Distances between Dinucleotides in the Human Genome
We developed a methodology to process DNA sequences based on the inter-dinucleotide distances and we characterized the inter-dinucleotide distance distributions of the human genome. The distance distribution of each dinucleotide was compared to the distance distribution of all the other dinucleotides using the Kullback-Leibler divergence. We found out that the divergence between the distribution of the distances of a dinucleotide and that of its reversed complement is very small, indicating that these distance distributions are very similar. This is an interesting finding that might give evidence of a stronger parity rule than the one provided by Chargaff’s second parity rule. Furthermore, we also compared the distance distribution of each dinucleotide to a reference distribution, that of a random sequence generated with the same dinucleotide abundances, revealing the CG dinucleotide as the one with the highest cumulative relative error for the first 60 distances.
KeywordsDistance Distribution Reference Distribution Parity Rule Reversed Complement Relative Frequency Distribution
Unable to display preview. Download preview PDF.
- 6.Glass, J.L., Thompson, R.F., Khulan, B., Figueroa, M.E., Olivier, E.N., Oakley, E.J., Van Zant, G., Bouhassira, E.E., Melnick, A., Golden, A., Fazzari, M.J., Greally, J.M.: CG dinucleotide clustering is a species-specific property of the genome. Nucleic Acids Research 35(20), 6798–6807 (2007)CrossRefGoogle Scholar