Synthesis and Biological Evaluation of Pyridine-Containing Lipoxin A4 Analogues

  • Colm Duffy
Part of the Springer Theses book series (Springer Theses)


The development of stable LXA4 and LXB4 analogues which show resistance to enzymatic degradation is an on-going research goal in drug development.The development of stable LXA4 and LXB4 analogues which show resistance to enzymatic degradation is an on-going research goal in drug development. Efforts directed towards derivatisation of the triene system in particular have been inspired by the encouraging results obtained from the biological evaluation of our novel aromatic analogues [1], along with those of Petasis et al. [2, 3]. Rational replacement of this triene system has previously led to more stable derivatives, where enzymatic degradation is suppressed.


Chiral HPLC Structure Activity Relationship Study Heck Coupling Pyridinium Chlorochromate Aromatic Analogue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg  2012

Authors and Affiliations

  1. 1.UCD School of Chemistry and Chemical Biology, Centre for Synthesis and Chemical BiologyUniversity College DublinBelfield, Dublin 4Ireland

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