Abstract
The mediastinal parathyroid gland typically results from the failure of the parathyroid glands to cease at their normal position adjacent to the thyroid gland during their descent from the third and fourth pharyngeal pouches. An understanding of the possible anatomic locations of the aberrant parathyroid glands as well as the anatomy of the mediastinum itself is important to developing an effective diagnostic and management strategy. Combining this knowledge with one or several of the preoperative localization techniques that exist can contribute to the successful localization and subsequent resection of an anomalous mediastinal parthyroid gland. The hyperfunctioning ectopic, mediastinal parathyroid gland can usually be addressed operatively through a neck approach. Occasionally though, a thoracic approach is needed and selecting the optimal thoracic approach is dependent upon accurate preoperative localization of the aberrant gland as well as the expertise of the surgeon. The objectives of this chapter are to provide an overview of the ectopic mediastinal parathyroid gland, discuss the associated localization techniques, and describe the open and minimally invasive approaches that can be used when performing a mediastinal parathyroidectomy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Wang C, Gaz RD, Moncure AC (1986) Mediastinal parathyroid exploration: a clinical and pathologic study of 47 cases. World J Surg 10(4):687–695
Nathaniels EK, Nathaniels AM, Wang CA (1970) Mediastinal parathyroid tumors: a clinical and pathological study of 84 cases. Ann Surg 171(2):165–170
Brennan MF, Marx SJ, Doppman J et al (1981) Results of reoperation for persistent and recurrent hyperparathyroidism. Ann Surg 194(6):671–676
Wang CA (1977) Parathyroid re-exploration. A clinical and pathological study of 112 cases. Ann Surg 186(2):140–145
Edis AJ, Sheedy PF, Beahrs OH, van Heerden JA (1978) Results of reoperation for hyperparathyroidism, with evaluation of Âpreoperative localization studies. Surgery 84(3):384–393
Scholz DA, Purnell DC, Woolner LB, Clagett OT (1973) Mediastinal hyperfunctioning parathyroid tumors: review of 14 cases. Ann Surg 178(2):173–178
Russell CF, Edis AJ, Scholz DA, Sheedy PF, van Heerden JA (1981) Mediastinal parathyroid tumors: experience with 38 tumors requiring mediastinotomy for removal. Ann Surg 193(6):805–809
Callender GG, Grubbs EG, Vu T et al (2009) The fallen one: the inferior parathyroid gland that descends into the mediastinum. J Am Coll Surg 208(5):887–893, discussion 93–95
O’Herrin JK, Weigel T, Wilson M, Chen H (2002) Radioguided parathyroidectomy via VATS combined with intraoperative parathyroid hormone testing: the surgical approach of choice for patients with mediastinal parathyroid adenomas? J Bone Miner Res 17(8):1368–1371
Russell CF, Grant CS, van Heerden JA (1982) Hyperfunctioning supernumerary parathyroid glands. An occasional cause of hyperparathyroidism. Mayo Clin Proc 57(2):121–124
Phitayakorn R, McHenry CR (2006) Incidence and location of ectopic abnormal parathyroid glands. Am J Surg 191(3):418–423
Conn JM, Goncalves MA, Mansour KA, McGarity WC (1991) The mediastinal parathyroid. Am Surg 57(1):62–66
Roslyn JJ, Gordon HE, Mulder DG (1983) Mediastinal parathyroid adenomas. A cause of persistent hyperparathyroidism. Am Surg 49(10):523–527
Akerstrom G, Malmaeus J, Bergstrom R (1984) Surgical anatomy of human parathyroid glands. Surgery 95(1):14–21
Prinz RA, Lonchyna V, Carnaille B, Wurtz A, Proye C (1994) Thoracoscopic excision of enlarged mediastinal parathyroid glands. Surgery 116(6):999–1004, discussion 1004–1005
