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Mouse Bed Optimized for MPI

  • Matthias Weber
  • Patrick Goodwill
  • Steven Conolly
Part of the Springer Proceedings in Physics book series (SPPHY, volume 140)

Abstract

Magnetic particle imaging (MPI) is a new imaging modality, which allows for the determination of the distribution of super paramagnetic nanoparticles in vivo with excellent contrast, penetration and high temporal resolution. So far, real-time imaging in a mouse has been realized using a scanning-system with a field free point (FFP). Recently, an alternative encoding scheme has been developed promising faster scanning times and a higher sensitivity. This can be handled by extending the FFP to a field free line (FFL). Preliminary scans of phantoms showed the feasibility of the FFL in practice, based on projection x-space MPI. To ensure the safety of imaging switching from phantom to in vivo scans, a specific protocol has to be provided for scanning live animals. This paper describes the construction and testing of a mouse bed for heating as well as delivery and recovery of anesthesia gases. The mouse bed is constructed with non-magnetic materials and sized to the specific scanner. The size of the bed is limited by the diameter of the bore, and a larger bed (and bore) would be required for larger animals.

We designed a mouse bed fulfilling all mentioned requirements by engineering a specialized water warming system and a modified connection for the anesthesia system. The whole bed is moveable and rotatable in and around the longitudinal axis of the bore by jointing it to a robot. Rotation is critical for performing volumetric 3D MPI with projection reconstruction (or Radon) computerized tomography.

Keywords

Water Warming External Water Projection Reconstruction Anesthesia System Water Warming System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  • Matthias Weber
    • 1
  • Patrick Goodwill
    • 2
  • Steven Conolly
    • 2
  1. 1.Institute of Medical EngineeringUniversity of LuebeckLuebeckGermany
  2. 2.Department of Bioengineering and EECSUniversity of California BerkeleyBerkeleyUSA

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