The Role of Fragmentation on the Formation of Homomeric Protein Complexes

Chapter
Part of the Springer Theses book series (Springer Theses)

Abstract

It is known that many protein complexes are made of smaller identical subunits. The mechanism of assembly of those subunits to form a complete complex is still not well understood. In this work we use a Smoluchowski coagulation equation as a mean-field approximation, and study the efficiency of the process of formation of membrane protein complexes by considering both irreversible aggregation and fragmentation. Our objective is to analyze the possible ways biological organisms adapted to avoid wastage, and achieve a fast formation of the required number of complexes.

Keywords

Open Chain Fragmentation Rate Mechanosensitive Channel Membrane Protein Complex Complete Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Physics, Institute of Complex Systems and Mathematical BiologyUniversity of AberdeenAberdeenUK

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