Skip to main content

Teledermatopathology

  • Chapter
  • First Online:
Telemedicine in Dermatology

Abstract

Teledermatopathology may involve real-time transmission of images from distant locations to consulting pathologists by the remote manipulation of a robotic microscope. Alternatively, the static store-and-forward (SAF) option involves the single file transmission of subjectively preselected and captured areas of microscopic images by a referring physician. The recent introduction of virtual slide systems (VSS) involves the digitization of whole slides at high resolution thus enabling the user to view any part of the specimen at any magnification. Such technology has surmounted previous restrictions caused by the size of preselected areas and specimen sampling for telepathology. In terms of client access, these VSS may be stored on a virtual slide (VS) server, made available on the web for remote consultation by pathologists via an integrated VS client network.

Despite SAF teledermatopathology being the most frequently used and less expensive approach to teledermatopathology, VSS represents the future in this discipline. The recent pilot studies suggest that the use of remote expert consultants in diagnostic dermatopathology can be integrated into daily routine, teleconsultation and teleteaching. The new technology enables rapid and reproducible diagnoses, but despite its usability, VSS are not completely feasible for teledermatopathology of inflammatory skin diseases as the performance seems to be influenced by the availability of complete clinical data. Improvements in the diagnostic facility will no doubt follow from further development of the VSS, the slide processor and of course training in the use virtual microscope. Undoubtedly as technology becomes even more sophisticated in the future VSS will overcome the present drawbacks and find its place in all facets of teledermatopathology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Morgan MB, Tannenbaum M, Smoller BR (2003) Telepathology in the diagnosis of routine dermatopathologic entities. Arch Dermatol 139:637–640

    Article  PubMed  Google Scholar 

  2. Cross SS, Dennis T, Start RD (2002) Telepathology: current status and future prospects in diagnostic histopathology. Histopathology 41:91–109

    Article  PubMed  CAS  Google Scholar 

  3. Weinstein RS, Descour MR, Liang C et al (2001) Telepathology overview: from concept to implementation. Hum Pathol 32:1283–1299

    Article  PubMed  CAS  Google Scholar 

  4. Glatz-Krieger K, Glatz D, Mihatsch MJ (2003) Virtual slides: high-quality demand, physical limitations, and affordability. Hum Pathol 34:968–974

    Article  PubMed  Google Scholar 

  5. Weinstein RS, Descour MR, Liang C et al (2004) An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study. Hum Pathol 35:1303–1314

    Article  PubMed  Google Scholar 

  6. DeAgustín D, Sanmartín J, Varela-Centelles P et al (2008) Technological bases for teledermatopathology: state of the art. Semin Cutan Med Surg 27:25–31

    Article  PubMed  Google Scholar 

  7. Pak HS (2002) Teledermatology and teledermatopathology. Semin Cutan Med Surg 21:179–189

    Article  PubMed  Google Scholar 

  8. Black-Schaffer S, Flotte TJ (2001) Teledermatopathology. Adv Dermatol 17:325–338

    PubMed  CAS  Google Scholar 

  9. Weinstein LJ, Epstein JI, Edlow D et al (1997) Static image analysis of skin specimens: the application of telepathology to frozen section evaluation. Hum Pathol 28:30–35

    Article  PubMed  CAS  Google Scholar 

  10. Dawson PJ, Johnson JG, Edgemon LJ et al (2000) Outpatient frozen sections by telepathology in a Veterans Administration medical center. Hum Pathol 31:786–788

    Article  PubMed  CAS  Google Scholar 

  11. Okada DH, Binder SW, Felten CL et al (1999) “Virtual microscopy” and the internet as telepathology consultation tools: diagnostic accuracy in evaluating melanocytic skin lesions. Am J Dermatopathol 21:525–531

    Article  PubMed  CAS  Google Scholar 

  12. Ferrara G, Argenziano G, Cerroni L et al (2004) A pilot study of a combined dermoscopic-pathological approach to the telediagnosis of melanocytic skin neoplasms. J Telemed Telecare 10:34–38

    Article  PubMed  Google Scholar 

  13. Della Mea V, Puglisi F, Forti S et al (1997) Expert pathology consultation through the Internet: melanoma versus benign melanocytic tumours. J Telemed Telecare 3(suppl 1):17–19

