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New Perspectives for MPI: A Toolbox for Tracer Research

  • Nicole Gehrke
  • Andreas Briel
  • Frank Ludwig
  • Hilke Remmer
  • Thilo Wawrzik
  • Stefan Wellert
Part of the Springer Proceedings in Physics book series (SPPHY, volume 140)

Abstract

Since its invention, magnetic particle imaging (MPI) has gained increasing attention in academic as well as industrial research and development. It requires the application of an imaging agent, but the structure-efficacy relations are far from being fully understood and no ideal MPI tracer has been found so far. Here, we present a systematic investigation of the size dependence of the MPI spectra of identically composed, but differently sized iron oxide nanoparticles. We furthermore present a small angle X-ray scattering (SAXS) study as a route to assess the particle core structure. To that goal we used FeraSpinTM R and the FeraSpinTM Series (XS to XXL). We show that FeraSpin R offers an equal whereas FeraSpin L to XXL offer an improved MPI signal as compared to the hitherto “gold-standard” Resovist®. Moreover, the FeraSpin Series constitutes a versatile “toolbox” for MPI tracer research.

Keywords

Particle Core Harmonic Spectrum Iron Oxide Core Spectral Magnitude Hydrodynamic Particle Size 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  • Nicole Gehrke
    • 1
  • Andreas Briel
    • 1
  • Frank Ludwig
    • 2
  • Hilke Remmer
    • 2
  • Thilo Wawrzik
    • 2
  • Stefan Wellert
    • 3
  1. 1.nanoPET Pharma GmbHBerlinGermany
  2. 2.Institut für Elektrische Messtechnik und Grundlagen der ElektrotechnikTU BraunschweigBraunschweigGermany
  3. 3.Stranski LaboratoriumTU BerlinBerlinGermany

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