Nonlinear Modeling of Dose-Response Data

  • Roel Straetemans
Part of the Use R! book series (USE R)


In contrast with Chaps. 2 and 3 in which we discussed the LRT for an order-restricted ANOVA model, Chap. 3 is focused on parametric dose-response modeling of a continuous response variable. The main model of interest will be the four-parameter logistic (4PL) model. Interpretation of the model parameters as well as practical implementation using the R function gnls() is given in Sect.4.2. In Sect. 4.3, we discuss several alternatives for the 4PL model such as the 3PL and 5PL models, the Emax model and growth models such as the Gompertz function and Richards function.


Gompertz Model Emax Model Gompertz Function Gompertz Curve Continuous Response Variable 
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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Ablynx NVZwijnaardeBelgium

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