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Adipose Stem Cells and Regenerative Medicine pp 193–207Cite as

Adipose-Derived Stem Cells: Characterization and Application in Urology

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Abstract

Adipose-derived stem cells (ADSC) originate from the stromal vascular fraction of adipose tissue. Similar to other types of mesenchymal stem cells, these cells are closely associated with blood vessels, possibly residing in the tunica adventitia. They have the ability to differentiate into various cell types and secrete many trophic factors as well as immunosuppressive molecules. Thus, their therapeutic capacity is believed to be the result of these properties alone or in combination. ADSC have been shown to differentiate into epithelial-like cells when transplanted into kidneys. Their epithelial-like and smooth muscle differentiations in the bladder have also been observed. Treatment of stress urinary incontinence by injecting ADSC into the urethra has been demonstrated in animal models and human patients. Improvement of erectile function in animal models of different types of erectile dysfunction has also been reported.

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Authors and Affiliations

  1. Department of Urology, Knuppe Molecular Urology Laboratory, School of Medicine, University of California, San Francisco, CA, 94143-0738, USA

    Ching-Shwun Lin & Tom F. Lue

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  1. Ching-Shwun Lin
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  2. Tom F. Lue
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Correspondence to Ching-Shwun Lin .

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  1. Plastic Surgery, Suchet 14 BD, Paris, 75016, France

    Yves-Gerard Illouz

  2. Regenerative Plastic Surgery Department, IASO General Hospital, Mesogeion Avenue 264, Athens, 15562, Greece

    Aris Sterodimas

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Lin, CS., Lue, T.F. (2011). Adipose-Derived Stem Cells: Characterization and Application in Urology. In: Illouz, YG., Sterodimas, A. (eds) Adipose Stem Cells and Regenerative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20012-0_18

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