    PubMed  Google Scholar 

  14. Piccolo D, Soyer HP, Burgdorf W et al (2002) Concordance between telepathologic diagnosis and conventional histopathologic diagnosis: a multiobserver store-and-forward study on 20 skin specimens. Arch Dermatol 138:53–58

    Article  PubMed  CAS  Google Scholar 

  15. Berman B, Elgart GW, Burdick AE (1997) Dermatopathology via a still-image telemedicine system: diagnostic concordance with direct microscopy. Telemed J 3:27–32

    Article  PubMed  CAS  Google Scholar 

  16. Weinstein RS (2005) Innovations in medical imaging and virtual microscopy. Hum Pathol 36:317–319

    Article  PubMed  Google Scholar 

  17. Glatz-Krieger K, Glatz D, Mihatsch MJ (2006) Virtual microscopy: first applications. Pathologe 27:469–476

    Article  PubMed  CAS  Google Scholar 

  18. Helin H, Lundin M, Lundin J et al (2005) Web-based virtual microscopy in teaching and standardizing Gleason grading. Hum Pathol 36:381–386

    Article  PubMed  Google Scholar 

  19. Dee FR, Lehman JM, Consoer D et al (2003) Implementation of virtual microscope slides in the annual pathobiology of cancer workshop laboratory. Hum Pathol 34:430–436

    Article  PubMed  Google Scholar 

  20. Molnar B, Berczi L, Diczhazy C et al (2003) Digital slide and virtual microscopy based routine and telepathology evaluation of routine gastrointestinal biopsy specimens. J Clin Pathol 56:433–438

    Article  PubMed  CAS  Google Scholar 

  21. Li X, Liu J, Xu H et al (2007) A feasibility study of virtual slides in surgical pathology in China. Hum Pathol 38: 1842–1848

    Article  PubMed  Google Scholar 

  22. Costello SS, Johnston DJ, Dervan PA, O’Shea DG (2003) Development and evaluation of the virtual pathology slide: a new tool in telepathology. J Med Internet Res 5:e11

    Article  PubMed  Google Scholar 

  23. Johnston DJ, Costello SP, Dervan PA, O’Shea DG (2005) Development and preliminary evaluation of the VPS ReplaySuite: a virtual double-headed microscope for pathology. BMC Med Inform Decis Mak 5:10

    Article  PubMed  Google Scholar 

  24. Gilbertson JR, Ho J, Anthony L et al (2006) Primary histologic diagnosis using automated whole slide imaging: a validation study. BMC Clin Pathol 6:4

    Article  PubMed  Google Scholar 

  25. Furness P (2007) A randomized controlled trial of the diagnostic accuracy of internet-based telepathology compared with conventional microscopy. Histopathology 50: 266–273

    Article  PubMed  CAS  Google Scholar 

  26. Leinweber B, Massone C, Kodama K et al (2006) Teledermatopathology: a controlled study about diagnostic validity and technical requirements for digital transmission. Am J Dermatopathol 28:413–416

    Article  PubMed  Google Scholar 

  27. KS400 Imaging System Release 3.0. CarlZeissVision, Munich; 1997

    Google Scholar 

  28. Massone C, Soyer HP, Lozzi GP et al (2007) Feasibility and diagnostic agreement in teledermatopathology using a virtual slide system. Hum Pathol 38:546–554

    Article  PubMed  Google Scholar 

  29. Massone C, Soyer HP, Hofmann-Wellenhof R et al (2006) Two years’ experience with Web-based teleconsulting in dermatology. J Telemed Telecare 12:83–87

    Article  PubMed  CAS  Google Scholar 

  30. Soyer HP, Hofmann-Wellenhof R, Massone C et al (2005) Telederm.org: freely available online consultations in dermatology. PLoS Med 2:e87

    Article  PubMed  Google Scholar 

  31. Cerroni L, Argenyi Z, Cerio R et al (2010) Influence of evaluation of clinical pictures on the histopathologic diagnosis of inflammatory skin disorders. J Am Acad Dermatol 63: 647–652

    Article  PubMed  Google Scholar 

  32. Nielsen PS, Lindebjerg J, Rasmussen J et al (2010) Virtual microscopy: an evaluation of its validity and diagnostic performance in routine histologic diagnosis of skin tumors. Hum Pathol 41:1770–1776

