Advertisement

Soft Tissue and Bone

  • Peter Spieler
  • Matthias Rössle
Part of the Essentials of Diagnostic Pathology book series (ESSENTPATH)

Abstract

Various benign and intermediate lesions of soft tissues and bones are listed in the first section. Special interest topics are adipocytic tumors, fibroblastic/myofibroblastic lesions, muscle tumors, schwannoma, and Langerhans cell histiocytosis. A selection of sarcoma from soft tissue and bone is presented in the ‘malignant section’ including relevant immunocytochemical and molecular genetic tests.

Furthermore, the reader is referred to different chapters of this book containing cytologic description of additional malignant soft tissue tumors.

Two tables (17.1. and 17.3.) display diagnostic synopsis of benign and malignant soft tissue/chondro-osseous lesions regarding various architectural, cellular and extracellular features. Table 17.2. compares age groups, gender preference, common locations, and differential diagnostic spectra of the benign/intermediate tumor entities listed in Table 17.1.

Keywords

Malignant Peripheral Nerve Sheath Tumor Giant Cell Tumor Aneurysmal Bone Cyst Epithelioid Sarcoma Clear Cell Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Further Reading

Further Reading (Sect. 17.1)

  1. 1.
    Akerman M, Rydholm A. Aspiration cytology of lipomatous tumors: a 10-year experience at an orthopedic oncology center. Diagn Cytopathol 1987;3:295-302.PubMedCrossRefGoogle Scholar
  2. 2.
    Batra VV, Jain S, Singh DK, Kumar N. Cytomorphologic spectrum of giant cell tumor of tendon sheath. Acta Cytol 2008;52:152-158.PubMedCrossRefGoogle Scholar
  3. 3.
    Beal M, Mayerson J, Wakely PE Jr. Fine-needle aspiration cytology of giant cell tumor of soft tissue (soft tissue giant cell tumor of low malignant potential). Ann Diagn Pathol 2003;7:365-369.PubMedCrossRefGoogle Scholar
  4. 4.
    Bechan GI, Egeler RM,Arceci RJ. Biology of Langerhans cells and Langerhans cell histiocytosis. Int Rev Cytol 2006;254:1-43.PubMedCrossRefGoogle Scholar
  5. 5.
    Bouloc A, Boulland ML, Geissmann F, et al. CD101 expression by Langerhans cell histiocytosis cells. Histopathology 2000;36:229-232.PubMedCrossRefGoogle Scholar
  6. 6.
    Cabrera RA, Almeida M, Mendoca ME, Frable WJ. Diagnostic pitfalls in fine-needle aspiration cytology of temporomandibular chondroblastoma: report of two cases. Diagn Cytopathol 2006;34: 424-429.PubMedCrossRefGoogle Scholar
  7. 7.
    Chhieng DC, Cangiarella JF, Waisman J, et al. Fine-needle aspiration cytology of spindle cell lesions of the breast. Cancer 1999;87:359-371.PubMedCrossRefGoogle Scholar
  8. 8.
    Creager AJ, Madden CR, Bergman S, Geisinger KR. Aneurysmal bone cyst: fine-needle aspiration findings in 23 patients with clinical and radiologic correlation. Am J Clin Pathol 2007;128:740-745.PubMedCrossRefGoogle Scholar
  9. 9.
    Dahl I, Akerman M. Nodular fasciitis a correlative cytologic and histologic study of 13 cases. Acta cytol 1981;25:215-223.PubMedGoogle Scholar
  10. 10.
    Dalal KM, Antonescu CR, Singer S. Diagnosis and management of lipomatous tumors. J Surg Oncol 2008;97:298-313.PubMedCrossRefGoogle Scholar
  11. 11.
