Abstract
Teledermatopathology may involve real-time transmission of images from distant locations to consulting pathologists by the remote manipulation of a robotic microscope. Alternatively, the static store-and-forward (SAF) option involves the single file transmission of subjectively preselected and captured areas of microscopic images by a referring physician. The recent introduction of virtual slide systems (VSS) involves the digitization of whole slides at high resolution thus enabling the user to view any part of the specimen at any magnification. Such technology has surmounted previous restrictions caused by the size of preselected areas and specimen sampling for telepathology. In terms of client access, these VSS may be stored on a virtual slide (VS) server, made available on the web for remote consultation by pathologists via an integrated VS client network.
Despite SAF teledermatopathology being the most frequently used and less expensive approach to teledermatopathology, VSS represents the future in this discipline. The recent pilot studies suggest that the use of remote expert consultants in diagnostic dermatopathology can be integrated into daily routine, teleconsultation and teleteaching. The new technology enables rapid and reproducible diagnoses, but despite its usability, VSS are not completely feasible for teledermatopathology of inflammatory skin diseases as the performance seems to be influenced by the availability of complete clinical data. Improvements in the diagnostic facility will no doubt follow from further development of the VSS, the slide processor and of course training in the use virtual microscope. Undoubtedly as technology becomes even more sophisticated in the future VSS will overcome the present drawbacks and find its place in all facets of teledermatopathology.
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References
Morgan MB, Tannenbaum M, Smoller BR (2003) Telepathology in the diagnosis of routine dermatopathologic entities. Arch Dermatol 139:637–640
Cross SS, Dennis T, Start RD (2002) Telepathology: current status and future prospects in diagnostic histopathology. Histopathology 41:91–109
Weinstein RS, Descour MR, Liang C et al (2001) Telepathology overview: from concept to implementation. Hum Pathol 32:1283–1299
Glatz-Krieger K, Glatz D, Mihatsch MJ (2003) Virtual slides: high-quality demand, physical limitations, and affordability. Hum Pathol 34:968–974
Weinstein RS, Descour MR, Liang C et al (2004) An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study. Hum Pathol 35:1303–1314
DeAgustín D, Sanmartín J, Varela-Centelles P et al (2008) Technological bases for teledermatopathology: state of the art. Semin Cutan Med Surg 27:25–31
Pak HS (2002) Teledermatology and teledermatopathology. Semin Cutan Med Surg 21:179–189
Black-Schaffer S, Flotte TJ (2001) Teledermatopathology. Adv Dermatol 17:325–338
Weinstein LJ, Epstein JI, Edlow D et al (1997) Static image analysis of skin specimens: the application of telepathology to frozen section evaluation. Hum Pathol 28:30–35
Dawson PJ, Johnson JG, Edgemon LJ et al (2000) Outpatient frozen sections by telepathology in a Veterans Administration medical center. Hum Pathol 31:786–788
Okada DH, Binder SW, Felten CL et al (1999) “Virtual microscopy” and the internet as telepathology consultation tools: diagnostic accuracy in evaluating melanocytic skin lesions. Am J Dermatopathol 21:525–531
Ferrara G, Argenziano G, Cerroni L et al (2004) A pilot study of a combined dermoscopic-pathological approach to the telediagnosis of melanocytic skin neoplasms. J Telemed Telecare 10:34–38
Della Mea V, Puglisi F, Forti S et al (1997) Expert pathology consultation through the Internet: melanoma versus benign melanocytic tumours. J Telemed Telecare 3(suppl 1):17–19
Piccolo D, Soyer HP, Burgdorf W et al (2002) Concordance between telepathologic diagnosis and conventional histopathologic diagnosis: a multiobserver store-and-forward study on 20 skin specimens. Arch Dermatol 138:53–58
Berman B, Elgart GW, Burdick AE (1997) Dermatopathology via a still-image telemedicine system: diagnostic concordance with direct microscopy. Telemed J 3:27–32
Weinstein RS (2005) Innovations in medical imaging and virtual microscopy. Hum Pathol 36:317–319
Glatz-Krieger K, Glatz D, Mihatsch MJ (2006) Virtual microscopy: first applications. Pathologe 27:469–476
Helin H, Lundin M, Lundin J et al (2005) Web-based virtual microscopy in teaching and standardizing Gleason grading. Hum Pathol 36:381–386
Dee FR, Lehman JM, Consoer D et al (2003) Implementation of virtual microscope slides in the annual pathobiology of cancer workshop laboratory. Hum Pathol 34:430–436
Molnar B, Berczi L, Diczhazy C et al (2003) Digital slide and virtual microscopy based routine and telepathology evaluation of routine gastrointestinal biopsy specimens. J Clin Pathol 56:433–438
