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Modeling Pharmacokinetics and Pharmacodynamics on a Mobile Device to Help Caffeine Users

  • Frank E. Ritter
  • Kuo-Chuan (Martin) Yeh
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6780)

Abstract

We introduce a mobile device application that displays key information about caffeine: the pharmacokinetics (time course of drug levels) and pharmacodynamics (the effects of caffeine level) visually on the iPhone, iPod Touch, and iPad. This application, Caffeine Zone, is based on an existing model of caffeine physiology using user inputs, including caffeine dose, start time, and consumption speed. It calculates the caffeine load in a user for the next twenty-four hours and displays it using a line chart. In addition, it shows whether the user is currently in the “cognitive alert zone” (the range of caffeine where a normal person might benefit most from caffeine) or the “possible sleep zone” (the range of caffeine where sleep is presumed not affected by caffeine level.) Understanding the pharmacokinetics and pharmacodynamics of caffeine can help people using caffeine to improve alertness, including in operational environments. Caffeine Zone may also help users create a mental model of caffeine levels when the device is not available. We argue that this app will both teach users the complex absorption/elimination process of caffeine and help monitor users’ daily caffeine usage. The model, with additional validation, can be part of a system that predict cognitive state of users and provide assistances in critical conditions.

Keywords

pharmacokinetics pharmacodynamics caffeine mobile app modeling 

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References

  1. 1.
    Kendler, K.S., Prescott, C.A.: Caffeine Intake, Tolerance, and Withdrawal in Women: A Population-Based Twin Study. American Journal of Psychiatry 156, 223–228 (1999)Google Scholar
  2. 2.
    Fredholm, B.B., Batting, K., Holmen, J., Nehlig, A., Zvartau, E.E.: Actions of Caffeine in the Brain with Special Reference to Factors that Contribute to its Widespread Use. Pharmacological Reviews 55(1), 83–133 (1999)Google Scholar
  3. 3.
    Horne, J.A., Reyner, L.A.: Counteracting Driver Sleepiness: Effects of Napping, Caffeine, and Placebo. Psychophysiology 33(3), 306–309 (1996)CrossRefGoogle Scholar
  4. 4.
    Institute of Medicine: Caffeine for the Sustainment of Mental Task Performance. National Academy Press, Washington, DC (2001)Google Scholar
  5. 5.
    Klein, L.C., Bennett, J.M., Whetzel, C.A., Granger, D.A., Ritter, F.E.: Caffeine and Stress Alter Salivary α-Amylase Levels in Young Men. Human Psychopharmacology: Clinical and Experimental 25, 359–367 (2010)CrossRefGoogle Scholar
  6. 6.
    Hughes, R.N.: Drugs which Induce Anxiety: Caffeine. New Zealand Journal of Psychology 25(1), 36–42 (1996)Google Scholar
  7. 7.
    Naval Aerospace Medical Research Laboratory: Performance Maintenance During Continuous Flight Operations: A Guide for Flight Surgeons, Vol. NAVMED P-6410. Naval Strike and Air Warfare Center (2000)Google Scholar
  8. 8.
    Morgan, G.P., Ritter, F.E., Stine, M.M., Klein, L.C.: The Cognitive Effects of Caffeine: Implications for Models of Users: unpublished mss (2006)Google Scholar
  9. 9.
    Seng, K.-Y., Fun, C.-Y., Law, Y.-L., Lim, W.-M., Fan, W., Lim, C.-L.: Population Pharmacokinetics of Caffeine in Healthy Male Adults Using Mixed-Effects Model. Journal of Clinical Pharmacy and Therapeutics 34, 103–114 (2009)CrossRefGoogle Scholar
  10. 10.
    James, J.E.: Understanding Caffeine: A Biobehavioral Analysis. Sage, Thousand Oaks (1997)Google Scholar
  11. 11.
    Julien, R.M.: The Primer of Drug Action. Worth Publishers, New York (2001)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Frank E. Ritter
    • 1
  • Kuo-Chuan (Martin) Yeh
    • 1
  1. 1.The Pennsylvania State UniversityUSA

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