Skip to main content
SpringerLink
Log in

The Impact of Radiation Quality on Cure Rate

  • Chapter
  • First Online:
Ion Beam Therapy

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL,volume 320))

  • 1996 Accesses

Abstract

Radiobiological data indicate that high-LET radiations are more effective than low-LET radiations in treating hypoxic, well differentiated, and slowly growing tumors. The clinical outcomes of fast neutron therapy still serve as the basis for the selection of ion beam therapy (IBT). Patient selection is a complex issue and robust predictive tests are needed and in development but not presently validated. Randomized clinical trials comparing modern high- and low-LET radiotherapy machines and treatment planning systems should be organized. For this, protocols and outcomes should be described, reported, and analyzed applying internationally accepted terminology, concepts, and approaches.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. D.T. Goodhead, Radiation effects in living cells. Can. J. Phys. 68, 872–886 (1990)

    Article  ADS  Google Scholar 

  2. M. Tubiana, Radiobiologie, Radiothérapie et Radioprotection (Hermann Médecine, Paris, 2008)

    Google Scholar 

  3. International Commission on Radiation Units and Measurements (ICRU) and International Atomic Energy Agency (IAEA). Prescribing, recording and reporting proton-beam therapy. ICRU Report 78, jointly with the IAEA. J ICRU 7 (2007)

    Google Scholar 

  4. J. Gueulette, M. Octave-Prignot, B.M. De Coster, et al., Intestinal crypt cell regeneration in mice: a biological system for quality assurance in non-conventional radiation therapy. Radiother. Oncol. 73(Suppl 2), S148–S154 (2004)

    Article  Google Scholar 

  5. T. Loncol, V. Cosgrove, J.M. Denis, et al., Radiobiological effectiveness of radiation beams with broad LET spectra: Microdosimetric analysis using biological weighting factors. Radiat. Protect. Dosim. 52, 347–352 (1994)

    Google Scholar 

  6. H.G. Menzel, P. Pihet, A. Wambersie, Microdosimetric specification of radiation quality in neutron radiation therapy. Int. J. Radiat. Biol. 57, 865–883 (1990)

    Article  Google Scholar 

  7. Bureau International des Poids et Mesures (BIPM), The International System of Units (SI), 8th edn. (BIPM, 92312 Sèvres Cedex, 2006)

    Google Scholar 

  8. International Commission on Radiation Units and Measurements (ICRU), Clinical Proton Dosimetry – Part 1: Beam Production, Beam Delivery and Measurement of Absorbed Dose. ICRU Report 59 (ICRU, Bethesda, MD, USA, 1998)

    Google Scholar 

  9. International Commission on Radiation Units and Measurements (ICRU), Prescribing, Recording and Reporting Photon Beam Therapy: Supplement to ICRU Report 50. ICRU Report 62 (ICRU, Bethesda, MD, USA, 1999)

    Google Scholar 

  10. International Commission on Radiation Units and Measurements (ICRU), Prescribing, Recording and Reporting Intensity-Modulated Photon-Beam Therapy (IMRT). ICRU Report 83, J ICRU (in press)

    Google Scholar 

  11. International Commission on Radiation Units and Measurements (ICRU), Prescribing, Recording and Reporting Electron Beam Therapy. ICRU Report 71, Journal of the ICRU (Oxford University press, Oxford, 2004)

    Google Scholar 

  12. International Atomic Energy Agency (IAEA) and International Commission on Radiation Units and Measurements (ICRU), Relative biological effectiveness in ion-beam therapy. IAEA-Technical Report Series 461 (IAEA, Vienna, Austria, 2008)

    Google Scholar 

  13. International Commission on Radiological Protection (ICRP), Report of the RBE Subcommittee to the International Commission on Radiological Protection (ICRP) and the International Commission on Radiation Units and Measurements (ICRU). Health Phys. 9, 357–386 (1963)

