Bispecific Antibodies for Diagnostic Applications

  • Archana Parashar
  • Susmita Sarkar
  • Advaita Ganguly
  • Sai Kiran Sharma
  • Mavanur R. SureshEmail author


Bispecific monoclonal antibodies (BsMAb) are unique engineered macromolecules that have two different pre-determined binding specificities. Their ability to simultaneously bind to a specific antigen and a given detection moiety enables them to function as excellent bifunctional immunoprobes in diagnostic assays. BsMAb are being exploited for the development of simple, rapid, and highly sensitive immunoassays for diagnosis of bacterial and viral infectious diseases. This chapter describes the use of BsMAb for the detection of Mycobacterium tuberculosis, Escherichia coli O157:H7, Bordetella pertussis, Severe Acute Respiratory Syndrome coronavirus, and Dengue virus. Further, BsMAb have been utilized for diagnosis of various types of cancers. The use of BsMAb in detection of prostate cancer and in cancer diagnostic imaging is also discussed.


Severe Acute Respiratory Syndrome Dengue Virus Tumor Uptake Severe Acute Respiratory Syndrome Bordetella Pertussis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Archana Parashar
    • 1
  • Susmita Sarkar
    • 1
  • Advaita Ganguly
    • 1
  • Sai Kiran Sharma
    • 1
  • Mavanur R. Suresh
    • 1
    Email author
  1. 1.Faculty of Pharmacy and Pharmaceutical SciencesUniversity of AlbertaEdmontonCanada

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