Adipose-Derived Stem Cells: Characterization and Application in Urology

Chapter

Abstract

Adipose-derived stem cells (ADSC) originate from the stromal vascular fraction of adipose tissue. Similar to other types of mesenchymal stem cells, these cells are closely associated with blood vessels, possibly residing in the tunica adventitia. They have the ability to differentiate into various cell types and secrete many trophic factors as well as immunosuppressive molecules. Thus, their therapeutic capacity is believed to be the result of these properties alone or in combination. ADSC have been shown to differentiate into epithelial-like cells when transplanted into kidneys. Their epithelial-like and smooth muscle differentiations in the bladder have also been observed. Treatment of stress urinary incontinence by injecting ADSC into the urethra has been demonstrated in animal models and human patients. Improvement of erectile function in animal models of different types of erectile dysfunction has also been reported.

Keywords

Mesenchymal Stem Cell Erectile Dysfunction Stress Urinary Incontinence Leydig Cell Erectile Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of Urology, Knuppe Molecular Urology Laboratory, School of MedicineUniversity of CaliforniaSan FranciscoUSA

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