Arnault V, Beaulieu A, Lifante JC et al (2010) Multicenter study of 19 aortopulmonary window parathyroid tumors: the Âchallenge of embryologic origin. World J Surg 34(9):2211–2216
Wang C, Mahaffey JE, Axelrod L, Perlman JA (1979) Hyperfunctioning supernumerary parathyroid glands. Surg Gynecol Obstet 148(5):711–714
Mendoza V, Ramirez C, Espinoza AE et al (2010) Characteristics of ectopic parathyroid glands in 145 cases of primary hyperparathyroidism. Endocr Pract 16:977–981
Alesina PF, Moka D, Mahlstedt J, Walz MK (2008) Thoracoscopic removal of mediastinal hyperfunctioning parathyroid glands: personal experience and review of the literature. World J Surg 32(2):224–231
Cupisti K, Dotzenrath C, Simon D, Roher HD, Goretzki PE (2002) Therapy of suspected intrathoracic parathyroid adenomas. Experiences using open transthoracic approach and video-assisted thoracoscopic surgery. Langenbecks Arch Surg 386(7):488–493
Gaz RD, Doubler PB, Wang CA (1987) The management of 50 unusual hyperfunctioning parathyroid glands. Surgery 102(6):949–957
Gold JS, Donovan PI, Udelsman R (2006) Partial median sternotomy: an attractive approach to mediastinal parathyroid disease. World J Surg 30(7):1234–1239
Norton JA, Schneider PD, Brennan MF (1985) Median sternotomy in reoperations for primary hyperparathyroidism. World J Surg 9(5):807–813
Rothmund M, Diethelm L, Brunner H, Kummerle F (1976) Diagnosis and surgical treatment of mediastinal parathyroid tumors. Ann Surg 183(2):139–145
Taguchi M, Endo S, Hasegawa T, Sato Y, Sohara Y (2006) Thoracoscopic findings of a small posterior mediastinal parathyroid adenoma. Asian Cardiovasc Thorac Ann 14(5):e86–e87
Curley IR, Wheeler MH, Thompson NW, Grant CS (1988) The challenge of the middle mediastinal parathyroid. World J Surg 12(6):818–824
Prescott JD, Udelsman R (2009) Remedial operation for primary hyperparathyroidism. World J Surg 33(11):2324–2334
Clark OH (1988) Mediastinal parathyroid tumors. Arch Surg 123(9):1096–1100
Medrano C, Hazelrigg SR, Landreneau RJ, Boley TM, Shawgo T, Grasch A (2000) Thoracoscopic resection of ectopic parathyroid glands. Ann Thorac Surg 69(1):221–223
Nilubol N, Beyer T, Prinz RA, Solorzano CC (2007) Mediastinal hyperfunctioning parathyroids: incidence, evolving treatment, and outcome. Am J Surg 194(1):53–56
Quiros RM, Warren W, Prinz RA (2004) Excision of a mediastinal parathyroid gland with use of video-assisted thoracoscopy, intraoperative 99mTc-sestamibi scanning, and intraoperative monitoring of intact parathyroid hormone. Endocr Pract 10(1):45–48
Akin H, Gunluoglu Z, Kara V, Melek H, Dincer I (2008) Mediastinal ectopic parathyroid adenoma: report of two cases successfully treated by VATS approach. Thorac Cardiovasc Surg 56(1):60–62
Onoda N, Ishikawa T, Yamada N et al (2002) Radioisotope-navigated video-assisted thoracoscopic operation for ectopic mediastinal parathyroid. Surgery 132(1):17–19
Burger AE, Skene AI, Lagattolla NR (2008) Thoracoscopic excision of mediastinal parathyroid adenomas: a report of two cases. Ann R Coll Surg Engl 90(2):W1–W5
Chen H, Mack E, Starling JR (2005) A comprehensive evaluation of perioperative adjuncts during minimally invasive parathyroidectomy: which is most reliable? Ann Surg 242(3):375–380, discussion 80–83
Ott MC, Malthaner RA, Reid R (2001) Intraoperative radioguided thoracoscopic removal of ectopic parathyroid adenoma. Ann Thorac Surg 72(5):1758–1760
Liu RC, Hill ME, Ryan JA Jr (2005) One-gland exploration for mediastinal parathyroid adenomas: cervical and thoracoscopic approaches. Am J Surg 189(5):601–604, discussion 5
