Parathyroid Carcinoma

  • Janice L. Pasieka
  • Moosa Khalil


Parathyroid carcinoma is a rare malignant neoplasm derived from the parenchymal cells of the parathyroid gland. The first description of this malignant tumor was by de Quevain in 1904. Making up only a small percentage of parathyroid carcinomas seen today, the first tumor described was actually a nonfunctioning tumor. It was not until 1933 when Sainton and Millot first described a case of metastatic parathyroid carcinoma causing manifestations of Recklinghausen disease, commonly known today as hyperparathyroidism (HPTH). Parathyroid carcinoma is an uncommon cause of PTH-dependant hypercalcemia accounting for only 1–3% of cases of primary HPTH. Since de Quevain’s initial article, there have been over 800 cases reported in the literature. From these reports, it is apparent that parathyroid cancer characteristically presents with more profound manifestations of HPTH than parathyroid adenomas and benign hyperplasia.


Parathyroid Gland Recurrent Laryngeal Nerve Multiple Endocrine Neoplasia Type Parathyroid Adenoma Bloc Resection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Surgery, Faculty of MedicineUniversity of CalgaryCalgaryCanada
  2. 2.Department of PathologyUniversity of CalgaryCalgaryCanada
  3. 3.Calgary Laboratory ServicesCalgaryCanada

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