Multiple Small Supernumerary Marker Chromosomes



If a small supernumerary marker chromosome (sSMC) carrier has not only one (or more identical) centric sSMC derived from only one chromosome, but has two or more sSMC each derived from different chromosomes, one speaks of “multiple sSMC.” Most of the carriers of multiple sSMC are clinically abnormal and often severely impaired; there are only a few exceptions showing minor or no clinical signs or symptoms. One case report is provided in this chapter.


Mainstream School Neuromuscular Scoliosis Midface Hypoplasia Teacher Aide Small Supernumerary Marker Chromosome 
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  1. Liehr T (2011a) The sSMC homepage. Cited 10 Jan 2011
  2. Liehr T (2011a) Homepage on multicolor fluorescence in situ hybridization (mFISH) literature. Cited 10 Jan 2011
  3. Liehr T (2011b) Homepage on Cases with uniparental disomy (UPD). Cited 10 Jan 2011

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Institut für HumangenetikUniversitätsklinikum JenaJenaGermany

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