Stem Cells from Human Adipose Tissue: A New Tool for Pharmacological Studies and for Clinical Applications
Mesenchymal stem cells with a multilineage potential at the single cell level have been isolated from human adipose tissue. These cells, called human multipotent adipose-derived stem (hMADS) cells, have been established in culture and interestingly, maintain their characteristics with long-term passaging. The adipocyte differentiation of hMADS cells has been thoroughly studied and differentiated cells exhibit the unique feature of human adipocytes, making them a powerful tool for pharmacological studies. Potential applications of adipose-derived stem cells in medicine in the field of muscular dystrophy cell-based therapy will also be discussed. hMADS cells harbour a limited autonomous myogenic differentiation potential. However, this capacity can be increased by genetic modification. hMADS cells modified with MyoD, a master gene of embryonic myogenesis, have been shown in vitro and in vivo to be as myogenic as genuine myoblasts.
KeywordsSatellite Cell Duchenne Muscular Dystrophy Myogenic Differentiation Brown Adipocyte Human Adipocyte
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