Zusammenfassung
α2-Agonisten zogen in den letzten Jahren wegen ihrer sedativ-hypnotischen, analgetischen und vegetativ dämpfenden Eigenschaften in der klinischen Anästhesie große Aufmerksamkeit auf sich. Im Rahmen der perioperativen Anwendung von Clonidin als Antihypertensivum fiel auf, dass sich der Bedarf von Hypnotika und Analgetika deutlich verringerte, bei gleichzeitig verbesserter hämodynamischer und sympathoadrenerger Stabilität.
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Literatur
Asano T, Dohi S, Ohta S, Shimonaka H, Iida H (2000) Antinociception by epidural and systemic alpha(2)-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth Analg 90: 400–407
Bergese SD, Candiotti KA, Bokesch PM et al. (2010).A Phase IIIb, randomized, double-blind, placebo-controlled, multicenter study evaluating the safety and efficacy of dexmedetomidine for sedation during awake fiberoptic intubation. Am J Ther 17: 586–595
Bhana N, Goa KL, McClellan KJ (2000) Dexmedetomidine. Drugs 59: 263–268
Bock M, Kunz P, Schreckenberger R et al. (2002) Comparison of caudal and intravenous clonidine in the prevention of agitation after sevoflurane in children. Br J Anaesth 88: 790–796
Candiotti KA, Bergese SD, Bokesch PM et al. (2010) Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial. Anesth Analg 110: 47–56
Crassous PA, Denis C, Paris H, Senard JM (2007) Interest of alpha2-adrenergic agonists and antagonists in clinical practice: background, facts and perspectives. Curr Top Med Chem 7: 187–194
Dahmani S, Brasher C, Stany I et al. (2010) Premedication with clonidine is superior to benzodiazepines. A meta analysis of published studies. Acta Anaesthesiol Scand 54: 397–402
Danelli G, Nuzzi M, Salcuni PF et al. (2006) Does clonidine 50 microg improve cervical plexus block obtained with ropivacaine 150 mg for carotid endarterectomy? A randomized, double-blinded study. J Clin Anesth 18: 585–588
Elia N, Culebras X, Mazza C, Schiffer E, Tramèr MR (2008) Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials. Reg Anesth Pain Med 33: 159–167
El-Kerdawy HM, Zalingen EE, Bovill JG (2000) The influence of the alpha2-adrenoceptor agonist, clonidine, on the EEG and on the MAC of isoflurane. Eur J Anaesthesiol 17: 105–110
Gerlach AT, Murphy CV, Dasta JF (2009) An updated focused review of dexmedetomidine in adults. Ann Pharmacother. 43: 2064–2074
Gowing L, Ali R, White J (2006) Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal. Cochrane Database Syst Rev 19: CD002022
Huang R, Chen Y, Yu AC, Hertz L (2000) Dexmedetomidine-induced stimulation of glutamine oxidation in astrocytes: a possible mechanism for ist neuroprotective activity. J Cereb Blood Flow Metab 20: 895–898
Huang R, Hertz L (2000) Receptor subtype and dose dependence of dexmedetomidine-induced accumulation of glutamine in astrocytes suggests glial involvement in its hypnotic-sedative and anestheticsparing effects. Brain Res 873: 297–301
Kita T, Kagawa K, Mammoto T et al. (2000) Supraspinal, not spinal, alpha(2) adrenoceptors are involved in the anesthetic-sparing and hemodynamic-stabilizing effects of systemic clonidine in rats. Anesth Analg 90: 722–726
Klein SM, Nielsen KC (2003) Brachial plexus blocks: infusions and other mechanisms to provide prolonged analgesia. Curr Opin Anaesthesiol 16: 393–399
Maze M, Masahiko F (2000) α2-Adrenoceptors in pain modulation (Editorial). Anesthesiology 92: 934–936
Mantz J, Josserand J, Hamada S. (2011) Dexmedetomidine: new insights. Eur J Anaesthesiol.28: 3–6
Piper SN, Maleck WH, Boldt J et al. (2000) A comparison of urapidil, clonidine, meperidine and placebo in preventing postanesthetic shivering. Anesth Analg 90: 954–957
Riker RR, Shehabi Y, Bokesch PM et al. (2009) Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 301: 489–499
Segal IS, Vickery RG, Walton JK, Doze VA, Maze M (1988) Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic α2 adrenergic receptor. Anesthesiology 69: 818823
Snapir A, Posti J, Kentala E et al. (2006) Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects. Anesthesiology 105: 902–910
Talke P, Chen R, Thomas B et al. (2000) The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg 90: 834–839
Venn RM, Hell J, Grounds RM (2000) Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Critical Care 4: 302–308
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Busley, R. (2012). Alpha2-Agonisten. In: Rossaint, R., Werner, C., Zwißler, B. (eds) Die Anästhesiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21125-6_15
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