Sukumar MS, Komanapalli CB, Cohen JI (2006) Minimally invasive management of the mediastinal parathyroid adenoma. Laryngoscope 116(3):482–487
Chae AW, Perricone A, Brumund KT, Bouvet M (2008) Outpatient video-assisted thoracoscopic surgery (VATS) for ectopic mediastinal parathyroid adenoma: a case report and review of the literature. J Laparoendosc Adv Surg Tech A 18(3):383–390
Timmerman GL, Allard B, Lovrien F, Hickey D (2008) Hyperparathyroidism: robotic-assisted thoracoscopic resection of a supernumerary anterior mediastinal parathyroid tumor. J Laparoendosc Adv Surg Tech A 18(1):76–79
Chan AP, Wan IY, Wong RH, Hsin MK, Underwood MJ (2010) Robot-assisted excision of ectopic mediastinal parathyroid adenoma. Asian Cardiovasc Thorac Ann 18(1):65–67
Bodner J, Profanter C, Prommegger R, Greiner A, Margreiter R, Schmid T (2004) Mediastinal parathyroidectomy with the da Vinci robot: presentation of a new technique. J Thorac Cardiovasc Surg 127(6):1831–1832
Venissac N, Pop D, Mouroux J (2009) Video-assisted mediastinoscopy as a therapeutic tool. Surg Endosc 23(11):2466–2472
Ohno K, Kuwata K, Yamasaki Y, Yamasaki H, Hatanaka N, Yamamoto S (1997) Mediastinoscopic extirpation of mediastinal ectopic parathyroid gland. Ann Thorac Surg 64(1):238–240
Iacobone M, Mondi I, Viel G et al (2010) The results of surgery for mediastinal parathyroid tumors: a comparative study of 63 patients. Langenbecks Arch Surg 395:947–953
Adinolfi M, Browder W, Wallin JD, Jones JW (1983) Excision of mediastinal parathyroid gland by mediastinoscopy. South Med J 76(12):1496–1497
Ravipati NB, McLemore EC, Schlinkert RT, Argueta R (2008) Anterior mediastinotomy for parathyroidectomy. Am J Surg 195(6):799–802
Schlinkert RT, Whitaker MD, Argueta R (1991) Resection of select mediastinal parathyroid adenomas through an anterior mediastinotomy. Mayo Clin Proc 66(11):1110–1113
Randone B, Costi R, Scatton O et al (2010) Thoracoscopic removal of mediastinal parathyroid glands: a critical appraisal of an emerging technique. Ann Surg 251(4):717–721
Ismail M, Maza S, Swierzy M et al (2010) Resection of ectopic mediastinal parathyroid glands with the da Vinci robotic system. Br J Surg 97(3):337–343
McNeill TM, Chamberlain JM (1966) Diagnostic anterior mediastinotomy. Ann Thorac Surg 2(4):532–539
Ginsberg RJ, Rice TW, Goldberg M, Waters PF, Schmocker BJ (1987) Extended cervical mediastinoscopy. A single staging procedure for bronchogenic carcinoma of the left upper lobe. J Thorac Cardiovasc Surg 94(5):673–678
Zielinski M (2007) Transcervical extended mediastinal lymphadenectomy. Thorac Surg Clin 20(2):215–223
Zielinski M (2007) Transcervical extended mediastinal lymphadenectomy: results of staging in two hundred fifty-six patients with non-small cell lung cancer. J Thorac Oncol 2(4):370–372
McHenry C, Walsh M, Jarosz H et al (1988) Resection of parathyroid tumor in the aorticopulmonary window without prior neck exploration. Surgery 104(6):1090–1094
Corvera CU, Jablons D, Morita E, Clark OH (2004) Retrocardiac parathyroid tumor: a rare mediastinal site. Surgery 135(1):104–107
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kim, A.W., Detterbeck, F.C. (2012). Surgical Approaches to Mediastinal Parathyroid Glands. In: Oertli, D., Udelsman, R. (eds) Surgery of the Thyroid and Parathyroid Glands. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23459-0_35
Download citation
DOI: https://doi.org/10.1007/978-3-642-23459-0_35
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-23458-3
Online ISBN: 978-3-642-23459-0
eBook Packages: MedicineMedicine (R0)