    Dalen BP, Mels-Kindblom JM, Sumathi VP, et al. Fine-needle aspiration cytology and core needle biopsy in the preoperative diagnosis of desmoid tumors. Acta Orthop 2006;77:926-931.PubMedCrossRefGoogle Scholar
  12. 12.
    Dey P. Fine needle aspiration cytology of well-differentiated liposarcoma. A report of two cases. Acta Cytol 2000;44:459-462.PubMedCrossRefGoogle Scholar
  13. 13.
    Dodd LG, Martinez S. Fine-needle aspiration cytology of pseudosarcomatous lesions of soft tissue. Diagn Cytopathol 2001;24:28-35.PubMedCrossRefGoogle Scholar
  14. 14.
    Domanski HA. Fine-needle aspiration cytology of soft tissue lesions: diagnostic challenges. Diagn Cytopathol 2007;35:768-773.PubMedCrossRefGoogle Scholar
  15. 15.
    Domanski HA, Dawikiba S. Adult rhabdomyoma in fine needle aspirates. A report of two cases. Acta Cytol 2000;44:223-226.PubMedCrossRefGoogle Scholar
  16. 16.
    Domanski HA, Akerman M, Engellau J, et al. Fine-needle aspiration of neurilemoma (schwannoma). A clinicopathologic study of 116 patients. Diagn Cytopathol 2006;34:403-412.PubMedCrossRefGoogle Scholar
  17. 17.
    Domanski HA, Carlen B, Jonsson K, et al. Distinct cytologic features of spindle cell lipoma. A cytologic-histologic study with clinical, radiologic, electron microscopic, and cytogenetic correlations. Cancer 2001;25:93:381-389.CrossRefGoogle Scholar
  18. 18.
    Edel G, Ueda Y, Nakanishi J, et al. Chondroblastoma of bone. A clinical, radiological, light and immunohistochemical study. Virchows Arch A Pathol Anat Histopathol 1992;421:355-366.PubMedCrossRefGoogle Scholar
  19. 19.
    el-Jabbour JN, Wilson GD, Bennett MH, et al. Flow cytometric study of nodular fasciitis, proliferative fasciitis, and proliferative myositis. Hum Pathol 1991;22:1146-1149.PubMedCrossRefGoogle Scholar
  20. 20.
    Estrada-Villasenor E, Cedillo ED, Martinez GR. Scrape cytology of myositis ossificans: Report of a case and analysis of the cytologic findings described previously. Diagn Cytopathol 2008;36:50-53.PubMedCrossRefGoogle Scholar
  21. 21.
    Fanburg-Smith JC, Majidi M, Miettinen M. Keratin expression in schwannoma; a study of 115 retroperitoneal and 22 peripheral schwannomas. Mod Pathol 2006;19:115-121.PubMedCrossRefGoogle Scholar
  22. 22.
    Fletcher CDM, Unni KK, Mertens F (Eds.). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press: Lyon 2002.Google Scholar
  23. 23.
    Furlong MA, Fanburg-Smith JC, Miettinen M. The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol 2001;25:809-814.PubMedCrossRefGoogle Scholar
  24. 24.
    Gonzalez-Campora R. Cytoarchitectural findings in the diagnosis of primary soft tissue tumors. Acta Cytol 2001;45:115-146.PubMedCrossRefGoogle Scholar
  25. 25.
    Granados R, Martin-Hita A, Rodriguez-Barbero JM, Murillo N. Fine-needle aspiration cytology of chondroblastoma of soft parts: case report and differential diagnosis with other soft tissue tumors. Diagn Cytopathol 2003;28:76-81.PubMedCrossRefGoogle Scholar
  26. 26.
    Guo Z, Voytovich M, Kurtycz DF, Hoerl HD. Fine-needle aspiration diagnosis of spindle-cell lipoma: a case report and review of the literature. Diagn Cytopathol 2000;23:362-365.PubMedCrossRefGoogle Scholar
