Advertisement

3D Semi-quantification of Nanoparticle Content in Tissue on Experimental and Commercial μCT-Scanner

  • Helene Rahn
  • Katharina Bayer
  • Stefan Odenbach
  • Stefan Lyer
  • Christoph Alexiou
  • Frank Wiekhorst
  • Lutz Trahms
  • Michael Baumann
  • Julia Buckwar
  • Mechthild Krause
Part of the Springer Proceedings in Physics book series (SPPHY, volume 140)

Abstract

X-ray computed tomography is a widely used imaging technique nowadays. Especially in medicine it takes an important role for visualization and diagnostics. Micro-computed tomography (μCT) follows the same principle as conventional medical CT-Scanner. But the objects analyzed are smaller, thus an improvement in spatial resolution down to few micrometers is possible. In the work field of biomedical application of magnetic nanoparticles μCT has been used for the visualization of the nanoparticle accumulations within tumoral regions after magnetic drug targeting. Further on, a calibration procedure has been developed and applied with a μCT-apparatus. The calibration procedure enables a semi-quantification of the nanoparticle content within the tissue samples. The next step stone in visualization process is the observation of the nanoparticle accumulation during the application of magnetic drug targeting in an animal. Thus, we have tested the calibration procedure on a commercial animal scanner. In this paper we compare the semi-quantitative results figured out in two different μCT-equipments.

Keywords

Magnetic Nanoparticles Calibration Procedure Magnetic Fluid Nanoparticle Concentration Nanoparticle Accumulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Alexiou, C., Arnold, W., Klein, R.J., Parak, F.G., Hulin, P., Bergemann, C., Erhardt, W., Wagenpfeil, S., Lübbe, A.S.: Locoregional cancer treatment with Magnetic Drug Targeting. Cancer Research 60, 6641–6648 (2000)Google Scholar
  2. 2.
    Rahn, H., Odenbach, S.: X-ray micro-tomography as tool for the investigation of the biodistribution of magnetic nanoparticles. Nanomedicine 4(8), 981–990 (2009)CrossRefGoogle Scholar
  3. 3.
    Brunke, O., Odenbach, S., Jurgons, R., Alexiou, C., Hilger, I., Beckmann, F.: J. Phys. Condens. Matter 18, S2903–S2917 (2006)CrossRefGoogle Scholar
  4. 4.
  5. 5.
    Rahn, H., Odenbach, S.: Calibration phantom for 3-dimensional semi-quantitative detection of nanoparticle content in biological tissue samples after magnetically supported cancer treatment (in Preparation)Google Scholar
  6. 6.
    Wiekhorst, F., et al.: Quantification of magnetic nanoparticles by magnetorelaxometry and comparison to histology after magnetic drug targeting. Journal of Nanoscience and Nanotechnology 6, 222–3225 (2006)CrossRefGoogle Scholar
  7. 7.

Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  • Helene Rahn
    • 1
  • Katharina Bayer
    • 1
  • Stefan Odenbach
    • 1
  • Stefan Lyer
    • 2
  • Christoph Alexiou
    • 2
  • Frank Wiekhorst
    • 3
  • Lutz Trahms
    • 3
  • Michael Baumann
    • 4
  • Julia Buckwar
    • 4
  • Mechthild Krause
    • 4
  1. 1.Institute of Fluid MechanicsMagnetofluiddynamics, UniversityDresdenGermany
  2. 2.Section for Experimental Oncology and Nanomedicine at the ENT-DepartmentThe University Erlangen-NürnbergErlangenGermany
  3. 3.PTBBerlinGermany
  4. 4.Fakultät Carl Gustav CarusOncoRay - National Center for Radiation Research in Oncology MedizinischeDresdenGermany

Personalised recommendations