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Selenoproteins and Mimics pp 259–277Cite as

Selenium-containing Catalytic Antibodies

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Part of the book series: Advanced Topics in Science and Technology in China ((ATSTC))

Abstract

As an essential trace element, selenium is closely related to human health and disease, especially the unique role in selenoenzyme glutathione peroxidase (GPx). GPx is a well-known selenoenzyme that functions as an antioxidant and catalyzes the reduction of harmful peroxide by glutathione and protects cells against oxidative damage. However, the shortcomings of native GPx, such as instability and poor availability, have limited its application. Many GPx mimics have been developed, but they have serious disadvantages. They are short of substrate binding sites, preventing them from firmly binding to the glutathione (GSH) substrate. Nevertheless, a substrate binding site can be easily generated using standard monoclonal antibody preparation technique if substrate analog is used as hapten. In this chapter, we introduce the preparation and antioxidant effects of selenium-containing catalytic antibodies, including mouse/human seleniumcontaining a monoclonal antibody (McAb) and single-chain variable fragments of antibodies (scFv) with GPx activities.

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Authors and Affiliations

  1. Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, 310058, Hangzhou, China

    Ying Mu

  2. Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, 130012, Changchun, China

    Yawei Xu & Ying Mu

Authors
  1. Yawei Xu
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  2. Ying Mu
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© 2011 Zhejiang University Press, Hangzhou and Springer-Verlag Berlin Heidelberg

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Xu, Y., Mu, Y. (2011). Selenium-containing Catalytic Antibodies. In: Selenoproteins and Mimics. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22236-8_17

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