Experimental 3D X-Space Magnetic Particle Imaging Using Projection Reconstruction

  • Justin Konkle
  • Patrick Goodwill
  • Oscar Carrasco-Zevallos
  • Steven Conolly
Part of the Springer Proceedings in Physics book series (SPPHY, volume 140)

Abstract

Tomographic imaging using a shifted and rotated field free line (FFL) with filtered backprojection image reconstruction can approach an order of magnitude SNR improvement over a field free point (FFP) given equal scan time. In this paper, we demonstrate a projection reconstruction x-space imager. The imager consists of a 2.4 T/m permanent magnet FFL gradient, a Helmholtz pair of off-the-shelf electromagnets, a solenoidal transmit coil and a gradiometer receive coil. A motor driven rotary table rotates the sample and the system acquires multiple projection images at evenly spaced angles between zero degrees and 180 degrees. Filtered back-projection is used to reconstruct a three-dimensional tomographic image stack. Sample rotation, which is sometimes employed in commercial mouse CT scanners, has been used to test this method. Later systems may rotate the gradient similar to a human-sized CT gantry or may generate an electronically rotated FFL gradient. In previous work, we have shown an MPI capable FFL scanner. Here, we show 3D experimental results of our PR-MPI scanner using acrylic USPIO imaging phantoms and post-mortem mice.

Keywords

Projection Image Imaging Phantom Rotary Table Projection Reconstruction NdFeB Magnet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Weizenecker, J., Gleich, B., Borgert, J.: Magnetic particle imaging using a field free line. Journal of Physics D: Applied Physics 41(10), 105009 (2008)CrossRefGoogle Scholar
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    Knopp, T., Erbe, M., Sattel, T.F., Biederer, S., Buzug, T.M.: A Fourier slice theorem for magnetic particle imaging using a field-free line. Inverse Problems 27(9), 095004 (2011)MathSciNetCrossRefGoogle Scholar
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    Konkle, J., Goodwill, P., Conolly, S.: Development of a field free line magnet for projection MPI. In: Proceedings of SPIE, vol. 7965, p. 79650X (2011)Google Scholar

Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  • Justin Konkle
    • 1
  • Patrick Goodwill
    • 1
  • Oscar Carrasco-Zevallos
    • 1
  • Steven Conolly
    • 1
    • 2
  1. 1.Department of BioengineeringUniversity of California, BerkeleyBerkeleyUSA
  2. 2.EECSUniversity of California, BerkeleyBerkeleyUSA

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