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Trophoblastic Neoplasms

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Pathology of the Human Placenta

Abstract

Among trophoblastic neoplasms, choriocarcinoma is the most well-known. The classification of gestational trophoblastic disease (GTD) has been alluded to in the previous chapter, and Soper et al. (1994) who evaluated 454 tumors according to three classifications found the prognostic aspects to be fairly similar among these otherwise divergent classifications. The clinical staging has so far provided the best prognostication. An excellent and concise review of “chorionic tumors” has summarized recent progress made in understanding and therapy of these lesions (Berkowitz and Goldstein 1996). A checklist for the characterization of trophoblastic malignancies has been published by Lage (1999) and several other noteworthy reviews among many others are those by Silverberg and Kurman (1992), Baergen (1997), Baergen and Rutgers (1997), and others (Seckl et al. 2010; Lurain 2010; Horowitz et al. 2009; Berkowitz and Goldstein 2009).The classification of GTD which includes trophoblastic neoplasms as well as nonneoplastic benign conditions, recently endorsed by the WHO (Tavassoli and Devilee 2003), is the most widely used and is shown in Table 23.1.

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References

  • ACOG (1993) Technical Bulletin No. 178. Management of gestational trophoblastic disease. Int J Gynaecol Obstet 42:308–315

    Google Scholar 

  • Acosta-Sison H (1957) Apparent metastatic chorioepithelioma without demonstrable primary chorionic malignancy in the uterus: report of 3 cases; a new possible explanation of its occurrence. Obstet Gynecol 10:165–168

    PubMed  CAS  Google Scholar 

  • Acosta-Sison H (1958) The relative frequency of various anatomic sites as the point of first metastasis in 32 cases of chorionepithelioma. Am J Obstet Gynecol 75:1149–1152

    PubMed  CAS  Google Scholar 

  • Acosta-Sison H (1966) Choriocarcinoma from July 4, 1963 to June 30, 1965. Philipp J Surg Surg Spec 21:41–42

    PubMed  CAS  Google Scholar 

  • Amiel J-L, Lebovici S (1970) Choriocarcinoma and the HL-A2 antigen (MAC). Rev Eur Etud Clin Biol 15:191–192

    PubMed  CAS  Google Scholar 

  • Arai K, Soma H, Hokano M (1976) Ultrastructure of trophoblastic tumor cells. J Clin Electron Microsc 9:5–6

    Google Scholar 

  • Aranda JM, Martinez I (1969) Incidence of choriocarcinoma in Puerto Rico: a 15-year study. Cancer 23:506–507

    PubMed  CAS  Google Scholar 

  • Arkwright PD, Rademacher TW, Dwek RA, Redman CWG (1993) Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles. J Clin Invest 91:2744–2753

    PubMed  CAS  Google Scholar 

  • Atkin NB (1965) Sex chromosome studies on trophoblast. In: The early conceptus, normal and abnormal. University Court of the University of St. Andrews, Scotland, pp. 130–134

    Google Scholar 

  • Axe SR, Klein VR, Woodruff JD (1985) Choriocarcinoma of the ovary. Obstet Gynecol 66:111–114

    PubMed  CAS  Google Scholar 

  • Baergen RN (1997) Gestational choriocarcinoma. Gen Diagn Pathol 143:127–141

    PubMed  CAS  Google Scholar 

  • Baergen RN, Rutgers JL (1997) Trophoblastic lesions of the placental site. Gen Diagn Pathol 143:143–158

    PubMed  CAS  Google Scholar 

  • Baergen RN, Rutgers J, Young RH (2003) Extrauterine lesions of intermediate trophoblast. Int J Gynecol Pathol 22:362–367

    PubMed  Google Scholar 

  • Baergen RN, Rutgers JL, Young RH, Osann K, Scully RE (2006) Placental site trophoblastic tumor. A study of 55 cases and review of the literature emphasizing factors of prognostic significance. Gynecol Oncol 100:511–520

    PubMed  Google Scholar 

  • Bagshawe KD (1964) Hydatidiform mole and chorioncarcinoma. Br Med J 1:1509–1510

    Google Scholar 

  • Bagshawe KD (1969) Choriocarcinoma. The clinical biology of the trophoblast and its tumors. Williams & Wilkins, Baltimore

    Google Scholar 

  • Bagshawe KD (1988) Pulmonary hypertension in gestational choriocarcinoma: a West London syndrome? Lancet 2:223

    PubMed  CAS  Google Scholar 

  • Bagshawe KD, Noble MIM (1966) Cardio-respiratory aspects of trophoblastic tumors. Q J Med 35:39–54

    PubMed  CAS  Google Scholar 

  • Bagshawe KD, Golding PR, Orr AH (1969) Choriocarcinoma after hydatidiform mole: studies related to effectiveness of follow-up practice after hydatidiform mole. Br Med J 2:733–737

    Google Scholar 

  • Bagshawe KD, Rawlins G, Pike MC, Lawler SD (1971) AB0 blood-groups in trophoblastic neoplasia. Lancet 1:553–557

    PubMed  CAS  Google Scholar 

  • Baltazar JC (1976) Epidemiological features of choriocarcinoma. Bull World Health Organ 54:523–532

    PubMed  CAS  Google Scholar 

  • Bardawil WA, Toy BL (1959) The natural history of choriocarcinoma: problems of immunity and spontaneous regression. Ann N Y Acad Sci 80:197–261

    PubMed  CAS  Google Scholar 

  • Barnes AE, Liwnicz BH, Schellhaus HF, Altshuler G, Aron BS, Lippert WA (1982) Successful treatment of placental choriocarcinoma metastatic to brain followed by primary brain glioblastoma. Gynecol Oncol 13:108–114

    PubMed  CAS  Google Scholar 

  • Beer AE, Billingham RE (1976) The immunobiology of mammalian reproduction. Prentice-Hall, Englewood Cliffs

    Google Scholar 

  • Benjamin F, Rorat E (1978) Primary gestational choriocarcinoma of the ovary. Am J Obstet Gynecol 131:343–345

    PubMed  CAS  Google Scholar 

  • Benson PF, Goldsmith LLG, Rankin GLS (1962) Massive foetal haemorrhage into maternal circulation as a complication of choriocarcinoma. Br Med J 1:841–842

    PubMed  CAS  Google Scholar 

  • Berkowitz RS, Goldstein DP (1996) Chorionic tumors. N Engl J Med 335:1740–1748

    PubMed  CAS  Google Scholar 

  • Berkowitz RS, Goldstein DP (2009) Current management of gestational trophoblastic diseases. Gynecol Oncol 112:654–662

    PubMed  CAS  Google Scholar 

  • Blackburn GK (1976) Massive fetomaternal hemorrhage due to choriocarcinoma of the uterus. J Pediatr 89:680–681

    PubMed  CAS  Google Scholar 

  • Brewer JI, Gerbie AB (1966) Early development of choriocarcinoma. Am J Obstet Gynecol 94:692–705

    PubMed  CAS  Google Scholar 

  • Brewer JI, Mazur MT (1981) Gestational choriocarcinoma: its origin in the placenta during seemingly normal pregnancy. Am J Surg Pathol 5:267–277

