Evaluation of Assam Bora Rice as a Natural Mucoadhesive Matrixing Agent for Controlled Drug Delivery

  • Nikhil K. Sachan
  • S. Pushkar
  • S. K. Ghosh


The Present study envisages pharmaceutical utility of Assam Bora rice as biopolymeric excipient in drug delivery. The sustained release potential from the proposed matrix backbone was investigated through in vitro dissolution studies of microbeads prepared by an industrially feasible conventional ionotropic gelation method using the blends of pregelatinized Bora rice along with sodium alginate, as per SUPAC-MR guidelines. The prepared beads were characterized for surface morphology, drug-polymer compatibility, mucoadhesion and other pharmacotechnical parameters. The outcomes of studies have demonstrated that Assam Bora rice holds the promise of being used as a drug release modulator in the drug carrier systems.


Drug Release Sodium Alginate Entrapment Efficiency Mucoadhesive Property Glutinous Rice 
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  1. 1.
    N. Kashyap, S. Modi, J.P. Jain, I. Bala, S. Hariharan, R. Bhardwaj, D. Singh, R. Mahajan, N. Kumar, M.N.V. Ravi Kumar; CRIPS 5, 3 (2004) 7–12.Google Scholar
  2. 2.
    J.K. Vasir, K. Tambwekar and S. Garg; Int. J. Pharm. 255 (2003) 13–32.CrossRefGoogle Scholar
  3. 3.
    M.P. Satturwar, V.S. Fulzele and A.K. Dorle; AAPS Pharm SciTech, 4, 4 (2003) Article 55.Google Scholar
  4. 4.
    S. Suzuki, et al.; Biomacromolecules, 6 (2005) 3238–3242.CrossRefGoogle Scholar
  5. 5.
    P.K. Pathak, T. Ahmed, K.K. Sharma and A.K. Pathak; 32 (1995) 48–50.Google Scholar
  6. 6.
    B.O. Juliano, In Proceedings of a Workshop on Chemical Aspects of Rice Grain Quality. International Rice Research Institute, Los Banos, Laguna, Philippines (1979) 251–256.Google Scholar
  7. 7.
    C. Rados; FDA Consumer Magazine. 2004 (March-April). Google Scholar
  8. 8.
    C.M. Lehr, J.A. Bouwstra, E.H. Schacht and H.E. Junginger; Int. J. Pharm. 78 (1992) 43–48.CrossRefGoogle Scholar
  9. 9.
    A. Paharia, A.K. Yadav, G. Rai, S.K. Jain, S.S. Pancholi and G.P. Agrawal; AAPS PharmSciTech; 8 (2007) 12.CrossRefGoogle Scholar
  10. 10.
    K.C. Gupta and M.N.V. Ravi Kumar; J. Mater. Sci.: Mater. Med. 12 (2001) 753- 759.CrossRefGoogle Scholar
  11. 11.
    APhA: Hand Book of Pharmaceutical Excipient, 10th Ed. American Pharmaceutical Association. Pharmaceutical Society of Great Britain. England (1983) 364.Google Scholar
  12. 12.
    M. Asarafi, J.A. Chowdhary and S.M. Reza; J. Pharm Sci. 4, 1 (2005).Google Scholar
  13. 13.
    R.P. Patel, et al.; Drug Delivery, 5, 1 (2005).Google Scholar
  14. 14.
    FDA Guidance for Industry, Center for Drug Evaluation and Research (CDER), Sept 1997.Google Scholar
  15. 15.
    P.T. Tayade and R.D. Kale; AAPS PharmSciTech 6, 1 (2004).Google Scholar
  16. 16.
    M. Scherlund, PhD Thesis, Faculty of Pharmacy, Uppasala University, Sweden; 2000.Google Scholar
  17. 17.
    G.H. Stout, L.H. Jensen; X-ray Structure Determination. A Practical Guide. John Wiley and Sons, Inc. New York (1989).Google Scholar
  18. 18.
    V. Luzzati; Xray diffraction studies of lipidwater systems. In: D Chapman (Ed.) Biological Membranes. Academic Press, New York (1968) 71–123. Google Scholar
  19. 19.
    K. Fontell; Adv. Colloid Interface Sci.; 41 (1992) 127–47.CrossRefGoogle Scholar
  20. 20.
    K. Larsson: Lipids-Molecular Organization, Physical Functions and Technical Applications. Vol. III. Scotland: The Oily Press Ltd, West Ferry, Dundee (1994).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Nikhil K. Sachan
    • 1
  • S. Pushkar
    • 1
  • S. K. Ghosh
    • 2
  1. 1.University Institute of PharmacyC. S. J. M. UniversityKanpurIndia
  2. 2.Department of Pharmaceutical SciencesDibrugarh UniversityDibrugarhIndia

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