Skip to main content

Surgical Approaches to Mediastinal Parathyroid Glands

  • Chapter
  • First Online:
Surgery of the Thyroid and Parathyroid Glands

Abstract

The mediastinal parathyroid gland typically results from the failure of the parathyroid glands to cease at their normal position adjacent to the thyroid gland during their descent from the third and fourth pharyngeal pouches. An understanding of the possible anatomic locations of the aberrant parathyroid glands as well as the anatomy of the mediastinum itself is important to developing an effective diagnostic and management strategy. Combining this knowledge with one or several of the preoperative localization techniques that exist can contribute to the successful localization and subsequent resection of an anomalous mediastinal parthyroid gland. The hyperfunctioning ectopic, mediastinal parathyroid gland can usually be addressed operatively through a neck approach. Occasionally though, a thoracic approach is needed and selecting the optimal thoracic approach is dependent upon accurate preoperative localization of the aberrant gland as well as the expertise of the surgeon. The objectives of this chapter are to provide an overview of the ectopic mediastinal parathyroid gland, discuss the associated localization techniques, and describe the open and minimally invasive approaches that can be used when performing a mediastinal parathyroidectomy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Wang C, Gaz RD, Moncure AC (1986) Mediastinal parathyroid exploration: a clinical and pathologic study of 47 cases. World J Surg 10(4):687–695

    Article  PubMed  CAS  Google Scholar 

  2. Nathaniels EK, Nathaniels AM, Wang CA (1970) Mediastinal parathyroid tumors: a clinical and pathological study of 84 cases. Ann Surg 171(2):165–170

    Article  PubMed  CAS  Google Scholar 

  3. Brennan MF, Marx SJ, Doppman J et al (1981) Results of reoperation for persistent and recurrent hyperparathyroidism. Ann Surg 194(6):671–676

    Article  PubMed  CAS  Google Scholar 

  4. Wang CA (1977) Parathyroid re-exploration. A clinical and pathological study of 112 cases. Ann Surg 186(2):140–145

    Article  PubMed  CAS  Google Scholar 

  5. Edis AJ, Sheedy PF, Beahrs OH, van Heerden JA (1978) Results of reoperation for hyperparathyroidism, with evaluation of ­preoperative localization studies. Surgery 84(3):384–393

    PubMed  CAS  Google Scholar 

  6. Scholz DA, Purnell DC, Woolner LB, Clagett OT (1973) Mediastinal hyperfunctioning parathyroid tumors: review of 14 cases. Ann Surg 178(2):173–178

    Article  PubMed  CAS  Google Scholar 

  7. Russell CF, Edis AJ, Scholz DA, Sheedy PF, van Heerden JA (1981) Mediastinal parathyroid tumors: experience with 38 tumors requiring mediastinotomy for removal. Ann Surg 193(6):805–809

    Article  PubMed  CAS  Google Scholar 

  8. Callender GG, Grubbs EG, Vu T et al (2009) The fallen one: the inferior parathyroid gland that descends into the mediastinum. J Am Coll Surg 208(5):887–893, discussion 93–95

    Article  PubMed  Google Scholar 

  9. O’Herrin JK, Weigel T, Wilson M, Chen H (2002) Radioguided parathyroidectomy via VATS combined with intraoperative parathyroid hormone testing: the surgical approach of choice for patients with mediastinal parathyroid adenomas? J Bone Miner Res 17(8):1368–1371

    Article  PubMed  Google Scholar 

  10. Russell CF, Grant CS, van Heerden JA (1982) Hyperfunctioning supernumerary parathyroid glands. An occasional cause of hyperparathyroidism. Mayo Clin Proc 57(2):121–124

    PubMed  CAS  Google Scholar 

  11. Phitayakorn R, McHenry CR (2006) Incidence and location of ectopic abnormal parathyroid glands. Am J Surg 191(3):418–423

    Article  PubMed  Google Scholar 

  12. Conn JM, Goncalves MA, Mansour KA, McGarity WC (1991) The mediastinal parathyroid. Am Surg 57(1):62–66

    PubMed  CAS  Google Scholar 

  13. Roslyn JJ, Gordon HE, Mulder DG (1983) Mediastinal parathyroid adenomas. A cause of persistent hyperparathyroidism. Am Surg 49(10):523–527

    PubMed  CAS  Google Scholar 

  14. Akerstrom G, Malmaeus J, Bergstrom R (1984) Surgical anatomy of human parathyroid glands. Surgery 95(1):14–21

    PubMed  CAS  Google Scholar 

  15. Prinz RA, Lonchyna V, Carnaille B, Wurtz A, Proye C (1994) Thoracoscopic excision of enlarged mediastinal parathyroid glands. Surgery 116(6):999–1004, discussion 1004–1005

    PubMed  CAS  Google Scholar 

  16. Arnault V, Beaulieu A, Lifante JC et al (2010) Multicenter study of 19 aortopulmonary window parathyroid tumors: the ­challenge of embryologic origin. World J Surg 34(9):2211–2216

    Article  PubMed  Google Scholar 

  17. Wang C, Mahaffey JE, Axelrod L, Perlman JA (1979) Hyperfunctioning supernumerary parathyroid glands. Surg Gynecol Obstet 148(5):711–714

