Midbrain Segmentation in Transcranial 3D Ultrasound for Parkinson Diagnosis

  • Seyed-Ahmad Ahmadi
  • Maximilian Baust
  • Athanasios Karamalis
  • Annika Plate
  • Kai Boetzel
  • Tassilo Klein
  • Nassir Navab
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6893)


Ultrasound examination of the human brain through the temporal bone window, also called transcranial ultrasound (TC-US), is a completely non-invasive and cost-efficient technique, which has established itself for differential diagnosis of Parkinson’s Disease (PD) in the past decade. The method requires spatial analysis of ultrasound hyper-echogenicities produced by pathological changes within the Substantia Nigra (SN), which belongs to the basal ganglia within the midbrain. Related work on computer aided PD diagnosis shows the urgent need for an accurate and robust segmentation of the midbrain from 3D TC-US, which is an extremely difficult task due to poor image quality of TC-US. In contrast to 2D segmentations within earlier approaches, we develop the first method for semi-automatic midbrain segmentation from 3D TC-US and demonstrate its potential benefit on a database of 11 diagnosed Parkinson patients and 11 healthy controls.


Substantia Nigra Shape Model Statistical Shape Model Shape Vector Ground Truth Segmentation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Seyed-Ahmad Ahmadi
    • 1
  • Maximilian Baust
    • 1
  • Athanasios Karamalis
    • 1
  • Annika Plate
    • 2
  • Kai Boetzel
    • 2
  • Tassilo Klein
    • 1
  • Nassir Navab
    • 1
  1. 1.Computer Aided Medical ProceduresTechnische Universität MünchenGermany
  2. 2.Department of NeurologyLudwig-Maximilians-University of MunichGermany

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