Adipose Stem Cells: From Liposuction to Adipose Tissue Engineering

  • Kotaro Yoshimura
  • Hitomi Eto
  • Harunosuke Kato
  • Kentaro Doi
  • Hirotaka Suga
Chapter

Abstract

A large volume of adipose tissue can be easily harvested through a well-established cosmetic surgical procedure, liposuction. Mesenchymal adherent stem/progenitor cells, similar to those from bone marrow, can be extracted from liposuction aspirates with a high efficiency and thus adipose tissue is now regarded as a potential source of adult stem/progenitor cells for regenerative medicine. Many features of adipose stem/progenitor cells, such as physiological functions and localization, have been clarified in the past decade. Adipose tissue turns over very slowly and its perivascular progenitor cells differentiate into new adipocytes, replacing dead adipocytes. The progenitor cells also play important roles in any types of adipose-tissue remodeling such as hyperplasia and atrophy of adipose tissue; as well as in incidental remodeling, such as post-injury repair. Therapeutic use of adipose stem/progenitor cells has been shown to promote angiogenesis and adipose-tissue regeneration.

Keywords

Adipose Tissue Hepatocyte Growth Factor Stromal Vascular Fraction Stromal Vascular Fraction Cell Deep Tissue Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ASCs

Adipose stem/progenitor cells

VECs

Vascular endothelial cells

SVF

Stromal vascular faction

PDGF

Platelet-derived growth factor

EGF

Epidermal growth factor

TGF-β

Transforming growth factor-β

b-FGF

Basic fibroblast growth factor

VEGF

Vascular endothelial growth factor

HGF

Hepatocyte growth factor

CAL

Cell-assisted lipotransfer

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Kotaro Yoshimura
    • 1
  • Hitomi Eto
    • 1
  • Harunosuke Kato
    • 1
  • Kentaro Doi
    • 1
  • Hirotaka Suga
    • 1
  1. 1.Department of Plastic SurgeryUniversity of Tokyo School of MedicineTokyoJapan

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