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Embryology and Surgical Anatomy of the Thyroid and Parathyroid Glands

  • William B. Stewart
  • Lawrence J. Rizzolo
Chapter

Abstract

The primordial thyroid gland is first identifiable during the fourth week of gestation, beginning as an endodermal invagination of the tongue at the site of the foramen cecum (Fig. 2.1). The foramen cecum lies where the midline intersects the sulcus terminalis, which divides the tongue into anterior two thirds (oral part) and posterior one third (pharyngeal part). The thyroid diverticulum begins its descent through the tongue carrying with it the thyroglossal duct. The path of descent carries the developing gland anterior to the hyoid bone and the larynx. During the descent in the fifth week, the superior part of the duct degenerates. By this time, the gland has achieved its rudimentary shape with two lobes connected by an isthmus. It continues to descend until it reaches the level of the cricoid cartilage at about the seventh week. By the 12th week of development, thyroid hormone is secreted. The distal part of the thyroglossal duct degenerates but may remain as a pyramidal lobe.

Keywords

Parathyroid Gland Recurrent Laryngeal Nerve Laryngeal Nerve Cricoid Cartilage Inferior Thyroid Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Abboud B, Aouad R (2004) Non-recurrent inferior laryngeal nerve in thyroid surgery: report of three cases and review of the literature. J Laryngol Otol 118:139–142PubMedCrossRefGoogle Scholar
  2. 2.
    Bellantone R, Boscherini M, Lombardi CP et al (2001) Is the identification of the external branch of the superior laryngeal nerve mandatory in thyroid operation? Results of a prospective randomized study. Surgery 130:1055–1059PubMedCrossRefGoogle Scholar
  3. 3.
    Droulias C, Tzinas S, Tzinas S et al (1976) The superior laryngeal nerve. Am Surg 42:635–638PubMedGoogle Scholar
  4. 4.
    Dyson MD (1995) Endocrine system. In: Williams PL (ed) Gray’s anatomy. Churchill Livingstone, New York, pp 1881–1906Google Scholar
  5. 5.
    Fang G, Guidroz JA, O’Malley Y et al (2010) Expansion of a cell population expressing stem cell markers in parathyroid glands from patients with hyperparathyroidism. Ann Surg 251:107–113PubMedCrossRefGoogle Scholar
  6. 6.
    Ghanem N, Bley T, Altehoefer C et al (2003) Ectopic thyroid gland in the porta hepatis and lingua. Thyroid 13:503–507PubMedCrossRefGoogle Scholar
  7. 7.
    Klonisch T, Hoang-Vu C, Hombach-Klonisch S (2009) Thyroid stem cells and cancer. Thyroid 19:1303–1315PubMedCrossRefGoogle Scholar
  8. 8.
    Larsen WJ (2001) Human embryology. Churchill Livingstone, New YorkGoogle Scholar
  9. 9.
    LiVolsi VA (1990) Surgical pathology of the thyroid. Saunders, PhiladelphiaGoogle Scholar
  10. 10.
    Mirilas P, Skandalakis JE (2002) Benign anatomical mistakes: the correct anatomical term for the recurrent laryngeal nerve. Am Surg 68:95–97PubMedGoogle Scholar
  11. 11.
    Page C, Foulon P, Strunski V (2003) The inferior laryngeal nerve: surgical and anatomic considerations. Report of 251 thyroidectomies. Surg Radiol Anat 25:188–191PubMedCrossRefGoogle Scholar
  12. 12.
    Roth LM, Talerman A (2007) The enigma of struma ovarii. Pathology 39:139–146PubMedCrossRefGoogle Scholar
  13. 13.
    Shaheen OH (2003) Thyroid surgery. Parthenon Publishing, New YorkGoogle Scholar
  14. 14.
    Shen W, Duren M, Shen W et al (1996) Reoperation for persistent or recurrent primary hyperparathyroidism. Arch Surg 131:861–867; discussion 867–869PubMedCrossRefGoogle Scholar
  15. 15.
    Sherman JH, Colborn GL (2003) Absence of the left inferior thyroid artery: clinical implications. Clin Anat 16:534–537PubMedCrossRefGoogle Scholar
  16. 16.
    Skandalakis JE, Carlson GW, Colborn GL et al (2004) Neck. In: Skandalakis JE (ed) Surgical anatomy, vol 1. Paschalidis Medical, Athens, pp 3–116Google Scholar
  17. 17.
    Sturniolo G, D’Alia C, Tonante A et al (1999) The recurrent laryngeal nerve related to thyroid surgery. Am J Surg 177:485–488PubMedCrossRefGoogle Scholar
  18. 18.
    Toni R, Della Casa C, Mosca S et al (2003) Anthropological variations in the anatomy of the human thyroid arteries. Thyroid 13:183–192PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of SurgeryYale University School of MedicineNew HavenUSA

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