Bispecific Antibodies for the Retargeting of Cytokines

  • Bruno RobertEmail author
  • Christel Larbouret
  • David Azria
  • Jean-Pierre Mach
  • André Pèlegrin


The use of cytokines as adjuvant for different forms of cancer therapy represents one of the most promising areas of applied cancer research (Seruga et al.2008). As examples, Interleukin-2 is now been a classical treatment for renal cell carcinoma (FDA approved in 1992) and always evaluated for other cancer immunotherapy, interferon α for melanoma therapy (FDA approved in 1995) and others, such as IL-15 emerged as good candidate since IL-15 was ranked 1st/124 immunomodulatory drugs in clinical and preclinical trials to treat cancer by an NCI consortium (Cheever 2008).


Isolate Limb Perfusion Tumor Growth Delay Bispecific Antibody Tumor Blood Flow Murine Colon Carcinoma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Bruno Robert
    • 1
    Email author
  • Christel Larbouret
    • 1
  • David Azria
    • 1
  • Jean-Pierre Mach
    • 2
  • André Pèlegrin
    • 1
  1. 1.IRCM-Institut de Recherche en Cancérologie de Montpellier, Université MontpellierI, CRLC Val d’Aurelle-Paul LamarqueMontpellier, Cedex 5France
  2. 2.Department of BiochemistryUniversity of LausanneEpalingesSwitzerland

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