  27. 27.
    Gupta K, Dey P, Goldsmith R, Vasishta RK. Comparison of cytologic features of giant-cell tumor and giant-cell tumor of tendon sheath. Diagn Cytopathol 2004;30:14-18.PubMedCrossRefGoogle Scholar
  28. 28.
    Hajdu SI, Hajdu EO. Cytopathology of Soft Tissue and Bone Tumors. Basel, S Karger 1989.Google Scholar
  29. 29.
    Handa U, Palta A, Mohan H, Punia RP. Aspiration cytology of glomus tumor: a case report. Acta Cytol 2001;45:1073-1076.PubMedCrossRefGoogle Scholar
  30. 30.
    Hashimoto CH, Cobb CJ. Cytodiagnosis of hibernoma: a case rport. Diagn Cytopathol 1987;3:326-329.PubMedCrossRefGoogle Scholar
  31. 31.
    Holck S, Bredesen JL. Solid glomus tumor presenting as an axillary mass: report of a case with morphologic study, including cytologic characteristics. Acta Cytol 1996;40:555-562.PubMedCrossRefGoogle Scholar
  32. 32.
    Hong R, Choi DY, Do NY, Lim SC. Fine-needle aspiration cytology of a lipoblastoma: a case report. Diagn Cytopathol 2008;36:508-511.PubMedCrossRefGoogle Scholar
  33. 33.
    Howarth DM, Gilchrist GS, Mullan BP, et al. Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome. Cancer 1999;85:2278-2290.PubMedCrossRefGoogle Scholar
  34. 34.
    Icihikawa K, Tanino R. Soft tissue giant cell tumor of low malignant potential. Tokai J Exp Clin med 2004;29:91-95.PubMedGoogle Scholar
  35. 35.
    Jain M, Aiyer HM, Singh M, Narula M. Fine-needle aspiration diagnosis of giant cell tumor of bone presenting at unusual sites. Diagn Cytopathol 2002;27:375-378.PubMedCrossRefGoogle Scholar
  36. 36.
    Jain M, Kaur M, Kapoor S,Arora DS. Cytological features of chondroblastoma: a case report with review of the literature. Diagn Cytopathol 2000;23:348-350.PubMedCrossRefGoogle Scholar
  37. 37.
    Kapila K, Ghosal N, Gill SS, Verma K. Cytomorphology of lipomatous tumors of soft tissue. Acta Cytol 2003;47:555-562.PubMedCrossRefGoogle Scholar
  38. 38.
    Kim NR, Han J. Primary giant cell tumor of soft tissue. Report of a case with fine needle aspiration cytologic and histologic findings. Acta Cytol 2003;47:1103-1106.PubMedCrossRefGoogle Scholar
  39. 39.
    Kindblom LG, Meis-Kindblom JM. Chondroid lipoma: an ultrastructural and immunohistochemical analysis with further observations regarding its differentiation. Hum Pathol 1995;26:706-715.PubMedCrossRefGoogle Scholar
  40. 40.
    Kitsoulis P, Galani V, Stefanaki K, et al. Osteochondromas: review of the clinical, radiological and pathological features. InVivo 2008;22:633-646.Google Scholar
  41. 41.
    Klijanienko J, Caillaud JM, Lagacé R. Fine-needle aspiration in liposarcoma: cytohistologic correlative study including well-differentiated, myxoid, and pleomorphic variants. Diagn Cytopathol 2004;30:307-312.PubMedCrossRefGoogle Scholar
  42. 42.
    Klijanienko J, Caillaud JM, Lagacé R. Cytohistologic correlations in schwannomas (neurilemomas), including „ancient“, cellular, and epithelioid variants. Diagn Cytopathol 2006;34:517-522.PubMedCrossRefGoogle Scholar
  43. 43.
    Knoeller SM, Uhl M, Adler CP, Herget GW. Differential diagnosis of benign tumors and tumor-like lesions in the spine. Own cases and review of the literature. Neoplasma 2004;51:117-126.PubMedGoogle Scholar
  44. 44.
    Kong CS, Cha I. Nodular fasciitis: diagnosis by fine needle aspiration biopsy. Acta Cytol 2004;48:473-477.PubMedCrossRefGoogle Scholar
  45. 45.
    Kumar S, Chowdhury N. Accuracy, limitations and pitfalls in the diagnosis of soft tissue tumors by fine needle aspiration cytology. Indian J Pathol Microbiol 2007;50:42-45.PubMedGoogle Scholar
  46. 46.
    Lemos MM, Kindblom LG, Meis-Kindblom JM, et al. Fine-needle aspiration characteristics of hibernoma. Cancer 2001;93:206-210.PubMedCrossRefGoogle Scholar
  47. 47.
    Lopez-Ferrer P, Jimenez-Heffernan JA, Yebenes L, et al. Fineneedle aspiration cytology of lipoblastoma: a report of two cases. Diagn Cytopathol 2005;32:32-34.PubMedCrossRefGoogle Scholar
  48. 48.
    MacSweeney F, Desai SA. Inflammatory pseudotumour of the subcutis: a report on the fine needle aspiration findings in a case misdiagnosed cytologically as malignant. Cytopathology 2000;11:57-60.PubMedCrossRefGoogle Scholar
  49. 49.
    McGregor DK, Krishnan B, Green L. Fine-needle aspiration of adult rhabdomyoma: a case report with review of the literature. Diagn Cytopathol 2003;28:92-95.PubMedCrossRefGoogle Scholar
  50. 50.
    Mentzel T, Remmler K, Katenkamp D. Chondroid lipoma. Clinicopathological, immunohistochemical, and ultrastructural analysis of six cases of a distinct entity in the spectrum of lipomas. Pathologe 1999;20:330-334.PubMedCrossRefGoogle Scholar
  51. 51.
    Morerio C, Nozza P, Tassano E, et al. Differential diagnosis of lipoma-like lipoblastoma. Pediatr Blood Cancer 2009;52:132-134.PubMedCrossRefGoogle Scholar
  52. 52.
    Ooe M, Ishiguro N, Kawashima M. Nuclear DNA content and distribution of Ki-67 positive cells in nodular fasciitis. J Dermatol 1993;20:214-218.PubMedGoogle Scholar
  53. 53.
    Ostrowski ML, Johnson ME, Truong LD, et al. Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy Skeletal Radiol 1999;28:644-650.PubMedCrossRefGoogle Scholar
  54. 54.
    Owens CL, Sharma R, Ali SZ. Deep fibromatosis (desmoid tumor): cytopathologic characteristics, clinicoradiologic features, and immunohistochemical findings on fine-needle aspiration. Cancer 2007;111:166-172.PubMedCrossRefGoogle Scholar
  55. 55.
    Pavlovic S, Valyi-Nagy T, Profirovic J, David O. Fine-needle aspiration of brown tumor of bone: cytologic features with radiologic and histologic correlation. Diagn Cytopathol 2009;37:136-139.PubMedCrossRefGoogle Scholar
  56. 56.
    Raab SS, Silverman JF, McLeod DL, et al. Fine needle aspiration biopsy of fibromatoses. Acta Cytol 1993;37:323-328.PubMedGoogle Scholar
  57. 57.
    Rigby HS, Wilson YG, Cawthorn SJ, Ibrahim NB. Fine needle aspiration of pleomorphic lipoma: a potential pitfall of cytodiagnosis. Cytopathology 1993;4:55-58.PubMedCrossRefGoogle Scholar
  58. 58.
    Roux S. Giant cell tumors of bone. Rev Rhum Engl Ed 1998;65:139-147.PubMedGoogle Scholar
  59. 59.
    Saikia B, Goel A, Gupta SK. Fine-needle aspiration cytologic diagnosis of giant-cell tumor of the sacrum presenting as a rectal mass: a case report. Diagn Cytopathol 2001;24:39-41.PubMedCrossRefGoogle Scholar
  60. 60.
    Semmelink HJ, Pruszczynski M, Wiersma-van Tilburg A, et al. Cytokeratin expression in chondroblastomas. Histopathology 1990;16:257-263.PubMedCrossRefGoogle Scholar
  61. 61.
    Shattuck MC, Victor TA. Cytologic features of well-differentiated sclerosing liposarcoma in aspirated samples. Acta Cytol 1988;32: 896-901.PubMedGoogle Scholar
  62. 62.
    Shukla S, Sharma S, Langer S, Sinha M. FNAC of inflammatory myofibroblastic tumour of the subcutis: a diagnostic dilemma. Indian J Pathol Microbiol 2007;50:875-877.PubMedGoogle Scholar
  63. 63.
    Singh HK, Kilpatrick SE, Silverman JF. Fine needle aspiration biopsy of soft tissue sarcomas: utility and diagnostic challenges. Adv Anat Pathol 2004;11:24-37.PubMedCrossRefGoogle Scholar
  64. 64.
    Vetrani A, Fulciniti F, Boschi R, et al. Fine needle aspiration biopsy diagnosis of giant-cell tumor of bone. An experience with nine cases. Acta Cytol 1990;34:863-867.PubMedGoogle Scholar
  65. 65.
    Wakely PE, Almeida M, Frable WJ. Fine-needle aspiration biopsy cytology of myositis ossificans. Mod Pathol 1994;7:23-25.PubMedGoogle Scholar
  66. 66.
    Walaas L, Kindblom LG. Lipomatous tumors: a correlative cytologic and histologic study of 27 tumors examined by fine needle aspiration cytology. Hum Pathol 1985;16:6-18.PubMedCrossRefGoogle Scholar
  67. 67.
    Walsh SN, Hurt MA. Cutaneous fetal rhabdomyoma: a case report and historical review of the literature. Am J Surg Pathol 2008;32: 485-491.PubMedCrossRefGoogle Scholar
  68. 68.
    Ward WG, Savage P, Boles CA, Kilpatrick SE. Fine-needle aspiration biopsy of sarcomas and related tumors. Cancer Control 2001;8:232-238.PubMedGoogle Scholar
  69. 69.
    Weiss SW. Lipomatous tumors. Monogr Pathol 1996;38:207-239.PubMedGoogle Scholar
  70. 70.
    Weiss SW, Goldblum JR (eds) (2007), Enzinger and Weiss’s Soft Tissue Tumors, 5th rev. ed, MosbyGoogle Scholar
  71. 71.
    Willman CL, McClain KL. An update on clonality, cytokines, and viral etiology in Langerhans cell histiocytosis. Hematol Oncol Clin North Am 1998;12:407-416.PubMedCrossRefGoogle Scholar
  72. 72.
    Wong NL. Fine needle aspiration cytology of pseudosarcomatous reactive proliferative lesions of soft tissue. Acta Cytol 2002;46: 1049-1055.PubMedCrossRefGoogle Scholar
  73. 73.
    Woyke S, Kapila K, Goswami KC. Atypical lipoma as a potential pitfall in the cytodiagnosis of subcutaneous tumors. A report of two cases. Acta Cytol 1997;41:897-902.PubMedCrossRefGoogle Scholar
  74. 74.
    Yadavrao KA, Rajaram DS, Vijaykumar WJ, Langade YB. Fine needle aspiration cytology diagnosis of aneurysmal bone cyst: a case report. Indian J Pathol Microbiol 2007;50:425-426.PubMedGoogle Scholar
  75. 75.
    Yamamoto T, Nagira K, Akisue T, et al. Fine-needle aspiration biopsy of solid aneurysmal bone cyst in the humerus. Diagn Cytopathol 2003;28:159-162.PubMedCrossRefGoogle Scholar
  76. 76.
    Yong M, Raza AS, Greaves TS, Cobb CJ. Fine-needle aspiration of a pleomorphic lipoma of the head and neck: a case report. Diagn Cytopathol 2005;32:110-113.PubMedCrossRefGoogle Scholar
  77. 77.
    Zhu H, Hu DX. Langerhans cell histiocytosis of the thyroid diagnosed by fine needle aspiration cytology. A case report. Acta Cytol 2004;48:278-280.PubMedCrossRefGoogle Scholar

Further Reading (Sect. 17.2)

  1. 1.
    Akerman M, Domanski HA. The cytology of soft tissue tumours. Monogr Clin Cytol 2003;16:IX-X,1-112.Google Scholar
  2. 2.
    Coindre JM. Grading of soft tissue sarcomas: review and update. Arch Pathol Lab Med 2006;130:1448-1453.PubMedGoogle Scholar
  3. 3.
    Conley AP, Trent J, Zhang W. Recent progress in the genomics of soft tissue sarcomas. Curr Opin Oncol 2008;20:395-399.PubMedCrossRefGoogle Scholar
  4. 4.
    Domanski HA. Fine-needle aspiration cytology of soft tissue lesions: diagnostic challenges. Diagn Cytopathol 2007;35:768-773.PubMedCrossRefGoogle Scholar
  5. 5.
    Fleshman R, Mayerson J, Wakely PE Jr. Fine-needle aspiration biopsy of high-grade sarcoma. A report of 107 cases. Cancer (Cancer Cytopathol) 2007;111:491-498.Google Scholar
  6. 6.
    Fletcher CD. The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology 2006;48:3-12.PubMedCrossRefGoogle Scholar
  7. 7.
    Fletcher CDM, Unni KK, Mertens F (Eds.). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft tissue and Bone. IARC Press: Lyon 2002.Google Scholar
  8. 8.
    Gonzalez-Campora R. Cytoarchitectural findings in the diagnosis of primary soft tissue tumors. Acta Cytol 2001;45:115-146.PubMedCrossRefGoogle Scholar
  9. 9.
    Hajdu SI, Hajdu EO. Cytopathology of Soft Tissue and Bone Tumors. Basel, S Karger 1989.Google Scholar
  10. 10.
    Kilpatrick SE, Geisinger KR. The usefulness and limitations of fine-needle aspiration biopsy. Am J Clin Pathol 1998;110:50-68.PubMedGoogle Scholar
  11. 11.
    Kilpatrick SE, Cappellari JO, Bos GD, et al. Is fine-needle aspiration biopsy a practical alternative to open biopsy for the primary diagnosis of sarcoma? Experience with140 patients. Am J Clin Pathol 2001;115:59-68.PubMedCrossRefGoogle Scholar
  12. 12.
    Kumar S, Chowdhury N. Accuracy, limitations and pitfalls in the diagnosis of soft tissue tumors by fine needle aspiration cytology. Indian J Pathol Microbiol 2007;50:42-45.PubMedGoogle Scholar
  13. 13.
    Layfield LJ. Cytologic diagnosis of osseous lesions: a review with emphasis on the diagnosis of primary neoplasms of bone. Diagn Cytopathol 2009;37:299-310.PubMedCrossRefGoogle Scholar
  14. 14.
    Mallik MK, Dey P, Gupta SK, Vasishta RK. Grading of soft tissue sarcomas on fine-needle aspiration cytology smear. Diagn Cytopathol 2009 Aug 17; Epub.Google Scholar
  15. 15.
    Oliveira AM, Nascimento AG. Grading of soft tissue tumors: principles and problems. Skeletal Radiol 2001;30:543-559.PubMedCrossRefGoogle Scholar
  16. 16.
    Palmer HE, Mukunyadzy P, Culbreth W, Thomas JR. Subgrouping and grading of soft-tissue sarcomas by fine-needle aspiration cytology: a histopathologic correlation study. Diagn Cytopathol 2001; 24:307-316.PubMedCrossRefGoogle Scholar
  17. 17.
    Singh HK, Kilpatrick SE, Silverman JF. Fine needle aspiration biopsy of soft tissue sarcomas: utility and diagnostic challenges. Adv Anat Pathol 2004;11:24-37.PubMedCrossRefGoogle Scholar
  18. 18.
    Wahane RN, Leie VR, Bobhate SK. Fine needle aspiration cytology of bone tumors. Acta Cytol 2007;51:711-720.PubMedCrossRefGoogle Scholar
  19. 19.
    Ward WG Sr, Kilpatrick S. Fine needle aspiration biopsy of primary bone tumors. Clin Orthop Relat Res 2000;373:80-87.CrossRefGoogle Scholar
  20. 20.
    Ward WG, Savage P, Boles CA, Kilpatrick SE. Fine-needle aspiration biopsy of sarcomas and related tumors. Cancer Control 2001;8:232-238.PubMedGoogle Scholar
  21. 21.
    Weiss SW, Goldblum JR (eds) (2007), Enzinger and Weiss’s Soft Tissue Tumors, 5th rev. ed, MosbyGoogle Scholar
  22. 22.
    Yang YJ, Damron TA. Comparison of needle core biopsy and fineneedle aspiration for diagnostic accuracy in musculosceletal lesions. Arch Pathol Lab Med 2004;128:759-764.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Peter Spieler
    • 1
  • Matthias Rössle
    • 2
  1. 1.Institut für PathologieKantonsspital St. GallenSt. GallenSwitzerland
  2. 2.Institut für Klinische PathologieUniversitätsSpital ZürichZürichSwitzerland

Personalised recommendations