Hybridization Dynamics Compensation in Microarray Experiments

  • Raul Malutan
  • Pedro Gómez Vilda
  • Ioana Berindan Neagoe
  • Monica Borda
Part of the Advances in Intelligent and Soft Computing book series (AINSC, volume 93)


The dynamics of the hybridization process in microarrays experiments is complex as thermodynamics factors influencing molecular interaction are still fields of important research and their effects are not fully taken into account in the estimation of genetic expression. In this paper an adaptive fitting is used to predict and regress microarray expression levels on a specific test probe to common thermodynamic conditions.


hybridization microarray regression 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Raul Malutan
    • 1
  • Pedro Gómez Vilda
    • 2
  • Ioana Berindan Neagoe
    • 3
  • Monica Borda
    • 1
  1. 1.Technical University of Cluj-NapocaCluj-NapocaRomania
  2. 2.Universidad Politécnica de MadridMadridSpain
  3. 3.The Oncology Institute “Prof. Dr. Ion Chiricuta”Cluj-NapocaRomania

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