Andrographolide: A Renoprotective Diterpene from Andrographis Paniculata (Burm. f.) Nees

  • P. Singh
  • M. M. Srivastava
  • D. K. Hazra
  • L. D. Khemani

Abstract

Andrographis paniculata Nees, a well-known plant of Indian and Chinese traditional system of medicines, has drawn attention of researchers in recent times. An attempt was made to isolate the active principle from the plant using chromatographic methods. Andrographolide isolated from Andrographis paniculata (burm. f.) Nees (Acanthaceae) ameliorated the diabetes induced renal failure when treated for 28 days. The results demonstrated that andrographolide showed alleviation in terms of serum creatinine (54.73 %), serum urea (63.92 %), urinary proteins (32.35 %) at a dose of 90 μg/ml. The structure of the isolated compound was confirmed by various spectroscopic methods.

Keywords

Diabetic Nephropathy Serum Urea MeOH Extract Andrographis Paniculata Free Radical Scavenge Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • P. Singh
    • 1
  • M. M. Srivastava
    • 1
  • D. K. Hazra
    • 2
  • L. D. Khemani
    • 1
  1. 1.Department of ChemistryDayalbagh Educational Institute (Deemed University)AgraIndia
  2. 2.Nuclear Medicine UnitS. N. Medical CollegeAgraIndia

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