Towards the Synthesis of Various Heteroaromatic Lipoxin A4 Analogues

  • Colm Duffy
Part of the Springer Theses book series (Springer Theses)


Our research group has successfully demonstrated that the introduction of benzene, pyridine and thiophene rings into the core Lipoxin structure has contributed to an enhancement of the biological profile of this class of eicosanoid. There is an on-going effort in the pharmaceutical industry to design and synthesise new drugs to combat existing inflammatory disorders. These novel stable LXA4 analogues possess the ability to aid the inflammation process and are therefore showing potential as therapeutic agents. Taking these recent advances into account, we have designed a series of novel heteroaryl LXA4 analogues, Fig. 6.1, with a view to further increasing the biological potency of these anti-inflammatory agents.


Thionyl Chloride Heck Reaction Oxalyl Chloride Aryl Bromide Aryl Chloride 
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Copyright information

© Springer-Verlag Berlin Heidelberg  2012

Authors and Affiliations

  1. 1.UCD School of Chemistry and Chemical Biology, Centre for Synthesis and Chemical BiologyUniversity College DublinBelfield, Dublin 4Ireland

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