    Article  PubMed  Google Scholar 

  33. Lundin M, Lundin J, Helin H, Isola J (2004) A digital atlas of breast histopathology: an application of web based virtual microscopy. J Clin Pathol 57:1288–1291

    Article  PubMed  CAS  Google Scholar 

  34. Schrader T, Niepage S, Leuthold T et al (2006) The diagnostic path, a useful visualisation tool in virtual microscopy. Diagn Pathol 1:40

    Article  PubMed  Google Scholar 

  35. Boutonnat J, Paulin C, Faure C et al (2006) A pilot study in two French medical schools for teaching histology using virtual microscopy. Morphologie 90:21–25

    Article  PubMed  CAS  Google Scholar 

  36. Kumar RK, Velan GM, Korell SO et al (2004) Virtual microscopy for learning and assessment in pathology. J Pathol 204:613–618

    Article  PubMed  Google Scholar 

  37. Fujita K, Crowley RS (2003) The virtual slide set – a curriculum development system for digital microscopy. AMIA Annu Symp Proc: 846

    Google Scholar 

  38. Mea VD, Bortolotti N, Beltrami CA (2009) eSlide suite: an open source software system for whole slide imaging. J Clin Pathol 62:749–751

    Article  PubMed  Google Scholar 

  39. Klock C, Gomes Rde P (2008) Web conferencing systems: Skype and MSN in telepathology. Diagn Pathol 15(3 suppl 1):S13

    Article  Google Scholar 

  40. López AM, Graham AR, Barker GP et al (2009) Virtual slide telepathology enables an innovative telehealth rapid breast care clinic. Hum Pathol 40:1082–1091

    Article  PubMed  Google Scholar 

  41. Góngora Jará H, Barcelo HA (2008) Telepathology and continuous education: important tools for pathologists of developing countries. Diagn Pathol 15(3 suppl 1):S24

    Article  Google Scholar 

  42. Massone C, Brunasso AM, Campbell TM, Soyer HP (2008) State of the art of teledermatopathology. Am J Dermatopathol 30:446–450

    Article  PubMed  Google Scholar 

  43. Massone C, Wurm EM, Soyer HP (2008) Teledermatology. G Ital Dermatol Venereol 143:213–218

    PubMed  CAS  Google Scholar 

  44. Massone C, Wurm EM, Hofmann-Wellenhof R, Soyer HP (2008) Teledermatology: an update. Semin Cutan Med Surg 27:101–105

    Article  PubMed  CAS  Google Scholar 

  45. Weinstein RS, Graham AR, Richter LC et al (2009) Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future. Hum Pathol 40:1057–1069

    Article  PubMed  Google Scholar 

  46. Wienert S, Beil M, Saeger K et al (2009) Integration and acceleration of virtual microscopy as the key to successful implementation into the routine diagnostic process. Diagn Pathol 9(4):3

    Article  Google Scholar 

  47. Dee FR (2009) Virtual microscopy in pathology education. Hum Pathol 40:1112–1121

    Article  PubMed  Google Scholar 

  48. Leung ST, Kaplan KJ (2009) Medicolegal aspects of telepathology. Hum Pathol 40:1137–1142

    Article  PubMed  Google Scholar 

  49. Krupinski EA (2009) Virtual slide telepathology workstation of the future: lessons learned from teleradiology. Hum Pathol 40:1100–1111

    Article  PubMed  Google Scholar 

  50. Graham AR, Bhattacharyya AK, Scott KM et al (2009) Virtual slide telepathology for an academic teaching hospital surgical pathology quality assurance program. Hum Pathol 40:1129–1136

    Article  PubMed  Google Scholar 

  51. Koch LH, Lampros JN, Delong LK et al (2009) Randomized comparison of virtual microscopy and traditional microscopy in diagnostic accuracy among dermatology and pathology residents. Hum Pathol 40:662–667

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cesare Massone .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Massone, C., Brunasso, A.M.G., Biscak, T.M., Soyer, H.P. (2012). Teledermatopathology. In: Soyer, H., Binder, M., Smith, A., Wurm, E. (eds) Telemedicine in Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20801-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-20801-0_7

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-20800-3

  • Online ISBN: 978-3-642-20801-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics