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What Is the Contribution of Intraoperative Radiotherapy (IORT) in Tailoring Local Therapy in Primary or Recurrent Rectal Cancer?

  • Felipe A. Calvo
Chapter

Abstract

Combined modality therapy, preferably preoperative chemoradiation and radical surgery, is the standard of care for local treatment in patients with locally advanced rectal cancer. Local control is expected superior to 85% at 5 years. Intraoperative radiotherapy (IORT) is a high-quality radiation-boosting technique for dose-escalation purposes in limited anatomic regions evaluated and considered at risk at the time of surgical resection. In-field IORT recurrence rates are inferior to 5% in primary disease. The experience available using IORT as a component of treatment, both in primary and localized recurrent disease, is reviewed. Factors associated to topographic (in-field control/recurrence) pelvic results are discussed to potentially guide a tailored use of IORT according to local risk estimations.

Keywords

Rectal Cancer Total Mesorectal Excision Local Recurrence Rate Advanced Rectal Cancer Preoperative Chemoradiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of OncologyHospital General Universitario Gregorio MarañonMadridSpain

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