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Low Field NMR as a Tool for Neuronal Current Detection: A Feasibility Study in a Phantom

  • Rainer Körber
  • Nora Höfner
  • Martin Burghoff
  • Lutz Trahms
  • Jens Haueisen
  • Sven Martens
  • Gabriel Curio
Part of the Springer Proceedings in Physics book series (SPPHY, volume 140)

Abstract

The detection of neuronal currents (NC) may foster the understanding of the flow of information in the brain. Existing methods of NC detection like electro- and magnetoencephalography (EEG/MEG) are limited by the ambiguity of the inverse problem, while imaging methods like fMRI monitor secondary effects (e.g., blood oxygenation changes). On the other hand, attempts to directly detect NC in high field NMR techniques by a local shift of the 1H resonance frequency have yielded controversial results. In magnetic fields around 1 microTesla, the relative contribution of the biomagnetic field generated by neuronal currents is orders of magnitude higher than in conventional high fields. This may make the situation much more favourable.

Keywords

Larmor Frequency Local Shift Current Dipole Equivalent Current Dipole Magnetic Particle Image 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  • Rainer Körber
    • 1
  • Nora Höfner
    • 1
  • Martin Burghoff
    • 1
  • Lutz Trahms
    • 1
  • Jens Haueisen
    • 2
  • Sven Martens
    • 2
  • Gabriel Curio
    • 3
  1. 1.Physikalisch-Technische Bundesanstalt, BerlinBerlinGermany
  2. 2.Institut of Biomedical Engineering and InformaticsIlmenau University of TechnologyIlmenauGermany
  3. 3.Department of Neurology, Campus Benjamin FranklinCharité-Universitätsmedizin BerlinBerlinGermany

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