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Artificial Reproductive Technology (ART)

  • Kurt Benirschke
  • Graham J. Burton
  • Rebecca N. Baergen
Chapter

Abstract

As this chapter is being written, Louise Brown celebrates her 30th birthday and had recently delivered a son, the first “second generation” offspring coming from this new technology. Louise Brown was the first child to be born by ART, that is to say, she was born after in vitro fertilization (Steptoe and Edwards 1978) even though Rock and Menkin were the first investigators to have achieved in vitro fertilization of a human egg (1944). The in vitro fertilization aspect that is part of the ART procedure, performed before the birth of Louise Brown, was undertaken because of obstructed fallopian tubes; numerous earlier attempts had failed. It must also be appreciated that the conception and birth occurred in the midst of considerable social and religious controversy which still prevail. While some of these concerns have somewhat abated, much new controversy has come to light even though millions of conceptions and births have since occurred through the various techniques that are employed by ART physicians. The practice of artificial reproductive technology has since become a recognized specialty in reproductive medicine, specialty journals were created, and the Nobel Prize in Medicine was given to Robert Edwards for this achievement in 2010 (since Steptoe had died in 1988). Interestingly, the practice has yet to be regulated, and only an informal international committee seeks to gather information on the results and problems of ART (Zegers-Hochschild et al. 2006). Since only guidelines, but no regulation exists in the USA, it is worthwhile to read the report on “IFFS Surveillance 07,” edited by Jones et al. (2007). It reports on the laws prevailing in other countries and provides the results from many centers. The Center for Disease Control (CDC) has also issued the clinical results of a large cohort (Wright et al. 2007). The CDC publishes annual reports. In Belgium, the “East Flanders Prospective Twin Study (EFPTS)” was initiated in 1964 and seeks to provide additional data (e.g., Derom et al. 2006). A detailed description of the various types of ART, the success rates of different methods employed, prenatal genetic diagnosis (PGD), and other aspects may be seen at: http://www.sart.org/ and in a review by Allen and Wilson (2006). Moreover, a national workshop was held in 2005 whose publication summarizes the then available data (Reddy et al. 2007). It is emphatic about the necessity for counseling the family, the risk of prematurity, the apparent risk of increased frequency of placenta previa, and it also gives directions for future research. The currently increasingly frequent practice of PGD has been examined by Mastenbroek et al. (2007); its success rate for viable gestations was found to be considerably lower than that for other ART procedures.

Keywords

Placenta Previa Single Embryo Transfer Extravillous Trophoblast Assisted Hatching Monochorionic Twin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Kurt Benirschke
    • 1
  • Graham J. Burton
    • 2
  • Rebecca N. Baergen
    • 3
  1. 1.La JollaUSA
  2. 2.Physiological LaboratoryUniversity of Cambridge Centre for Trophoblast ResearchCambridgeUK
  3. 3.Department of Pathology and Laboratory Medicine New York-Presbyterian HospitalWeill Medical College of Cornell UniversityNew YorkUSA

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