Synthesis, Characterization, Anti-Tumor and Anti-Microbial Activity of Fatty Acid Analogs of Propofol

  • A. Mohammad
  • F. B. Faruqi
  • J. Mustafa


Derivatives of propofol (2, 6-diisopropylphenol) were prepared by coupling with 12-hydroxy-octadec-Z-9-enoic acid and Z-9-octadecenoic acid (oleic acid) with the C1-α-hydroxy function of propofol. Spectroscopic studies confirmed the formation of the desired product. The compounds were then investigated for its in-vitro anticancer activity against a panel of solid human tumor cell lines including human malignant melanoma, human leukemia cells. Their cytotoxicity was also determined against non-cancerous mammalian cells (VERO cells). The analogs were cytotoxic against all cancer cell lines whereas no effect was observed against normal cells. The compounds showed good antimicrobial activity against E. coli and S. albus.


VERO Cell Ricinoleic Acid Solid Tumor Cell Line Fatty Acid Conjugate Olefin Proton 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    T. Mammoto, M. Mukai, A. Mammoto, Y. Yamanaka, Y. Hayashi, T. Mashimo, Y. Kishi and H. Nakamura; Cancer Lett. 184 (2002) 165.CrossRefGoogle Scholar
  2. 2.
    R.A. Siddiqui, M. Zerouga, M. Wu, A. Castillo, K. Harvey, G.P. Zaloga and W. Stillwell; Breast Cancer Res. 7 (2005) 645. CrossRefGoogle Scholar
  3. 3.
    D.D. Ross, P.J. Wooten, Y. Tong, B. Cornblatt, C. Levy, R. Sridhara, E.J. Lee and C.A. Schiffer; Blood. 83 (1994) 1337.Google Scholar
  4. 4.
    F.D. Gunstone; J. Chem. Soc. (1954) 1611.Google Scholar
  5. 5.
    A. Mohammad, F.B. Faruqi and J. Mustafa; J. Adv. Sci. Res. 1 (2010) 12. Google Scholar
  6. 6.
    E. Borenfreund, H. Babich and N. Martin-Alguacil; In vitro Dev. Cell. Biol. 26 (1990) 1030.Google Scholar
  7. 7.
    A.L. Barry, P.D. Hoeprich and M.A. Saubolle. Eds. 4th. LBS, Lea & Febiger, Philadelphia, (1976) p. 180–193.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • A. Mohammad
    • 1
  • F. B. Faruqi
    • 1
  • J. Mustafa
    • 2
  1. 1.Department of Applied Chemistry, Faculty of Engineering and TechnologyAligarh Muslim UniversityAligarhIndia
  2. 2.Department of PharmacognosyKing Saud UniversityRiyadhSaudi Arabia

Personalised recommendations