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Evolutionary Protein Contact Maps Prediction Based on Amino Acid Properties

  • Alfonso E. Márquez Chamorro
  • Federico Divina
  • Jesús S. Aguilar-Ruiz
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6679)

Abstract

Protein structure prediction is one of the main challenges in Bioinformatics. An useful representation for protein 3D structure is the protein contact map. In this work, we propose an evolutionary approach for contact map prediction based on amino acids physicochemical properties. The evolutionary algorithm produces a set of rules that identifies contacts between amino acids. The rules obtained by the algorithm imposes a set of conditions on four amino acid properties in order to predict contacts. Results obtained confirm the validity of the proposal.

Keywords

Protein Structure Prediction Contact Map Evolutionary Computation Residue-residue Contact 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Alfonso E. Márquez Chamorro
    • 1
  • Federico Divina
    • 1
  • Jesús S. Aguilar-Ruiz
    • 1
  1. 1.School of EngineeringPablo de Olavide University of SevillaSpain

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