Synthesis, Characterization, Anti-Tumor and Anti-Microbial Activity of Fatty Acid Analogs of Propofol
Derivatives of propofol (2, 6-diisopropylphenol) were prepared by coupling with 12-hydroxy-octadec-Z-9-enoic acid and Z-9-octadecenoic acid (oleic acid) with the C1-α-hydroxy function of propofol. Spectroscopic studies confirmed the formation of the desired product. The compounds were then investigated for its in-vitro anticancer activity against a panel of solid human tumor cell lines including human malignant melanoma, human leukemia cells. Their cytotoxicity was also determined against non-cancerous mammalian cells (VERO cells). The analogs were cytotoxic against all cancer cell lines whereas no effect was observed against normal cells. The compounds showed good antimicrobial activity against E. coli and S. albus.
KeywordsVERO Cell Ricinoleic Acid Solid Tumor Cell Line Fatty Acid Conjugate Olefin Proton
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