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Stem Cell Based Cardioregeneration and Adipose Tissue

  • Atta BehfarEmail author
  • Andre Terzic
Chapter
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Abstract

Cardiovascular medicine has recently implemented multiple pre-clinical and clinical trials intended to identify a feasible and safe approach for cell-based heart repair. In the myocardium, several recent studies demonstrate the benefit of ATSCs to include direct contribution to neovasculogenesis and de novo cardiogenesis, in addition to indirect paracrine action for cardioprotection, neoangiogenesis, and neuron spindle formation. Furthermore, treatment with ATSCs has demonstrated a diminished propensity for arrhythmogenic risk without any evidence for uncontrolled growth, systemic complications, or tumorigenic change. Engrafted adipose stem cells improves the myocardial function with the capacity for contribution both via direct differentiation and indirect regenerative paracrine signaling in the host myocardial microenvironment. Adipose tissue resource holds great promise in providing the raw stem cell material to generate therapeutic products in the treatment of cardiovascular disease. However, due to the heterogenous nature of derived stem cells, further evaluation is needed to delineate the mechanism of stem cell benefit within the myocardium and implement next generation approaches such as linage specification and combinatorial stem cell therapy.

Keywords

Stem Cell Adult Stem Cell Bone Marrow Stem Cell Cardiac Stem Cell Adipose Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of MedicineMayo Clinic Center for Regenerative MedicineRochesterUSA

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