Inheritance of Small Supernumerary Marker Chromosomes



Here the mode of small supernumerary marker chromosome (sSMC) inheritance, i.e., if it is de novo or familial, is treated. Also sSMC and Bchromosomes are compared, as there are several similarities between them: both represent a heterogeneous collection of chromosomes added to the standard karyotype, both are small, both may consist of heterochromatic and/or euchromatic material, in both there is predominance of maternal transmission, and both demonstrate a tendency for mitotic instability.


Acrocentric Chromosome Fertility Problem Maternal Line Extra Chromosome Maternal Transmission 
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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Institut für HumangenetikUniversitätsklinikum JenaJenaGermany

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