Small Supernumerary Marker Chromosomes and Tumors



Marker chromosomes, also supernumerary ones, are regularly observed in tumor cytogenetics. However, they are mostly larger than a chromosome 20 of the same metaphase spread, and thus they are not small supernumerary marker chromosomes (sSMC) by definition. Additionally, and more importantly, these supernumerary marker chromosomes and sSMC in tumors are normally acquired and nonconstitutional. In other words, there is presently no correlation between sSMC and tumors.


Tumor Tissue Human Cancer Reproductive Medicine Marker Chromosome Metaphase Spread 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Institut für HumangenetikUniversitätsklinikum JenaJenaGermany

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