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Renaissance of the Regulatory RNAs

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Regulatory RNAs

Abstract

“Non-coding RNAs (ncRNAs)” originate from various types of regulatory DNA, which lie deep in the wilderness of so-called junk DNA present within the genomes. Far from being humble messengers, a group of ncRNAs are powerful players in how genomes operate and are better termed as “regulatory RNAs”. The new regulatory role of RNA began to emerge recently as researchers discovered different classes of regulatory RNA molecules, namely, small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), long noncoding RNAs (lncRNAs), etc. These versatile RNA molecules appear to comprise a hidden layer of internal signals that control various levels of gene expression in physiology and development, including chromatin architecture/epigenetic memory, transcription, RNA splicing, editing, translation, and turnover. RNA regulatory networks may determine most of our complex characteristics, play a significant role in diseases, and constitute an unexplored world of genetic variation both within and between species. In this chapter, we have attempted to provide a snapshot of the entire landscape of these versatile molecules.

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Authors and Affiliations

  1. Bose Institute, Kolkata, India

    Zhumur Ghosh

  2. New York State Department of Health, Wadsworth Center, Albany, NY, USA

    Bibekanand Mallick

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  1. Zhumur Ghosh
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  2. Bibekanand Mallick
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  1. , New York State Department of Health, Wadsworth Center, New Scotland Avenue 120, New York, 12208, New York, USA

    Bibekanand Mallick

  2. A.J.C. Bose Centenary Building, P-1/12, CIT Scheme - VII M, Bose Institute, Kolkata, 700054, India

    Zhumur Ghosh

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Ghosh, Z., Mallick, B. (2012). Renaissance of the Regulatory RNAs. In: Mallick, B., Ghosh, Z. (eds) Regulatory RNAs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22517-8_1

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