Mapping the Effects of Aβ1 − 42 Levels on the Longitudinal Changes in Healthy Aging: Hierarchical Modeling Based on Stationary Velocity Fields

  • Marco Lorenzi
  • Nicholas Ayache
  • Giovanni B Frisoni
  • Xavier Pennec
  • ADNI
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6892)


Mapping the effects of different clinical conditions on the evolution of the brain structural changes is of central interest in the field of neuroimaging. A reliable description of the cross-sectional longitudinal changes requires the consistent integration of intra and inter-subject variability in order to detect the subtle modifications in populations. In computational anatomy, the changes in the brain are often measured by deformation fields obtained through non rigid registration, and the stationary velocity field (SVF) parametrization provides a computationally efficient registration scheme. The aim of this study is to extend this framework into an efficient and robust multilevel one for accurately modeling the longitudinal changes in populations. This setting is used to investigate the subtle effects of the positivity of the CSF Aβ 1 − 42 levels on brain atrophy in healthy aging. Thanks to the higher sensitivity of our framework, we obtain statistically significant results that highlight the relationship between brain damage and positivity to the marker of Alzheimer’s disease and suggest the presence of a presymptomatic pattern of the disease progression.


Brain Atrophy Healthy Aging Longitudinal Change Parallel Transport Rigid Registration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Marco Lorenzi
    • 1
    • 2
  • Nicholas Ayache
    • 1
  • Giovanni B Frisoni
    • 2
  • Xavier Pennec
    • 1
  • ADNI
  1. 1.Project Team Asclepios, INRIA Sophia AntipolisFrance
  2. 2.LENITEM, IRCCS San Giovanni di Dio, FatebenefratelliBresciaItaly

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