    PubMed  CAS  Google Scholar 

  • Brewer JI, Rinehart JJ, Dunbar RW (1961) Choriocarcinoma. Am J Obstet Gynecol 81:574–583

    Google Scholar 

  • Brewer JI, Smith RT, Pratt GB (1963) Choriocarcinoma. Absolute 5 year survival rates of 122 patients treated by hysterectomy. Am J Obstet Gynecol 85:841–843

    PubMed  CAS  Google Scholar 

  • Brewer JI, Gerbie AB, Dolkart RE, Skom JH, Nagle RG, Torok EE (1964) Chemotherapy in trophoblastic diseases. Am J Obstet Gynecol 90:566–578

    PubMed  CAS  Google Scholar 

  • Brewer CA, Adelson MD, Elder RC (1992) Erythrocytosis associated with a placental-site trophoblastic tumor. Obstet Gynecol 79:846–849

    PubMed  CAS  Google Scholar 

  • Buckell EWC, Owen TK (1954) Chorionepithelioma in mother and infant. J Obstet Gynaecol Br Emp 61:329–330

    PubMed  CAS  Google Scholar 

  • Carlson JA, Day TG, Kuhns JG, Howell RS, Masterson BJ (1984) Endoarterial pulmonary metastasis of malignant trophoblast associated with a term intrauterine pregnancy. Gynecol Oncol 17:241–248

    PubMed  Google Scholar 

  • Carr DH (1979) Trophoblast growth in the lungs of mice. Obstet Gynecol 54:461–466

    PubMed  CAS  Google Scholar 

  • Carson SA, Stovall T, Umstot E, Andersen R, Ling F, Buster JE (1989) Rising human chorionic somatomammotropin predicts ectopic pregnancy rupture following methotrexate chemotherapy. Fertil Steril 51:593–597

    PubMed  CAS  Google Scholar 

  • Chandra SA, Gilbert EF, Viseskul C, Strother CM, Haning RV, Javid MJ (1990) Neonatal intracranial choriocarcinoma. Arch Pathol Lab Med 114:1079–1082

    PubMed  CAS  Google Scholar 

  • Cheng H-M, Johnson PM (1988) Specificity of trophoblast-reactive antibodies in human pregnancy. Arch Pathol Lab Med 112:1081

    PubMed  CAS  Google Scholar 

  • Cinader B, Hayley MA, Rider WD, Warwick OH (1961) Immunotherapy of a patient with choriocarcinoma. Can Med Assoc J 84:306–309

    PubMed  CAS  Google Scholar 

  • St. Clair JT, Wheeler DA, Fish SA (1969) Methotrexate in abdominal pregnancy. JAMA 208:529–531

    Google Scholar 

  • Creinin MD, Stewart-Akers AM, DeLoia JA (1998) Methotrexate effects on trophoblast and the corpus luteum in early pregnancy. Am J Obstet Gynecol 179:604–609

    PubMed  CAS  Google Scholar 

  • Crescimanno C, Foidart J-M, Noel A, Polette M, Maquoi E, Birembaut P, Baramova E, Kaufmann P, Castellucci M (1996) Cloning of choriocarcinoma cells shows that invasion correlates with expression and activation of gelatinase A. Exp Cell Res 227:240–251

    PubMed  CAS  Google Scholar 

  • Cunanan RG, Lippes J, Tancinco PA (1980) Choriocarcinoma of the ovary with coexisting normal pregnancy. Obstet Gynecol 55:669–672

    PubMed  Google Scholar 

  • Daamen CBF, Bloem GWD (1961) Chorioepithelioma in mother and child. Ned Tid Geneeskd 105:651–656, J Obstet Gynaecol Br Commonw 68:144–149, 1961

    CAS  Google Scholar 

  • Dallenbach-Hellweg G (1981) Histopathology of the endometrium. Springer, New York

    Google Scholar 

  • Dawood MY (1975) Serum progesterone and serum human chorionic gonadotropin in gestational and nongestational choriocarcinoma. Am J Obstet Gynecol 123:762–765

    PubMed  CAS  Google Scholar 

  • de Kaa CA, van Schijf CPT, de Wilde PCM, de Leeuw H, Gemmink JH, Robben JCM, Vooijs PG (1996) Persistent gestational trophoblastic disease: DNA image cytometry and interphase cytogenetics have limited predictive value. Mod Pathol 9:1007–1014

    PubMed  Google Scholar 

  • Delfs E (1959) Chorionic gonadotrophin determinations in patients with hydatidiform mole and choriocarcinoma. Ann N Y Acad Sci 80:125–142

    PubMed  CAS  Google Scholar 

  • Deligdisch L, Driscoll SG, Goldstein DP (1978) Gestational trophoblastic neoplasms: morphologic correlates of therapeutic response. Am J Obstet Gynecol 130:801–806

    PubMed  CAS  Google Scholar 

  • Doniach I, Crookston JH, Cope TI (1958) Attempted treatment of a patient with choriocarcinoma by immunization with her husband’s cells. J Obstet Gynaecol Br Emp 65:553–556

    PubMed  CAS  Google Scholar 

  • Dougherty CM, Cunningham C, Mickal A (1978) Choriocarcinoma with metastasis in a postmenopausal woman. Am J Obstet Gynecol 132:700–701

    PubMed  CAS  Google Scholar 

  • Driscoll SG (1963) Choriocarcinoma: an “incidental finding” within a term placenta. Obstet Gynecol 21:96–101

    Google Scholar 

  • Driscoll SG (1983) Choriocarcinoma following delivery. Lab Med 48:21A

    Google Scholar 

  • Duleba AJ, Miller D, Taylor G, Effer S (1992) Expectant management of choriocarcinoma limited to placenta. Gynecol Oncol 44:277–280

    PubMed  CAS  Google Scholar 

  • Duncan DA, Mazur MT (1989) Trophoblastic tumors: ultrastructural comparison of choriocarcinoma and placental-site trophoblastic tumor. Hum Pathol 20:370–381

    PubMed  CAS  Google Scholar 

  • Dyke PC, Fink LM (1967) Latent choriocarcinoma. Cancer 20:150–154

    PubMed  CAS  Google Scholar 

  • Eckstein RP, Russell P, Friedlaender M, Tattersall MHN, Bradfield A (1985) Metastasizing placental site trophoblastic tumor: a case study. Hum Pathol 16:632–636

    PubMed  CAS  Google Scholar 

  • Edwards RG, Howe CWS, Johnson MH (eds) (1975) Immunobiology of trophoblast. Cambridge University Press, Cambridge

    Google Scholar 

  • Ehrman RL, Gliserman LE (1964) Choriocarcinoma: growth patterns in hamster tissues. Nature 202:404–406

    Google Scholar 

  • Elston CW (1969) Cellular reaction to choriocarcinoma. J Pathol 97:261–268

    PubMed  CAS  Google Scholar 

  • Emery JL (1952) Chorionepithelioma in a new-born male child with hyperplasia of the interstitial cells of the testis. J Pathol Bacteriol 64:735–739