    PubMed  CAS  Google Scholar 

  18. Mendoza V, Ramirez C, Espinoza AE et al (2010) Characteristics of ectopic parathyroid glands in 145 cases of primary hyperparathyroidism. Endocr Pract 16:977–981

    Article  PubMed  Google Scholar 

  19. Alesina PF, Moka D, Mahlstedt J, Walz MK (2008) Thoracoscopic removal of mediastinal hyperfunctioning parathyroid glands: personal experience and review of the literature. World J Surg 32(2):224–231

    Article  PubMed  CAS  Google Scholar 

  20. Cupisti K, Dotzenrath C, Simon D, Roher HD, Goretzki PE (2002) Therapy of suspected intrathoracic parathyroid adenomas. Experiences using open transthoracic approach and video-assisted thoracoscopic surgery. Langenbecks Arch Surg 386(7):488–493

    Article  PubMed  Google Scholar 

  21. Gaz RD, Doubler PB, Wang CA (1987) The management of 50 unusual hyperfunctioning parathyroid glands. Surgery 102(6):949–957

    PubMed  CAS  Google Scholar 

  22. Gold JS, Donovan PI, Udelsman R (2006) Partial median sternotomy: an attractive approach to mediastinal parathyroid disease. World J Surg 30(7):1234–1239

    Article  PubMed  Google Scholar 

  23. Norton JA, Schneider PD, Brennan MF (1985) Median sternotomy in reoperations for primary hyperparathyroidism. World J Surg 9(5):807–813

    Article  PubMed  CAS  Google Scholar 

  24. Rothmund M, Diethelm L, Brunner H, Kummerle F (1976) Diagnosis and surgical treatment of mediastinal parathyroid tumors. Ann Surg 183(2):139–145

    Article  PubMed  CAS  Google Scholar 

  25. Taguchi M, Endo S, Hasegawa T, Sato Y, Sohara Y (2006) Thoracoscopic findings of a small posterior mediastinal parathyroid adenoma. Asian Cardiovasc Thorac Ann 14(5):e86–e87

    PubMed  Google Scholar 

  26. Curley IR, Wheeler MH, Thompson NW, Grant CS (1988) The challenge of the middle mediastinal parathyroid. World J Surg 12(6):818–824

    Article  PubMed  CAS  Google Scholar 

  27. Prescott JD, Udelsman R (2009) Remedial operation for primary hyperparathyroidism. World J Surg 33(11):2324–2334

    Article  PubMed  Google Scholar 

  28. Clark OH (1988) Mediastinal parathyroid tumors. Arch Surg 123(9):1096–1100

    Article  PubMed  CAS  Google Scholar 

  29. Medrano C, Hazelrigg SR, Landreneau RJ, Boley TM, Shawgo T, Grasch A (2000) Thoracoscopic resection of ectopic parathyroid glands. Ann Thorac Surg 69(1):221–223

    Article  PubMed  CAS  Google Scholar 

  30. Nilubol N, Beyer T, Prinz RA, Solorzano CC (2007) Mediastinal hyperfunctioning parathyroids: incidence, evolving treatment, and outcome. Am J Surg 194(1):53–56

    Article  PubMed  Google Scholar 

  31. Quiros RM, Warren W, Prinz RA (2004) Excision of a mediastinal parathyroid gland with use of video-assisted thoracoscopy, intraoperative 99mTc-sestamibi scanning, and intraoperative monitoring of intact parathyroid hormone. Endocr Pract 10(1):45–48

    PubMed  Google Scholar 

  32. Akin H, Gunluoglu Z, Kara V, Melek H, Dincer I (2008) Mediastinal ectopic parathyroid adenoma: report of two cases successfully treated by VATS approach. Thorac Cardiovasc Surg 56(1):60–62

    Article  PubMed  CAS  Google Scholar 

  33. Onoda N, Ishikawa T, Yamada N et al (2002) Radioisotope-navigated video-assisted thoracoscopic operation for ectopic mediastinal parathyroid. Surgery 132(1):17–19

    Article  PubMed  Google Scholar 

  34. Burger AE, Skene AI, Lagattolla NR (2008) Thoracoscopic excision of mediastinal parathyroid adenomas: a report of two cases. Ann R Coll Surg Engl 90(2):W1–W5

    Article  PubMed  CAS  Google Scholar 

  35. Chen H, Mack E, Starling JR (2005) A comprehensive evaluation of perioperative adjuncts during minimally invasive parathyroidectomy: which is most reliable? Ann Surg 242(3):375–380, discussion 80–83

    PubMed  Google Scholar 

  36. Ott MC, Malthaner RA, Reid R (2001) Intraoperative radioguided thoracoscopic removal of ectopic parathyroid adenoma. Ann Thorac Surg 72(5):1758–1760

    Article  PubMed  CAS  Google Scholar 

  37. Liu RC, Hill ME, Ryan JA Jr (2005) One-gland exploration for mediastinal parathyroid adenomas: cervical and thoracoscopic approaches. Am J Surg 189(5):601–604, discussion 5

