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Anti-VEGF-Therapie: Grundlagen und Substanzen

  • Salvatore Grisanti
  • Julia Lüke
  • Swaantje Peters

Zusammenfassung

Die Angiogenese ist ein physiologischer und lebensnotwendiger Prozess. Unter bestimmten Umständen kann dieser aber auch Ausdruck krankhafter Mechanismen sein. Man spricht dann von pathologischen Neovaskularisationen. Diese können im Rahmen neoplastischer Prozesse auftreten. In den meisten Fällen handelt es sich aber um ein reaktives Ereignis auf ein sich veränderndes Milieu. Hierzu zählen insbesondere hypoxische und entzündliche Vorgänge. Neovaskularisationen am Auge wirken sich durch die besondere Anatomie und Funktion des Organs meistens funktionsbeeinträchtigend aus und können letztendlich zur Erblindung oder Verlust des Auges führen. Zahlreiche Studien weisen den Faktor VEGF (»vascular endothelial growth factor«) als potenten Stimulator okulärer Neovaskularisationen aus.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Salvatore Grisanti
    • 1
  • Julia Lüke
    • 1
  • Swaantje Peters
    • 1
  1. 1.Klinik für AugenheilkundeUniversitätsklinikum Schleswig-HolsteinLübeck

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