    PubMed  CAS  Google Scholar 

  • Evans KT, Hendrickse P de V (1965) Pulmonary changes in malignant trophoblastic disease. Br J Radiol 38:161–171

    Google Scholar 

  • Ewing J (1910) Chorioma. Surg Gynecol Obstet 10:366–392

    Google Scholar 

  • Ewing JR (1941) Neoplastic diseases, 4th edn. Saunders, Philadelphia

    Google Scholar 

  • Fahrner RJ, McQueeney AJ, Mosely JM, Petersen RW (1959) Trophoblastic pulmonary thrombosis with cor pulmonale: report of a case due to malignant hydatidiform mole of five years’ duration. JAMA 170:1898–1901

    CAS  Google Scholar 

  • Faul P, Kelehan P, Dervan P (1994) Interphase cytogenetic study of exaggerated placental site trophoblast using a biotin-labelled peroxidase method. Mod Pathol 7:88A (abstract 503)

    Google Scholar 

  • Feldman K (1977) Choriocarcinoma with neonatal anemia. N Engl J Med 296:880

    PubMed  CAS  Google Scholar 

  • Fine G, Smith RW, Pachter MR (1962) Primary extragenital choriocarcinoma in the male subject: case report and review of the literature. Am J Med 32:776–794

    PubMed  CAS  Google Scholar 

  • Finkler NJ, Berkowitz RS, Driscoll SG, Goldstein DP, Bernstein MR (1988) Clinical experience with placental site trophoblastic tumors at the New England Trophoblastic Disease Center. Obstet Gynecol 71:854–857

    PubMed  CAS  Google Scholar 

  • Fischer HE, Lichtiger B, Cox I (1985) Expression of Rh0(D) antigen in choriocarcinoma of the uterus in an Rh0(D)-negative patient: report of a case. Hum Pathol 16:1165–1167

    PubMed  CAS  Google Scholar 

  • Fleetwood M, Dunn DG, Stamatakos MD, McGill LD, Lass TP (2004) Ovarian placental site trophoblastic tumor in a cynomolgus monkey (Macaca fascicularis). Vet Pathol 41(5):582 (abstract 148)

    Google Scholar 

  • Fox H, Laurini RN (1988) Intraplacental choriocarcinoma: report of two cases. J Clin Pathol 41:1085–1088

    PubMed  CAS  Google Scholar 

  • Fukunaga M, Ushigome S (1993a) Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. Hum Pathol 24:1098–1106

    PubMed  CAS  Google Scholar 

  • Fukunaga M, Ushigome S (1993b) Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. Am J Surg Pathol 17:1003–1010

    PubMed  CAS  Google Scholar 

  • Fukunaga M, Ushigome S, Ishikawa E (1995) Choriocarcinoma in situ: a case at an early gestational age. Histopathology 27:473–476

    PubMed  CAS  Google Scholar 

  • Fukunaga M, Nomura K, Ushigome S (1996) Choriocarcinoma in situ at a first trimester. Report of two cases indicating an origin of trophoblast of stem villus. Virchows Arch 429:185–188

    PubMed  CAS  Google Scholar 

  • Gallmeier WM, Bertrams J, Kuwert E, Schmidt CG (1970) Regression des Chorionepithelioms: Zytostatikawirkung und/oder Immunreaktion? Dtsch Med Wochenschr 95:1810–1815

    PubMed  CAS  Google Scholar 

  • Galton M, Goldman PB, Holt SF (1963) Karyotypic and morphologic characterization of a serially transplanted human choriocarcinoma. J Natl Cancer Inst 31:1019–1035

    PubMed  CAS  Google Scholar 

  • Gill TJ, Wegmann G, Nisbet-Brown E (1987) Immunoregulation and fetal survival. Oxford University Press, New York

    Google Scholar 

  • Goldfarb S, Richart RM, Okagaki T (1971) A cytophotometric study of nuclear DNA content of cyto- and syncytiotrophoblast in trophoblastic disease. Cancer 27:83–92

    PubMed  CAS  Google Scholar 

  • Goldstein DP (1972) The chemotherapy of gestational trophoblastic disease. Principles of clinical management. JAMA 220:209–213

    PubMed  CAS  Google Scholar 

  • Goldstein DP, Berkowitz RS (eds) (1982) Trophoblastic neoplasms. Clinical principles of diagnosis and management. Saunders, Philadelphia

    Google Scholar 

  • Greene JB, McCue SA (1978) Choriocarcinoma with cerebral metastases coexistent with a first pregnancy. Am J Obstet Gynecol 131:253–254

    PubMed  CAS  Google Scholar 

  • Grimmer D, Landas S, Kemp JD (1988) IgM antitrophoblast antibodies in a patient with a pregnancy-associated lupuslike disorder, vasculitis, and recurrent intrauterine fetal demise. Arch Pathol Lab Med 112:191–193

    PubMed  CAS  Google Scholar 

  • Guschmann M, Schulz-Bischof K, Vogel M (2003) Incidental chorangiocarcinoma. Case report, immunohistochemistry and theories of possible histogenesis. Pathologe 24:124–127 (in German)

    PubMed  CAS  Google Scholar 

  • Hackett E, Beech M (1961) Immunologic treatment of a case of choriocarcinoma. Br Med J 2:1123–1126

    Google Scholar 

  • Hammond CB, Weed JC, Barnard DE, Tyrey L (1981) Gestational trophoblastic neoplasia. CA Cancer J Clin 31:322–332

    PubMed  CAS  Google Scholar 

  • Heifetz SA, Czaja J (1992) In situ choriocarcinoma arising in partial hydatidiform mole: implications for the risk of persistent trophoblastic disease. Pediatr Pathol 12:601–611

    PubMed  CAS  Google Scholar 

  • Heller EL, Householder JM (1952) Clinicopathologic conference. Am J Clin Pathol 22:883–889

    Google Scholar 

  • Hertig AT, Mansell H (1956) Tumors of the female sex organs. Part I. Hydatidiform mole and choriocarcinoma. In: Atlas of tumor pathology, Sect. IX, Fasc. 33. Armed forces of pathology. Washington, DC

    Google Scholar 

  • Hertz R (1972) Quantitative monitoring of chemotherapy of endocrine tumors by hormone assay. JAMA 222:1163

    PubMed  CAS  Google Scholar 

  • Hertz R (1978) Choriocarcinoma and related gestational trophoblastic tumors in women. Raven, New York

    Google Scholar 

  • Ho H-N, Gill TJ, Klionsky B, Ouyang P-C, Hsieh C-Y, Kunschner A (1989) Differences between white and Chinese populations in human leukocyte antigen sharing and gestational trophoblastic tumors. Am J Obstet Gynecol 161:942–948

    PubMed  CAS  Google Scholar 

  • Homesley HD, Blessing JA, Rettenmaier M, Capizzi RL, Major FJ, Twiggs LB (1988) Weekly intramuscular methotrexate for nonmetastatic gestational trophoblastic disease. Obstet Gynecol 72:413–418

    PubMed  CAS  Google Scholar 

  • Hopkins M, Nunez C, Murphy JR, Wentz WB (1985) Malignant placental site trophoblastic tumor. Obstet Gynecol 66:95S–100S

    PubMed  CAS  Google Scholar 

  • Horn L-C, Bilek K (1997) Histologic classification and staging of gestational trophoblastic disease. Gen Diagn Pathol 143:87–101

    PubMed  CAS  Google Scholar 

  • Horn L-C, Bilek K, Pretzsch G, Baier D (1994) Chorionkarzinom bei tubarer Extrauteringravidität. Geburtsh Frauenheilk 54:375–377

    PubMed  CAS  Google Scholar 

  • Horn L-C, Emmrich P, Bilek K, Bruder E (1996) Der frühe Trophoblast. II. Tumorförmige Störungen der trophoblastären Entwicklung. Zentralbl Gynakol 118:591–597

    PubMed  CAS  Google Scholar 

  • Horn L-C, Göretzlehner U, Dirnhofer S (1997) Placental site trophoblastic tumor (PSTT) initially misdiagnosed as cervical carcinoma. Pathol Res Pract 193:225–230

    PubMed  CAS  Google Scholar 

  • Horowitz NS, Goldstein DP, Berkowitz RS (2009) Management of gestational trophoblastic neoplasia. Sem Oncol 36:181–189

    CAS  Google Scholar 

  • Huber H (1969) Das Chorionepitheliom. Arch Gynakol 207:187–201

    PubMed  CAS  Google Scholar 

  • Huetter PC, Gersell DJ (1993) Placental site nodule: an analysis of 40 cases. Mod Pathol 4:74A (abstract 422)

    Google Scholar 

  • Hui P, Riba A, Pejovic T, Johnson T, Baergen RN, Ward D (2004) Comparative genomic hybridization study of placental site trophoblastic tumour: a report of four cases. Mod Pathol 17:248–251

    PubMed  CAS  Google Scholar 

  • Hustin J, Jauniaux E (1991) Markedly elevated maternal serum alpha-fetoprotein associated with a normal fetus and choriocarcinoma of the placenta. Obstet Gynecol 77:329–330

    PubMed  CAS  Google Scholar 

  • Hutchison JR, Peterson EP, Zimmermann EA (1968) Coexisting metastatic choriocarcinoma and normal pregnancy: therapy during gestation with maternal remission and fetal survival. Obstet Gynecol 31:331–336

    PubMed  CAS  Google Scholar 

  • Iliya FA, Williamson S, Azar HA (1967) Choriocarcinoma in the Near East. Consanguinity as a possible etiologic factor. Cancer 20:144–149

    PubMed  CAS  Google Scholar 

  • Iliya FA, Khuri FP, Khuri SF (1969) Multisystem blood group study in trophoblastic disease. J Med Liban 22:707–711

    PubMed  CAS  Google Scholar 

  • Inferrera C, Pulle C, Rigano A, Palmara D (1967) Aspetti ultrastrutturali e citochimici del coriocarcinoma uterino. Arch Ostet Ginecol 72:707–744

    PubMed  CAS  Google Scholar 

  • Ivaskova E, Jakoubkova J, Zavadil M, Schneid V, Koldovsky P, Ivanyi P (1969) HL-A antigens and choriocarcinoma. Transplant Proc 1:80–81

    PubMed  CAS  Google Scholar 

  • Izhar M, Siebert PD, Oshima RG, DeWolf WC, Fukuda MN (1986) Trophoblastic differentiation of human teratocarcinoma cell line HT-H1. Dev Biol 116:510–518

    PubMed  CAS  Google Scholar 

  • Jacques SM, Qureshi F, Doss BJ, Munkarah A (1998) Intraplacental choriocarcinoma associated with viable pregnancy: pathologic features and implications for the mother and infant. Pediatr Dev Pathol 1:380–387

    PubMed  CAS  Google Scholar 

  • Jarrett DD, Pratt-Thomas HR (1984) Metastatic choriocarcinoma appearing as a unilateral renal mass. Arch Pathol Lab Med 108:356–357

    PubMed  CAS  Google Scholar 

  • Jauniaux E, Zucker M, Meuris S, Verherst A, Wilkin P, Hustin J (1988) Chorangiocarcinoma: an unusual tumour of the placenta; the missing link? Placenta 9:607–613

    PubMed  CAS  Google Scholar 

  • Jones WB (1990) Gestational trophoblastic disease: what have we learned in the past decade? Am J Obstet Gynecol 162:1286–1295

    PubMed  CAS  Google Scholar 

  • Kato M, Tanaka K, Takeuchi S (1982) The nature of trophoblastic disease initiated by transplantation into immunosuppressed animals. Am J Obstet Gynecol 142:497–505

    PubMed  CAS  Google Scholar 

  • Kirk JA (1965) Persistence of abnormal trophoblast. Am J Obstet Gynecol 92:667–669

    PubMed  CAS  Google Scholar 

  • Knoth M, Hesseldahl H, Larsen JF (1969a) Ultrastructure of human choriocarcinoma. Acta Obstet Gynecol 48:100–118

    CAS  Google Scholar 

  • Knoth M, Pattillo RA, Garancis JC, Gey GO, Ruckert ACF, Mattingly RF (1969b) Ultrastructure and hormone synthesis of choriocarcinoma. Am J Pathol 54:479–488

    PubMed  CAS  Google Scholar 

  • Kohorn EI (1983) Theca lutein ovarian cyst may be pathognomonic for trophoblastic neoplasia. Obstet Gynecol 62:80S–81S

    PubMed  CAS  Google Scholar 

  • Kolstad P, Hognestad J (1965) Trophoblastic tumours in Norway. Acta Obstet Gynecol Scand 44:80–88

    PubMed  CAS  Google Scholar 

  • Korhonen J, Alfthan H, Ylöstalo P, Veldhuis J, Stenman U-H (1997) Disappearance of human chorionic gonadotropin and its α- and β-subunits after term pregnancy. Clin Chem 43:2155–2163

    PubMed  CAS  Google Scholar 

  • Kruseman ACN, van Lent M, Blom AH, Lauw GP (1977) Choriocarcinoma in mother and child, identified by immunoenzyme histochemistry. Am J Clin Pathol 67:279–283

    PubMed  CAS  Google Scholar 

  • Kurman RJ, Scully RE, Norris NJ (1976) Trophoblastic pseudotumor of the uterus: an exaggerated form of “syncytial endometritis” simulating a malignant tumor. Cancer 38:1214–1226

    PubMed  CAS  Google Scholar 

  • Kurman RJ, Main CS, Chen H-C (1984) Intermediate trophoblast: a distinctive form of trophoblast with specific morphological, biochemical and functional features. Placenta 5:349–370

    PubMed  CAS  Google Scholar 

  • Kushima K, Noda K, Makita M (1967) Experimental production of chorionic tumor in rabbits. Tohoku J Exp Med 91:209–214

    PubMed  CAS  Google Scholar 

  • Lage JM (1999) Protocols for the examination of specimens from patients with gestational trophoblastic malignancies. A basis for checklists. Arch Pathol Lab Med 123:50–54

    PubMed  CAS  Google Scholar 

  • Lage JM, Roberts DJ (1993) Choriocarcinoma in a term placenta: pathologic diagnosis of tumor in an asymptomatic patient with metastatic disease. Int J Gynecol Pathol 12:80–85

