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Complex Small Supernumerary Marker Chromosomes

  • Thomas Liehr
Chapter

Abstract

Complex rearranged small supernumerary marker chromosomes (sSMC) consisting of parts from two or more different chromosomes can be formed. The most frequently observed complex sSMC are those present in Emanuel syndrome. Most often, complex sSMC have centric minute shape, followed by inverted duplication shape and ring shape. Chromosome 15 is most often involved. In most cases two chromosomes are involved, but there are also rare cases of complex rearranged sSMC in which only one chromosome or even three chromosomes are involved.

References

  1. Liehr T (2011a) The sSMC homepage. http://www.med.uni-jena.de/fish/sSMC/00START.htm. Cited 10 Jan 2011
  2. Liehr T, Mrasek K, Kosyakova N, Ogilvie CM, Vermeesch J, Trifonov V, Rubtsov N (2008a) Small supernumerary marker chromosomes (sSMC) in humans; are there B chromosomes hidden among them. Mol Cytogenet 1:12PubMedCrossRefGoogle Scholar
  3. Liehr T (2011a) Homepage on multicolor fluorescence in situ hybridization (mFISH) literature. http://www.med.uni-jena.de/fish/mFISH/mFISHlit.htm. Cited 10 Jan 2011
  4. Liehr T (2011b) Homepage on Cases with uniparental disomy (UPD). http://www.med.uni-jena.de/fish/sSMC/00START-UPD.htm. Cited 10 Jan 2011

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Institut für HumangenetikUniversitätsklinikum JenaJenaGermany

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