Integrated Parcellation and Normalization Using DTI Fasciculography

  • Hon Pong Ho
  • Fei Wang
  • Xenophon Papademetris
  • Hilary P. Blumberg
  • Lawrence H. Staib
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6892)


Existing methods for fiber tracking, interactive bundling and editing from Diffusion Magnetic Resonance Images (DMRI) reconstruct white matter fascicles using groups of virtual pathways. Classical numerical fibers suffer from image noise and cumulative tracking errors. 3D visualization of bundles of fibers reveals structural connectivity of the brain; however, extensive human intervention, tracking variations and errors in fiber sampling make quantitative fascicle comparison difficult. To simplify the process and offer standardized white matter samples for analysis, we propose a new integrated fascicle parcellation and normalization method that combines a generic parametrized volumetric tract model with orientation information from diffusion images. The new technique offers a tract-derived spatial parameter for each voxel within the model. Cross-subject statistics of tract data can be compared easily based on these parameters. Our implementation demonstrated interactive speed and is available to the public in a packaged application.


Seed Point Tracking Result Diffusion Magnetic Resonance Image Tract Axis Tract Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Hon Pong Ho
    • 1
  • Fei Wang
    • 4
  • Xenophon Papademetris
    • 1
    • 3
  • Hilary P. Blumberg
    • 3
    • 4
  • Lawrence H. Staib
    • 1
    • 2
    • 3
  1. 1.Departments of Biomedical EngineeringYale UniversityNew HavenUSA
  2. 2.Departments of Electrical EngineeringYale UniversityNew HavenUSA
  3. 3.Departments of Diagnostic RadiologyYale UniversityNew HavenUSA
  4. 4.Departments of PsychiatryYale UniversityNew HavenUSA

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