    PubMed  CAS  Google Scholar 

  • Lage JM, Sheikh SS (1997) Genetic aspects of gestational trophoblastic diseases: a general overview with emphasis on new approaches in determining genetic composition. Gen Diagn Pathol 143:109–115

    PubMed  CAS  Google Scholar 

  • Larsen JF, Ehrman RL, Bierring F (1967) Electron microscopy of human choriocarcinoma transplanted into hamster liver. Am J Obstet Gynecol 99:1109–1124

    PubMed  CAS  Google Scholar 

  • Lathrop JC, Wachtel TJ, Meissner GF (1978) Uterine choriocarcinoma fourteen years following bilateral tubal ligation. Obstet Gynecol 51:477–482

    PubMed  CAS  Google Scholar 

  • Lawler SD, Klouda PT, Bagshawe KD (1971) HL-A system in trophoblastic neoplasia. Lancet 2:834–837

    PubMed  CAS  Google Scholar 

  • Leiserowitz GS, Webb MJ (1996) Treatment of placental site trophoblastic tumor with hysterotomy and uterine reconstruction. Obstet Gynecol 88:696–699

    PubMed  CAS  Google Scholar 

  • Lele SM, Crowder SE, Grafe MR (1999) Asymptomatic intraplacental choriocarcinoma diagnosed on routine placental examination. J Perinatol 19:244–247

    PubMed  CAS  Google Scholar 

  • Lewis J, Gore H, Hertig AT, Goss DA (1966) Treatment of trophoblastic disease. Am J Obstet Gynecol 86:710–722

    Google Scholar 

  • Lewis JL, Brown WE, Hertz R, Davis RC, Johnson RH (1968) Heterotransplantation of human choriocarcinoma in monkeys. Cancer Res 28:2032–2038

    PubMed  Google Scholar 

  • Li MC (1972) Chemotherapeutic and immunological aspects of choriocarcinoma. JAMA 222:1163–1164

    PubMed  CAS  Google Scholar 

  • Li MC, Hertz R, Spencer DB (1956) Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma. Proc Soc Exp Biol Med 93:361–366

    PubMed  Google Scholar 

  • Lindsey JR, Wharton LR, Woodruff JD, Baker HJ (1969) Intrauterine choriocarcinoma in a rhesus monkey. Pathol Vet 6:378–384

    PubMed  CAS  Google Scholar 

  • Liu Z, Mira JL, Cruz-Caudillo C (2001) Primary gastric choriocarcinoma. A case report and review of the literature. Arch Pathol Lab Med 125:1601–1604

    PubMed  CAS  Google Scholar 

  • Lurain JR (2011) Gestational trophoblastic disease: II. Classification and management of gestational trophoblastic neoplasia. Am J Obstet Gynecol 204:11–18

    PubMed  Google Scholar 

  • Lurain JR, Sand PK, Brewer JI (1986) Choriocarcinoma associated with ectopic pregnancy. Obstet Gynecol 68:286–287

    PubMed  CAS  Google Scholar 

  • Madarame H, Sakurai H, Konno S (1989) Choriocarcinoma in a DDD mouse: a case report with immunohistochemical and ultrastructural studies. Lab Anim Sci 39:255–258

    PubMed  CAS  Google Scholar 

  • Madden S (1950) Chorionepithelioma of the fallopian tube. J Obstet Gynaecol Br Emp 57:68–70

    PubMed  CAS  Google Scholar 

  • Makino S, Sasaki MS, Fukushima T (1963) Preliminary notes on the chromosomes of human chorionic lesions. Proc Jpn Acad 39:54–58

    Google Scholar 

  • Manivel JC, Niehans G, Wick MR, Dehner LP (1987) Intermediate trophoblast in germ cell neoplasms. Am J Surg Pathol 11:693–701

    PubMed  CAS  Google Scholar 

  • Marchand FJ (1895) Über die sogenannten “decidualen” Geschwülste im Anschluss an normale Geburt, Abort, Blasenmole und Extrauterinschwangerschaft. Monatsschr Geburtsh Gynäkol 1:419–438, 513–560

    Google Scholar 

  • Marin-Padilla M, Benirschke K (1963) Thalidomide induced alterations in the blastocyst and placenta of the armadillo, Dasypus novemcinctus mexicanus, including a choriocarcinoma. Am J Pathol 43:999–1016

    PubMed  CAS  Google Scholar 

  • Marquez Monter H, Velasco AF (1967) Patologia de los tumores trofoblasticos. Bol Asoc Mex Patol 5:11–16

    Google Scholar 

  • Marth C, Lang T, Widschwendter M, Müller-Holzner E, Daxenbichler G (1995) Effects of taxol on choriocarcinoma cells. Am J Obstet Gynecol 173:1835–1842

    PubMed  CAS  Google Scholar 

  • Martin FIR, Carden ABG (1963) Gynaecomastia in chorion-epithelioma – oestrogen levels and probable pathogenesis. Acta Endocrinol (Copenh) 43:203–212

    Google Scholar 

  • Martin BR, Orr JW, Austin JM (1983) Cervical choriocarcinoma associated with an intrauterine contraceptive device: a case report. Am J Obstet Gynecol 147:343–344

    PubMed  Google Scholar 

  • Matalon M, Paz B, Modan M, Modan B (1972) Malignant trophoblastic disorders: epidemiologic aspects and relationship to hydatidiform mole. Am J Obstet Gynecol 112:101–106

    PubMed  CAS  Google Scholar 

  • Mathé G, Dausset J, Hervet E, Amiel JL, Colombani J, Brule G (1964) Immunological studies in patients with placental choriocarcinoma. J Natl Cancer Inst 33:193–208

    PubMed  Google Scholar 

  • Mercer RD, Lammert AC, Anderson R, Hazard JB (1958) Choriocarcinoma in mother and infant. JAMA 166:482–483

    CAS  Google Scholar 

  • Midgley AR, Jaffe RB (1968) Regulation of human gonadotropins: II. Disappearance of human chorionic gonadotropin following delivery. J Clin Endocrinol 28:1712–1718

    CAS  Google Scholar 

  • Miller JM, Surwit EA, Hammond CB (1979) Choriocarcinoma following term pregnancy. Obstet Gynecol 53:207–212

    PubMed  Google Scholar 

  • Mills W (1964) Chorion-carcinoma in the midlands. Clin Radiol 15:260–262

    PubMed  CAS  Google Scholar 

  • Miyamoto M (1971) Experimental induction of choriocarcinoma in rats. Gann 62:55–56

    PubMed  CAS  Google Scholar 

  • Mogensen B, Kissmeyer-Nielsen F (1968) Histocompatibility antigens on the HL-A locus in generalised gestational choriocarcinoma: a family study. Lancet 1:721–724

    PubMed  CAS  Google Scholar 

  • Mogensen B, Kissmeyer-Nielsen F (1971) Current data on HL-A and AB0 typing in gestational choriocarcinoma and invasive mole. Transplant Proc 3:1267–1269

    Google Scholar 

  • Mogensen B, Olsen S (1972) Gestational choriocarcinoma in Denmark 1940–1969: a reappraisal based on modern histologic criteria. Acta Obstet Gynecol Scand 51:63–69

    PubMed  CAS  Google Scholar 

  • Nagelberg SB, Rosen SW (1985) Clinical and laboratory University of Cambridge Centre for Trophoblast Research investigation of a virilized woman with placental-site trophoblastic tumor. Obstet Gynecol 65:527–534

    PubMed  CAS  Google Scholar 

  • Nanke E (1959) Über primär heterotopes (ektopisches) Chorionepitheliom und Chorionepitheliosis. Geburtsh Frauenheilk 19:523–531

    Google Scholar 

  • Nepom GT (1989) The effects of variations in human immune-response genes. N Engl J Med 321:751–752

    PubMed  CAS  Google Scholar 

  • Nickels J, Risberg B, Melander S (1978) Trophoblastic pseudotumour of the uterus. Acta Pathol Microbiol Scand A 86:14–16

    PubMed  CAS  Google Scholar 

  • Nisbet AD, Brehmer RD, Horne CHW, Brooker D, Twiggs LB, Okagaki T (1982) Placental protein 5 in gestational trophoblastic disease: localization and circulating levels. Am J Obstet Gynecol 144:396–401

    PubMed  CAS  Google Scholar 

  • Ober WB (1969) Gestational choriocarcinoma: immunological aspects, diagnosis and treatment. Excerpta Med Int Congr Ser 203:304–315

    Google Scholar 

  • Ober WB, Fass RO (1961) The early history of choriocarcinoma. J Hist Med Allied Sci 16:49–73

    PubMed  CAS  Google Scholar 

  • Ober WB, Maier RC (1981) Gestational choriocarcinoma of the fallopian tube. Diagn Gynecol Obstet 3:213–231

    PubMed  CAS  Google Scholar 

  • Ober WB, Edgcomb JH, Price EB (1971) The pathology of choriocarcinoma. Ann N Y Acad Sci 172:299–426

    PubMed  CAS  Google Scholar 

  • Oettle AG (1961) Malignant neoplasms of the uterus in the white, “coloured,” Indian and Bantu races of the Union of South Africa. Acta Unio Int Contra Cancrum 17:915–933

    PubMed  CAS  Google Scholar 

  • Oldt RJ, Kurman RJ, Shih L-M (2002) Molecular genetic analysis of placental site trophoblastic tumors and epithelioid trophoblastic tumors confirms their trophoblastic origin. Am J Pathol 161:1033–1037

    PubMed  CAS  Google Scholar 

  • Olive DL, Lurain JR, Brewer JI (1984) Choriocarcinoma associated with term gestation. Am J Obstet Gynecol 148:711–716

    PubMed  CAS  Google Scholar 

  • Ollendorff DA, Goldberg JM, Abu-Jawdeh GM, Lurain JR (1990) Markedly elevated maternal serum alpha-fetoprotein associated with a normal fetus and choriocarcinoma of the placenta. Obstet Gynecol 76:494–497

    PubMed  CAS  Google Scholar 

  • Ory SJ, Villanueva AL, Sand PK, Tamura RK (1986) Conservative treatment of ectopic pregnancy with methotrexate. Amer J Obstet Gynecol 154:1299–1306

    CAS  Google Scholar 

  • Parazzini F, La Vecchia C, Mangili G, Caminiti C, Negri E, Cecchetti G, Fasoli M (1988a) Dietary factors and risk of trophoblastic disease. Am J Obstet Gynecol 158:93–100

    PubMed  CAS  Google Scholar 

  • Parazzini F, Mangili G, Belloni C, La Vecchia C, Liati P, Marabini R (1988b) The problem of identification of prognostic factors for persistent trophoblastic disease. Gynecol Oncol 30:57–62

    PubMed  CAS  Google Scholar 

  • Park WW (1957) The occurrence of sex chromatin in chorionepitheliomas and hydatidiform moles. J Pathol Bacteriol 74:197–206

    Google Scholar 

  • Park WW (1971) Choriocarcinoma: a study of its pathology. Davis, Philadelphia

    Google Scholar 

  • Patterson WB (1956) Normal pregnancy after recovery from metastatic choriocarcinoma. Am J Obstet Gynecol 72:183–187

    PubMed  CAS  Google Scholar 

  • Pearl ML, Braga CA (1992) Percutaneous transcatheter embolization for control of life-threatening pelvic hemorrhage from gestational trophoblastic disease. Obstet Gynecol 80:571–574

    PubMed  CAS  Google Scholar 

  • Pierce GB, Midgley AR (1963) The origin and function of human syncytiotrophoblastic giant cells. Am J Pathol 43:153–173

    PubMed  Google Scholar 

  • Pushchak MJ, Farhi DC (1987) Primary choriocarcinoma of the lung. Arch Pathol Lab Med 111:477–479

    PubMed  CAS  Google Scholar 

  • Rahman MS, Al-Suleiman SA, Rahman J, Al-Sibai MH (1982) Advanced abdominal pregnancy – observations in 10 cases. Obstet Gynecol 59:366–372

    PubMed  CAS  Google Scholar 

  • Rauter B (1968) Zum Problem des Chorionepithelioms. Wien Klin Wochenschr 80:634–636

    PubMed  CAS  Google Scholar 

  • Reddy DB, Rao N (1969) Trophoblastic tumors: II. Choriocarcinoma: a review of 50 cases. Indian J Med 23:532–537

    CAS  Google Scholar 

  • Rhoton-Vlasak A, Wagner JM, Rutgers JL, Baergen RN, Young RH, Roche PC, Plummer TB, Gleich GJ (1998) Placental site trophoblastic tumor: human placental lactogen and pregnancy-associated major basic protein as immunohistologic markers. Hum Pathol 29:280–288

    PubMed  CAS  Google Scholar 

  • Riggs JA, Wainer AS, Hahn GA, Farell DM (1964) Extrauterine tubal choriocarcinoma. Am J Obstet Gynecol 88:637–641

    PubMed  CAS  Google Scholar 

  • Roberts JP, Lurain JR (1996) Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. Am J Obstet Gynecol 174:1917–1924

    PubMed  CAS  Google Scholar 

  • Robinson E, Shulman J, Ben-Hur N, Zuckerman H, Neuman Z (1963) Immunological studies and behaviour of husband and foreign homografts in patients with chorionepithelioma. Lancet 1:300–302

    PubMed  CAS  Google Scholar 

  • Rolon PA, Lopez BH (1979) Malignant trophoblastic disease in Paraguay. J Reprod Med 23:94–96

    PubMed  CAS  Google Scholar 

  • Rosenheim NB, Wijnen H, Woodruff JD (1980) Clinical importance of the diagnosis of trophoblastic pseudotumors. Am J Obstet Gynecol 136:635–638

    Google Scholar 

  • Rotmensch S, Cole LA (2000) False diagnosis and needless therapy of presumed malignant disease in women with false-positive human chorionic gonadotropin concentrations. Lancet 355:712–715

    PubMed  CAS  Google Scholar 

  • Rudolph RH, Thomas ED (1971) HL-A antigens and choriocarcinoma. Lancet 2:408–409

