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Selenophosphate Synthetase

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Selenoproteins and Mimics

Part of the book series: Advanced Topics in Science and Technology in China ((ATSTC))

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Abstract

Selenoproteins are a group of selenocysteine-containing proteins, which play important roles from bacteria to metazoans. Their active site is selenocysteine, the 21st amino acid, encoded by the UGA stop codon. In incorporating selenocysteine into selenoproteins, an important enzyme, selenophosphate synthetase (SPS), the product of the SelD gene, is needed. Selenophosphate synthetase produces an activated form of selenium, selenophosphate, which is used for charging the serine-tRNA Sec with Se by selenocysteine synthetase (SelA), resulting in the specific selenocystyl-tRNA Sec. In the present review, we describe the structural properties and catalytic mechanism of selenophosphate synthetase, and discuss its significant role in selenoprotein syntheses and cell proliferation.

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Authors and Affiliations

  1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 130012, Changchun, China

    Chunqiu Zhang & Junqiu Liu

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  1. Chunqiu Zhang
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  2. Junqiu Liu
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© 2011 Zhejiang University Press, Hangzhou and Springer-Verlag Berlin Heidelberg

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Zhang, C., Liu, J. (2011). Selenophosphate Synthetase. In: Selenoproteins and Mimics. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22236-8_4

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