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Formation of Small Supernumerary Marker Chromosomes

  • Thomas Liehr
Chapter

Abstract

In general, not much is known about the exact mode of small supernumerary marker chromosome (sSMC) formation. Especially, when, why, and how during gametogenesis or embryogenesis an sSMC evolves is unclear. Nonetheless, for all kinds of sSMC shapes there are models for how they could be formed. These ideas are based in part on the finding that uniparental disomy and sSMC can show up together and on the observation that sSMC can evolve by incomplete trisomic rescue. Overall, an sSMC is formed by the combination of one or more rare events happening during gametogenesis or embryogenesis. This chapter sumarizes what is known on the formation of multiple sSMC compared with single sSMC, on inverted duplicated, centric minute-shaped, and ring-shaped sSMC evolution, on the mixtures of different sSMC shapes, and on centromeric activity of dicentric sSMC and breakpoint characteristics of sSMC.

Keywords

Karyotypic Evolution Derivative Chromosome Copy Number Variant Region Chromosome Fragmentation Active Centromere 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Institut für HumangenetikUniversitätsklinikum JenaJenaGermany

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