    PubMed  CAS  Google Scholar 

  • Rutgers JL, Baergen RN, Young RH, Scully RE (1995) Placental site trophoblastic tumor: clinicopathologic study of 64 cases. Mod Pathol 8:96A

    Google Scholar 

  • Santamaria M, Benirschke K, Carpenter PM, Baldwin VJ, Pritchard JA (1987) Transplacental hemorrhage associated with placental neoplasms. Pediatr Pathol 7:601–615

    PubMed  CAS  Google Scholar 

  • Schopper W, Pliess G (1949) Über Chorionepitheliosis: ein Beitrag zur Genese. Diagnostik und Bedeutung ektopischer chorionepithelialer Wucherungen. Virchows Arch 317:347–384

    Google Scholar 

  • Scott JS (1962) Choriocarcinoma. Am J Obstet Gynecol 83:185–193

    PubMed  CAS  Google Scholar 

  • Scott JS (1968) Histocompatibility antigens in choriocarcinoma. Lancet 1:865–866

    PubMed  CAS  Google Scholar 

  • Scully RE, Young RH (1981) Trophoblastic pseudotumor: a reappraisal. Am J Surg Pathol 5:75–76

    PubMed  CAS  Google Scholar 

  • Searle F, Leake BA, Bagshawe KD, Dent J (1978) Serum-SP1-pregnancy-specific-β-glycoprotein in choriocarcinoma and other neoplastic disease. Lancet 1:579–581

    PubMed  CAS  Google Scholar 

  • Seckl MJ, Newlands ES (1997) Treatment of gestational trophoblastic disease. Gen Diagn Pathol 143:159–171

    PubMed  CAS  Google Scholar 

  • Seckl MJ, Rustin GJS, Newlands ES, Gwyther SJ, Bomanji J (1991) Pulmonary embolism, pulmonary hypertension, and choriocarcinoma. Lancet 338:1313–1315

    PubMed  CAS  Google Scholar 

  • Seckl MJ, Fisher RA, Salerno G, Rees H, Paradinas FJ, Foskett M, Newlands ES (2000) Choriocarcinoma and partial hydatidiform moles. Lancet 356:11443–11444

    Google Scholar 

  • Seckl MJ, Sebire NJ, Berkowitz RS (2010) Gestational trophoblastic disease. Lancet 376:717–729

    PubMed  Google Scholar 

  • Sheppard DM, Fisher RA, Lawler SD (1985) Karyotypic analysis and chromosome polymorphisms in four choriocarcinoma cell lines. Cancer Genet Cytogenet 16:251–258

    PubMed  CAS  Google Scholar 

  • Shih IM, Kurman RJ (1998a) Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. Hum Pathol 29:27–33

    PubMed  CAS  Google Scholar 

  • Shih I-M, Kurman RJ (1998b) Epithelioid trophoblastic tumor. A neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. Am J Surg Pathol 22:1393–1403

    PubMed  CAS  Google Scholar 

  • Shih IM, Kurman RJ (2001) The pathology of intermediate trophoblastic tumors and tumor-like lesions. Int J Gynecol Pathol 20:31–47

    PubMed  CAS  Google Scholar 

  • Shih IM, Kurman RJ (2004) p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. Amer J Surg Pathol 28:1177–1183

    Google Scholar 

  • Shih IM, Seidman JD, Kurman RJ (1999) Placental site nodule and characterization of distinctive types of intermediate trophoblast. Hum Pathol 30:687–694

    PubMed  CAS  Google Scholar 

  • Shih I-M, Singer G, Kurman RJ (2002) Establishment of intermediate trophoblastic cell lines from PSTT and complete hydatidiform mole. Mod Pathol 15:210A (abstract 880)

    Google Scholar 

  • Shintani S, Glass LE, Page EW (1966) Studies of induced malignant tumors of placental and uterine origin in the rat. I. Survival of placental tissue following fetectomy. II. Induced tumors and their pathogenesis with special reference to choriocarcinoma. III. Identification of experimentally induced choriocarcinoma by detection of placental hormone. Am J Obstet Gynecol 95:542–549, 550–558; 559–563

    PubMed  CAS  Google Scholar 

  • Silverberg SG, Kurman RJ (1992) Tumors of the uterine corpus and gestational trophoblastic disease. Atlas of tumor pathology, Third Series, Fascicle 3. AFIP, Washington, DC

    Google Scholar 

  • Sohn N, Chen S, Kalra J (1996) Nonmetastatic trophoblastic neoplasia of the cervix following termination of a cervical pregnancy. Obstet Gynecol 88:733

    PubMed  CAS  Google Scholar 

  • Soma H, Kiyokawa T, Akaeda T, Miyashita T, Matayoshi K (1973) The chromosomes of a human choriocarcinoma cell line in vitro with special reference to the presence of Y chromosome. Acta Obstet Gynaecol Jpn 20:239–242

    Google Scholar 

  • Soma H, Takayama M, Tokoro K, Kikuchi T, Kikuchi K, Saegusa H (1980) Radioimmunoassay of hCG as an early diagnosis of cerebral metastases in choriocarcinoma patients. Acta Obstet Gynecol Scand 59:445–448

    PubMed  CAS  Google Scholar 

  • Soper JT, Mutch DG, Chin N, Clarke-Pearson DL, Hammond CB (1988) Renal metastases of gestational trophoblastic disease: a report of eight cases. Obstet Gynecol 72:796–798

    PubMed  CAS  Google Scholar 

  • Soper JT, Evans AC, Conaway MR, Clarke-Pearson DL, Berchuck A, Hammond CB (1994) Evaluation of prognostic factors and staging in gestational trophoblastic tumor. Obstet Gynecol 84:969–973

    PubMed  CAS  Google Scholar 

  • Spiegel JA (1964) Endoarterial choriocarcinoma of the lung: report of a case and review of the literature. Obstet Gynecol 24:740–748

    PubMed  CAS  Google Scholar 

  • Srivannaboon S (1971) Antigenicity of human choriocarcinoma. Int J Fertil 16:36–41

    PubMed  CAS  Google Scholar 

  • Stein-Werblowsky T (1960) Induction of a chorion-epitheliomatous tumour in the rat. Nature 186:980

    PubMed  CAS  Google Scholar 

  • Sullivan LG (1989) Primary choriocarcinoma of the lung in a man. Arch Pathol Lab Med 113:82–83

    PubMed  CAS  Google Scholar 

  • Surwit EA, Alberts DS, Christian CD, Graham VE (1984) Poor-prognosis gestational trophoblastic disease: an update. Obstet Gynecol 64:21–26

    PubMed  CAS  Google Scholar 

  • Suzuki T, Goto S, Nawa A, Kurauchi O, Saito M, Tomoda Y (1993) Identification of the pregnancy responsible for gestational trophoblastic disease by DNA analysis. Obstet Gynecol 82:629–634

    PubMed  CAS  Google Scholar 

  • Szulman AE, Buchsbaum HJ (eds) (1987) Gestational trophoblastic disease. Springer, New York

    Google Scholar 

  • Tanimura A, Natsuyama H, Kawano M, Tanimura Y, Tanaka T, Kitazono M (1985) Primary choriocarcinoma of the lung. Hum Pathol 16:1281–1284

    PubMed  CAS  Google Scholar 

  • Tavassoli FA, Devilee P (2003) World health organization classification of tumours: pathology and genetics. Tumours of the breast and female genital organs. IARC, Lyon

    Google Scholar 

  • Teacher JH (1903) On chorionepithelioma and the occurrence of chorionepitheliomatous and hydatidiform mole-like structures in teratomata: a pathological and clinical study. J Obstet Gynaecol Br Emp 4:1–64, 145–199

    Google Scholar 

  • Thiersch JB (1952) Therapeutic abortions with a folic acid antagonist, 4-aminopteroylglutamic acid (4-amino P.G.A.) administered by the oral route. Am J Obstet Gynecol 63:1298–1304

    PubMed  CAS  Google Scholar 

  • Tomoda Y, Fuma M, Saiki N, Ishizuka N, Akaza T (1976) Immunologic studies in patients with trophoblastic neoplasia. Am J Obstet Gynecol 126:661–667

    PubMed  CAS  Google Scholar 

  • Tomoda Y, Kaseki S, Goto S, Nishi H, Hara T, Naruki M (1981) Rh-D factor in trophoblastic tumors: a possible cause of the high incidence in Asia. Am J Obstet Gynecol 139:742–743

    PubMed  CAS  Google Scholar 

  • Tow SH (1965) Choriocarcinoma: a review of current concepts based on the Singapore experience. Singapore Med J 6:117–126

    Google Scholar 

  • Trask C, Lage JM, Roberts DJ (1994) A second case of “chorangiocarcinoma” presenting in a term asymptomatic twin pregnancy: choriocarcinoma in situ with associated villous vascular proliferation. Int J Gynecol Pathol 13:87–91

    PubMed  CAS  Google Scholar 

  • Tsang WYW, Chum NPY, Tang SK, Tse CCH, Chan JKC (1993) Mallory’s bodies in placental site nodule. Arch Pathol Lab Med 117:547–550

    PubMed  CAS  Google Scholar 

  • Turner HB, Douglas WM, Gladding TC (1964) Choriocarcinoma of the ovary. Obstet Gynecol 24:918–920

    PubMed  CAS  Google Scholar 

  • van Bogaert L-J, Staquet J-P (1977) Chorionepitheliosis: a rare benign trophoblastic disease. Acta Obstet Gynecol Scand 56:69–73

    PubMed  Google Scholar 

  • Van Thiel DH, Ross GT, Lipsett MB (1970) Pregnancies after chemotherapy of trophoblastic neoplasms. Science 169:1326–1327

    PubMed  Google Scholar 

  • Vaughn TC, Surwit EA, Hammond CB (1980) Late recurrences of gestational trophoblastic neoplasia. Am J Obstet Gynecol 138:73–76

    PubMed  CAS  Google Scholar 

  • Veinot JP, Ford SE, Price RG (1992) Subacute cor pulmonale due to tumor embolization. Arch Pathol Lab Med 116:131–134

    PubMed  CAS  Google Scholar 

  • Wake N, Tanaka K, Chapman V, Matsui S, Sandberg AA (1981) Chromosomes and cellular origin of choriocarcinoma. Cancer Res 41:3137–3143

    PubMed  CAS  Google Scholar 

  • Walden PAM, Bagshawe KD (1976) Reproductive performance of women successfully treated for gestational trophoblastic tumors. Am J Obstet Gynecol 125:1108–1114

    PubMed  CAS  Google Scholar 

  • Weed JC, Hammond CB (1980) Cerebral metastatic choriocarcinoma: intensive therapy and prognosis. Obstet Gynecol 55:89–94

    PubMed  Google Scholar 

  • Wegmann TG, Gill TJ (1983) Immunology of reproduction. Oxford University Press, New York

    Google Scholar 

  • Wehmann RE, Ayala AR, Birken S, Canfield RE, Nisula BC (1981) Improved monitoring of gestational trophoblastic neoplasia using a highly sensitive assay for urinary human chorionic gonadotropin. Am J Obstet Gynecol 140:753–757

    PubMed  CAS  Google Scholar 

  • Wei PY, Cuyang PC (1963) Trophoblastic disease in Taiwan: a review of 157 cases in a 10 year period. Am J Obstet Gynecol 85:844–849

    PubMed  CAS  Google Scholar 

  • Wells M, Bulmer JN (1988) The human placental bed: histology, immunohistochemistry and pathology. Histopathology 13:483–498

    PubMed  CAS  Google Scholar 

  • Wenger ME, Dines DE, Ahmann DL, Good CA (1968) Primary mediastinal choriocarcinoma. Mayo Clin Proc 43:570–575

    PubMed  CAS  Google Scholar 

  • Witzleben CL, Bruninga G (1968) Infantile choriocarcinoma: a characteristic syndrome. J Pediatr 73:374–378

    PubMed  CAS  Google Scholar 

  • Wolf HK, Michalopoulos GK (1992) Proliferating cell nuclear antigen in human placenta and trophoblastic disease. Pediatr Pathol 12:147–154

    PubMed  CAS  Google Scholar 

  • Wynn RM, Davies J (1964) Ultrastructure of transplanted choriocarcinoma and its endocrine implications. Am J Obstet Gynecol 88:618–633

    PubMed  CAS  Google Scholar 

  • Yamashita K, Nakamura T, Shimizu T (1984) Absence of major histocompatibility complex antigens in choriocarcinoma. Am J Obstet Gynecol 150:896–897

    PubMed  CAS  Google Scholar 

  • Yazaki K, Yazaki C, Wakabayashi K, Igarashi M (1980) Isoelectric heterogeneity of human chorionic gonadotropin: presence of choriocarcinoma specific components. Am J Obstet Gynecol 138:189–194

    PubMed  CAS  Google Scholar 

  • Yen S, MacMahon B (1968) Epidemiologic features of trophoblastic disease. Am J Obstet Gynecol 101:126–132

    PubMed  CAS  Google Scholar 

  • Young RH, Kurman RJ, Scully RE (1990) Placental site nodules and plaques. A clinicopathologic analysis of 20 cases. Am J Surg Pathol 14:1001–1009

    PubMed  CAS  Google Scholar 

  • Yuen BH, Cannon W, Benedet JL, Boyes DA (1977) Plasma β-subunit human chorionic gonadotropin assay in molar pregnancy and choriocarcinoma. Am J Obstet Gynecol 127:711–712

    PubMed  CAS  Google Scholar 

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  1. Prestwick Drive, La Jolla, CA, USA

    Kurt Benirschke M.D.

  2. Physiological Laboratory, University of Cambridge Centre for Trophoblast Research, Cambridge, UK

    Graham J. Burton M.D., D.Sc.

  3. Department of Pathology and Laboratory Medicine New York-Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY, USA

    Rebecca N. Baergen M.D.

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Benirschke, K., Burton, G.J., Baergen, R.N. (2012). Trophoblastic Neoplasms. In: Pathology of the Human Placenta. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23941-0_23

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