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Dendronized Iron Oxides as Smart Nano-objects for Multimodal Imaging

  • B. Basly
  • G. Popa
  • A. Garofalo
  • D. Felder-Flesch
  • S. Begin-Colin
  • C. Billotey
Part of the Springer Proceedings in Physics book series (SPPHY, volume 140)

Abstract

Superparamagnetic iron oxide nanoparticles (NPs) with appropriate surface coating are widely used for numerous in vivo applications and in particular for MRI contrast enhancement. To improve the contrast enhancement and targeting properties as well as the biodistribution of functionalized iron oxide NPs, challenges have to be overcome such as: (i) the design of an organic coating favouring ideal biodistribution, ensuring multifunctionalization (targeting, optical imaging…) and preserving a small size distribution of coated NPs in physiological media (<50 nm), (ii) the synthesis of iron oxide NPs with good magnetic properties and (iii) the development of strong anchors at the NPs surface avoiding desorption of molecules in blood. Indeed, the coating design as well as the interaction nature between the organic shell and the nanocrystal surface are more and more key points to address.

Keywords

Iron Oxide Colloidal Stability Multimodal Image Superparamagnetic Iron Oxide Nanoparticles Nanocrystal Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  • B. Basly
    • 1
  • G. Popa
    • 1
  • A. Garofalo
    • 1
  • D. Felder-Flesch
    • 1
  • S. Begin-Colin
    • 1
  • C. Billotey
    • 2
  1. 1.Institut of Physic and Chemistry of MaterialsUMR CNRS-Unistra 7504StrasbourgFrance
  2. 2.Laboratoire de Physico-chimie des MatériauxLuminescents LPCML-UCBL UMR 5620LyonFrance

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