    Google Scholar 

  14. International Commission on Radiation Units and Measurements (ICRU). Prescribing, Recording and Reporting Photon Beam Therapy. ICRU Report 50 (ICRU, Bethesda, MD, USA, 1993)

    Google Scholar 

  15. J.H. Hendry, Quantitation of the radiotherapeutic importance of naturally-hypoxic normal tissues from collated experiments with rodents using single doses. Int. J. Radiat. Oncol. Biol. Phys. 5, 971–976 (1979)

    Google Scholar 

  16. G.W. Barendsen, The relationship between RBE and LET for different types of lethal damage in mammalian cells: biophysical and molecular mechanisms. Radiat. Res. 139, 257–270 (1994)

    Article  Google Scholar 

  17. A. Wambersie, J.H. Hendry, J. Gueulette, et al., Radiobiological rationale and patient selection for high-LET radiation in cancer therapy. Radiother. Oncol. 73(Suppl 2), S1–S14 (2004)

    Article  Google Scholar 

  18. H.B. Stone, J.M. Brown, T.L. Phillips, R.M. Sutherland, Oxygen in human tumors: correlations between methods of measurements and response to therapy. Radiat. Res. 136, 422–434 (1993)

    Article  Google Scholar 

  19. J.A. Raleigh, M.W. Dewhirst, D.E. Thrall, Measuring tumor hypoxia. Sem. Radiat. Oncol. 6, 37–45 (1996)

    Article  Google Scholar 

  20. S.M. Evans, A.V. Kachur, C.Y. Shiue, et al., Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1. J. Nucl. Med. 41, 327–336 (2000)

    Google Scholar 

  21. P. Mahy, M. De Bast, P.h. Levêque, et al., Preclinical validation of the hypoxic tracer 2-(2 nitroimidazol-1- yl)-N-(3,3,3-[18F]trifluoropropyl)-acetamide, [18F]-EF3. Eur. J. Nucl. Med. Mol. Imaging 3, 1263–1272 (2004)

    Google Scholar 

  22. E.J. Hall, A. Kellerer, Review of RBE Data for Cells in Culture, in High LET Radiations in Clinical Radiotherapy. ed. by G.W. Barendsens, J. Broerse, K. Breur. (Pergamon, Oxford, 1979), pp. 171–174

    Google Scholar 

  23. A. Uzawa, K. Ando, S. Koike, et al., Comparison of biological effectiveness of carbon-ion beams in Japan and Germany. Int. J. Radiat. Oncol. Biol. Phys. 73, 1545–1551 (2009)

    Article  Google Scholar 

  24. A. Uzawa, K. Ando, Y. Furusawa, et al., Biological intercomparison using gut crypt survivals for proton and carbon-ion beams. J. Radiat. Res. 48(Suppl A), A75–A80 (2007)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Université Catholique de Louvain, UCL – IMRE 5469, Av Hippocrate 55, 1200, Brussels, Belgium

    John Gueulette & André Wambersie

  2. Department of Radiation Medicine, A.G. James Cancer Hospital & R. Solove Research Institute, Ohio State University Medical Center, Columbus, OH, 43210, USA

    Reinhard Gahbauer

  3. iThemba LABS, 722, Somerset West, 7129, South Africa

    Dan T. L. Jones & Jacobus Slabbert

Authors
  1. John Gueulette
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Reinhard Gahbauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dan T. L. Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jacobus Slabbert
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. André Wambersie
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to John Gueulette .

Editor information

Editors and Affiliations

  1. Forschungszentrum Jülich, Jülich, 52425, Germany

    Ute Linz

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gueulette, J., Gahbauer, R., Jones, D.T.L., Slabbert, J., Wambersie, A. (2012). The Impact of Radiation Quality on Cure Rate. In: Linz, U. (eds) Ion Beam Therapy. Biological and Medical Physics, Biomedical Engineering, vol 320. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21414-1_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-21414-1_6

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-21413-4

  • Online ISBN: 978-3-642-21414-1

  • eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)

Publish with us

Policies and ethics

Search

Navigation