498PubMedCrossRefGoogle Scholar
- Fraser A, Tilling K, Macdonald-Wallis C et al (2010) Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood. Circulation 121:2557–2564PubMedCrossRefGoogle Scholar
- Freinkel N (1980) Banting lecture: of pregnancy and progeny. Diabetes 29:1023–1035PubMedCrossRefGoogle Scholar
- Gillman MW, Rifas-Shiman S, Berkey CS et al (2003) Maternal gestational diabetes, birth weight, and adolescent obesity. Pediatrics 111:e221–e226PubMedCrossRefGoogle Scholar
- Herrera E, Bonet B, Lasuncion MA (1998) Maternal-fetal transfer of lipid metabolites. In: Polin RA, Fox WW (eds) Fetal and neonatal physiology. WB Saunders Company, PhiladelphiaGoogle Scholar
- Hoegsberg B, Gruppuso PA, Coustan DR (1993) Hyperinsulinemia in macrosomic infants of nondiabetic mothers. Diabetes Care 16:32–36PubMedCrossRefGoogle Scholar
- Khan BB, Flier JS (2004) Obesity and insulin resistance. J Clin Invest 106:473–481CrossRefGoogle Scholar
- Kliegman RM, Gross T (1985) Perinatal problems of the obese mother and her infant. Obstet Gynecol 66:299–306PubMedGoogle Scholar
- Knopp RH, Montes A, Childs M et al (1981) Metabolic adjustments in normal and diabetic pregnancy. Clin Obstet Gynecol 24:21–49PubMedCrossRefGoogle Scholar
- Knopp RH, Bonet B, Lasuncion MA et al (1992a) Lipoprotein metabolism in pregnancy. In: Herrera E, Knopp RN (eds) Perinatal biochemistry. CRC Press, Boca RatonGoogle Scholar
- Knopp RH, Magee MS, Walden CE et al (1992b) Prediction of infant birth weight by GDM screening test. Importance of plasma triglyceride. Diabetes Care 15:1605–1613PubMedCrossRefGoogle Scholar
- Knopp RH, Bonet B, Zhu XD (1998) Lipid metabolism in pregnancy. In Richard M Cowett (ed). Principles of Perinatal-Neonatal Metabolism, 2 nd edn. Springer, New YorkGoogle Scholar
- Metzger BE, Persen B, Lowe LP et al (2010) Hyperglycemia and adverse pregnancy outcome study: neonatal glycemia. Pediatrics 126:e1545–e1552PubMedCrossRefGoogle Scholar
- Ogata ES (1986) Carbohydrate metabolism in the fetus and neonate and altered neonatal glucoregulation. Pediatr Clin North Am 33:25–41PubMedGoogle Scholar
- Ogden CL, Carroll MD, Curtin LR et al (2011) Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 295:1549–1555CrossRefGoogle Scholar
- Olefsky JM (1997) Insulin resistance. In: Porte D, Sherwin RS (eds) Diabetes mellitus. Appleton & Lange, StamfordGoogle Scholar
- Osler M, Pedersen J (1960) The body composition of newborn in infants of diabetic mothers. Pediatrics 26:985–992PubMedGoogle Scholar
- Owens LA, O’Sullivan EP, Kirwan B et al (2010) ATLANTIC DIP: the impact of obesity on pregnancy outcome in glucose-tolerant women. Diabetes Care 33:577–579PubMedCrossRefGoogle Scholar
- Pedersen J (1952) Diabetes and pregnancy. Blood sugar of newborn infants. PhD thesis, Danish Science Press, CopenhagenGoogle Scholar
- Peters JP, Heinemann M, Man EB (1951) The lipids of serum in pregnancy. J Clin Invest 30:388–394PubMedCrossRefGoogle Scholar
- Robinson HE, O’Connell CM, Joseph KS, McLeod NM (2005) Maternal outcomes in pregnancies complicate by obesity. Obstet Gynecol 106:1357–1364PubMedCrossRefGoogle Scholar
- Rozance PJ, Hay WW (2006) Hypoglycemia in newborn infants: features associated with adverse outcomes. Biol Neonate 90:74–86PubMedCrossRefGoogle Scholar
- Ryan EA, O’Sullivan MJ, Skyler JS (1985) Insulin action during pregnancy. Studies with the euglycemic clamp technique. Diabetes 34:380–389PubMedCrossRefGoogle Scholar
- Sanchez-Vera I, Bonet B, Viana M et al (2005) Increased low-density lipoprotein susceptibility to oxidation in pregnancies and fetal growth restriction. Obstet Gynecol 106:345–351PubMedCrossRefGoogle Scholar
- Sivan E, Homko CJ, Chen X, Reece EA, Boden G (1999) Effect of insulin on fat metabolism during and after normal pregnancy. Diabetes 48:834–838PubMedCrossRefGoogle Scholar
- Srinivasan G, Pildes RS, Cattamanchi G et al (1986) Plasma glucose values in normal neonates: a new look. J Pediatr 109:114–117PubMedCrossRefGoogle Scholar
- Stenninger E, Schollin J, Aman J (1991) Neonatal macrosomia and hypoglycaemia in children of mothers with insulin-treated gestational diabetes mellitus. Acta Paediatr Scand 80:1014–1018PubMedCrossRefGoogle Scholar
- The HAPO Study Cooperative Research Group (2008a) Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 358:1991–2002CrossRefGoogle Scholar
- The HAPO Study Cooperative Research Group (2008b) Hyperglycemia and adverse pregnancy outcome (HAPO) study. Association with neonatal anthropometrics. Diabetes 58:453–459CrossRefGoogle Scholar
- Wang Y, Beydoun MA (2007) The obesity epidemic in the United States-gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev 29:6–28PubMedCrossRefGoogle Scholar
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