Li X, Liu J, Xu H et al (2007) A feasibility study of virtual slides in surgical pathology in China. Hum Pathol 38: 1842–1848
Costello SS, Johnston DJ, Dervan PA, O’Shea DG (2003) Development and evaluation of the virtual pathology slide: a new tool in telepathology. J Med Internet Res 5:e11
Johnston DJ, Costello SP, Dervan PA, O’Shea DG (2005) Development and preliminary evaluation of the VPS ReplaySuite: a virtual double-headed microscope for pathology. BMC Med Inform Decis Mak 5:10
Gilbertson JR, Ho J, Anthony L et al (2006) Primary histologic diagnosis using automated whole slide imaging: a validation study. BMC Clin Pathol 6:4
Furness P (2007) A randomized controlled trial of the diagnostic accuracy of internet-based telepathology compared with conventional microscopy. Histopathology 50: 266–273
Leinweber B, Massone C, Kodama K et al (2006) Teledermatopathology: a controlled study about diagnostic validity and technical requirements for digital transmission. Am J Dermatopathol 28:413–416
KS400 Imaging System Release 3.0. CarlZeissVision, Munich; 1997
Massone C, Soyer HP, Lozzi GP et al (2007) Feasibility and diagnostic agreement in teledermatopathology using a virtual slide system. Hum Pathol 38:546–554
Massone C, Soyer HP, Hofmann-Wellenhof R et al (2006) Two years’ experience with Web-based teleconsulting in dermatology. J Telemed Telecare 12:83–87
Soyer HP, Hofmann-Wellenhof R, Massone C et al (2005) Telederm.org: freely available online consultations in dermatology. PLoS Med 2:e87
Cerroni L, Argenyi Z, Cerio R et al (2010) Influence of evaluation of clinical pictures on the histopathologic diagnosis of inflammatory skin disorders. J Am Acad Dermatol 63: 647–652
Nielsen PS, Lindebjerg J, Rasmussen J et al (2010) Virtual microscopy: an evaluation of its validity and diagnostic performance in routine histologic diagnosis of skin tumors. Hum Pathol 41:1770–1776
Lundin M, Lundin J, Helin H, Isola J (2004) A digital atlas of breast histopathology: an application of web based virtual microscopy. J Clin Pathol 57:1288–1291
Schrader T, Niepage S, Leuthold T et al (2006) The diagnostic path, a useful visualisation tool in virtual microscopy. Diagn Pathol 1:40
Boutonnat J, Paulin C, Faure C et al (2006) A pilot study in two French medical schools for teaching histology using virtual microscopy. Morphologie 90:21–25
Kumar RK, Velan GM, Korell SO et al (2004) Virtual microscopy for learning and assessment in pathology. J Pathol 204:613–618
Fujita K, Crowley RS (2003) The virtual slide set – a curriculum development system for digital microscopy. AMIA Annu Symp Proc: 846
Mea VD, Bortolotti N, Beltrami CA (2009) eSlide suite: an open source software system for whole slide imaging. J Clin Pathol 62:749–751
Klock C, Gomes Rde P (2008) Web conferencing systems: Skype and MSN in telepathology. Diagn Pathol 15(3 suppl 1):S13
López AM, Graham AR, Barker GP et al (2009) Virtual slide telepathology enables an innovative telehealth rapid breast care clinic. Hum Pathol 40:1082–1091
Góngora Jará H, Barcelo HA (2008) Telepathology and continuous education: important tools for pathologists of developing countries. Diagn Pathol 15(3 suppl 1):S24
Massone C, Brunasso AM, Campbell TM, Soyer HP (2008) State of the art of teledermatopathology. Am J Dermatopathol 30:446–450
Massone C, Wurm EM, Soyer HP (2008) Teledermatology. G Ital Dermatol Venereol 143:213–218
Massone C, Wurm EM, Hofmann-Wellenhof R, Soyer HP (2008) Teledermatology: an update. Semin Cutan Med Surg 27:101–105
Weinstein RS, Graham AR, Richter LC et al (2009) Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future. Hum Pathol 40:1057–1069
Wienert S, Beil M, Saeger K et al (2009) Integration and acceleration of virtual microscopy as the key to successful implementation into the routine diagnostic process. Diagn Pathol 9(4):3
Dee FR (2009) Virtual microscopy in pathology education. Hum Pathol 40:1112–1121
Leung ST, Kaplan KJ (2009) Medicolegal aspects of telepathology. Hum Pathol 40:1137–1142
Krupinski EA (2009) Virtual slide telepathology workstation of the future: lessons learned from teleradiology. Hum Pathol 40:1100–1111
Graham AR, Bhattacharyya AK, Scott KM et al (2009) Virtual slide telepathology for an academic teaching hospital surgical pathology quality assurance program. Hum Pathol 40:1129–1136
Koch LH, Lampros JN, Delong LK et al (2009) Randomized comparison of virtual microscopy and traditional microscopy in diagnostic accuracy among dermatology and pathology residents. Hum Pathol 40:662–667
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Massone, C., Brunasso, A.M.G., Biscak, T.M., Soyer, H.P. (2012). Teledermatopathology. In: Soyer, H., Binder, M., Smith, A., Wurm, E. (eds) Telemedicine in Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20801-0_7
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