Abstract
The description of multiscale processes in a unified and coherent fashion is of paramount importance in cardiovascular computational physiology. In this paper, a model that links the process of cardiac excitation and contraction from a cellular to a tissue level will be presented. A model of the action potential will be linked to the kinetics (attachment and detachment) of the proteins responsible for cardiac contraction (via the so called “crossbridges mechanism”). As a final step, the coupling of the calcium-dependent kinetics model to a higher-scale model of the left ventricle will complete the multi-scale model of cardiac dynamics from the sub-cellular level to the organ.
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© 2011 Springer-Verlag Berlin Heidelberg
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Bhattacharya-Ghosh, B., Schievano, S., Díaz-Zuccarini, V. (2011). Integration of the Calcium Dynamics in the Excitation Contraction Coupling Process within a Multiscale Model of the Left Ventricle. In: Vlad, S., Ciupa, R.V. (eds) International Conference on Advancements of Medicine and Health Care through Technology. IFMBE Proceedings, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22586-4_56
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DOI: https://doi.org/10.1007/978-3-642-22586-4_56
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-22585-7
Online ISBN: 978-3-642-22586-4
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