    Article  PubMed  Google Scholar 

  38. Sukumar MS, Komanapalli CB, Cohen JI (2006) Minimally invasive management of the mediastinal parathyroid adenoma. Laryngoscope 116(3):482–487

    Article  PubMed  Google Scholar 

  39. Chae AW, Perricone A, Brumund KT, Bouvet M (2008) Outpatient video-assisted thoracoscopic surgery (VATS) for ectopic mediastinal parathyroid adenoma: a case report and review of the literature. J Laparoendosc Adv Surg Tech A 18(3):383–390

    Article  PubMed  Google Scholar 

  40. Timmerman GL, Allard B, Lovrien F, Hickey D (2008) Hyperparathyroidism: robotic-assisted thoracoscopic resection of a supernumerary anterior mediastinal parathyroid tumor. J Laparoendosc Adv Surg Tech A 18(1):76–79

    Article  PubMed  Google Scholar 

  41. Chan AP, Wan IY, Wong RH, Hsin MK, Underwood MJ (2010) Robot-assisted excision of ectopic mediastinal parathyroid adenoma. Asian Cardiovasc Thorac Ann 18(1):65–67

    PubMed  Google Scholar 

  42. Bodner J, Profanter C, Prommegger R, Greiner A, Margreiter R, Schmid T (2004) Mediastinal parathyroidectomy with the da Vinci robot: presentation of a new technique. J Thorac Cardiovasc Surg 127(6):1831–1832

    Article  PubMed  CAS  Google Scholar 

  43. Venissac N, Pop D, Mouroux J (2009) Video-assisted mediastinoscopy as a therapeutic tool. Surg Endosc 23(11):2466–2472

    Article  PubMed  Google Scholar 

  44. Ohno K, Kuwata K, Yamasaki Y, Yamasaki H, Hatanaka N, Yamamoto S (1997) Mediastinoscopic extirpation of mediastinal ectopic parathyroid gland. Ann Thorac Surg 64(1):238–240

    Article  PubMed  CAS  Google Scholar 

  45. Iacobone M, Mondi I, Viel G et al (2010) The results of surgery for mediastinal parathyroid tumors: a comparative study of 63 patients. Langenbecks Arch Surg 395:947–953

    Article  PubMed  Google Scholar 

  46. Adinolfi M, Browder W, Wallin JD, Jones JW (1983) Excision of mediastinal parathyroid gland by mediastinoscopy. South Med J 76(12):1496–1497

    Article  PubMed  CAS  Google Scholar 

  47. Ravipati NB, McLemore EC, Schlinkert RT, Argueta R (2008) Anterior mediastinotomy for parathyroidectomy. Am J Surg 195(6):799–802

    Article  PubMed  Google Scholar 

  48. Schlinkert RT, Whitaker MD, Argueta R (1991) Resection of select mediastinal parathyroid adenomas through an anterior mediastinotomy. Mayo Clin Proc 66(11):1110–1113

    PubMed  CAS  Google Scholar 

  49. Randone B, Costi R, Scatton O et al (2010) Thoracoscopic removal of mediastinal parathyroid glands: a critical appraisal of an emerging technique. Ann Surg 251(4):717–721

    Article  PubMed  Google Scholar 

  50. Ismail M, Maza S, Swierzy M et al (2010) Resection of ectopic mediastinal parathyroid glands with the da Vinci robotic system. Br J Surg 97(3):337–343

    Article  PubMed  CAS  Google Scholar 

  51. McNeill TM, Chamberlain JM (1966) Diagnostic anterior mediastinotomy. Ann Thorac Surg 2(4):532–539

    Article  PubMed  CAS  Google Scholar 

  52. Ginsberg RJ, Rice TW, Goldberg M, Waters PF, Schmocker BJ (1987) Extended cervical mediastinoscopy. A single staging procedure for bronchogenic carcinoma of the left upper lobe. J Thorac Cardiovasc Surg 94(5):673–678

    PubMed  CAS  Google Scholar 

  53. Zielinski M (2007) Transcervical extended mediastinal lymphadenectomy. Thorac Surg Clin 20(2):215–223

    Article  Google Scholar 

  54. Zielinski M (2007) Transcervical extended mediastinal lymphadenectomy: results of staging in two hundred fifty-six patients with non-small cell lung cancer. J Thorac Oncol 2(4):370–372

    Article  PubMed  Google Scholar 

  55. McHenry C, Walsh M, Jarosz H et al (1988) Resection of parathyroid tumor in the aorticopulmonary window without prior neck exploration. Surgery 104(6):1090–1094

    PubMed  CAS  Google Scholar 

  56. Corvera CU, Jablons D, Morita E, Clark OH (2004) Retrocardiac parathyroid tumor: a rare mediastinal site. Surgery 135(1):104–107

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anthony W. Kim M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kim, A.W., Detterbeck, F.C. (2012). Surgical Approaches to Mediastinal Parathyroid Glands. In: Oertli, D., Udelsman, R. (eds) Surgery of the Thyroid and Parathyroid Glands. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23459-0_35

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-23459-0_35

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-23458-3

  • Online ISBN: 978-3-642-23459-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics