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Citrate-Coated Magnetite Nanoparticles Are Highly Efficient Agents for Magnetic Labeling of Human Mesenchymal Stem Cells

  • Kristin Andreas
  • Jochen Ringe
  • Michael Sittinger
  • Norbert Buske
Part of the Springer Proceedings in Physics book series (SPPHY, volume 140)

Abstract

Motivation: Systemic transplantation of human mesenchymal stem- and progenitor cells (MSC) is a promising approach in regenerative medicine. Magnetic resonance imaging (MRI) of transplanted MSC labeled with superparamagnetic iron oxide nanoparticles (SPION) is an excellent tool for in vivo cell tracking because it offers a highspatio-temporal, sensitive and non-invasive cell detection. However, cell labeling with commercial SPION is still inefficient and requires the use of potentially toxic transfection agents. New results are reported here about magnetite@citrate ferrofluids that allow highly efficient magnetic MSC labeling without transfection agents.

Keywords

Prussian Blue Human Mesenchymal Stem Cell Couple Plasma Optical Emission Spectrometry Regenerative Therapy Cell Tracking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  • Kristin Andreas
    • 1
  • Jochen Ringe
    • 1
  • Michael Sittinger
    • 1
  • Norbert Buske
    • 2
  1. 1.Tissue Engineering Laboratory and Berlin-Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical ImmunologyCharité-Universitätsmedizin BerlinBerlinGermany
  2. 2.Magnetic FluidsBerlinGermany

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