Zusammenfassung
Die Elektroenzephalographie (EEG) ermöglicht es, die Fluktuationen der kortikalen hirnelektrischen Aktivität (»Melodie der Hirnrinde«) zeitgetreu abzubilden. Nachdem erste EEG-Ableitungen in den Jahren 1924–1929 von dem Psychiater Hans Berger durchgeführt worden waren (Berger 1929), erlangte dieses Verfahren einen wichtigen Stellenwert in der Diagnostik und Verlaufsbeobachtung neuropsychiatrischer Erkrankungen und war lange Zeit das wichtigste technische Untersuchungsverfahren, um die klinische Diagnostik zu ergänzen. Mit den neuen Möglichkeiten der strukturellen Bildgebung wurde das EEG für Fragen der Hirnstrukturdiagnostik entbehrlich. Auch mit neuen Verfahren der Hirnfunktionsdiagnostik wie z. B. der funktionellen Magentresonanztomographie (fMRT), Positronenemissionstomographie (PET) oder Single-Photon-Emissionstomographie (SPECT) erwuchs dem EEG Konkurrenz.
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Literatur
Alper K, Schwartz KA, Kolts RL, Khan A (2007) Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports. Biol Psychiatry 62: 345–354
Amann BL, Pogarell O, Mergl R et al (2003) EEG abnormalities associated with antipsychotics: a comparison of quetiapine, olanzapine, haloperidol and healthy subjects. Hum Psychopharmacol 18: 641–646
Bauer G, Bauer R (1999) EEG, drug effects, and central nervous system poisoning. In: Niedermeyer E, Lopes da Silva FH (eds) Electroencephalography: basic principles, clinical applications, and related fields, 4th edn. Williams & Wilkins, Baltimore, MD, pp 671–691
Bellesi M, Passamonti L, Silvestrini M et al (2006) Non-convulsive status epilepticus during lithium treatment at therapeutic doses. Neurol Sci 26: 444–446
Berger H (1929) Über das Elektrenkephalogramm des Menschen. Archiv für Psychiatrie 87: 529–570
Boora K, Xu J, Hyatt J (2008) Encephalopathy with combined lithium-risperidone administration. Acta Psychiatr Scand 117: 394–395
Borowicz KK, Stepien K, Czuczwar SJ (2006) Fluoxetine enhances the anticonvulsant effects of conventional antiepileptic drugs in maximal electroshock seizures in mice. Pharmacol Rep 58: 83–90
Brenner RP (1991) Utility of EEG in delirium: past views and current practice. Int Psychogeriatr 3: 211–229
Bschor T, Müller-Oerlinghausen B, Ulrich G (2001) Decreased level of EEGvigilance in acute mania as a possible predictor for a rapid effect of methylphenidate: a case study. Clin Electroencephalogr 32: 36–39
Caviness JN, Evidente VG (2003) Cortical myoclonus during lithium exposure. Arch Neurol 60: 401–404
Centorrino F, Price BH, Tuttle M et al (2002) EEG abnormalities during treatment with typical and atypical antipsychotics. Am J Psychiatry 159: 109–115
De Gennaro L, Marzano C, Fratello F et al (2008) The electroencephalographic fingerprint of sleep is genetically determined: a twin study. Ann Neurol 64: 455–460
Dudra-Jastrzebska M, Andres-Mach MM, Luszczki JJ, Czuczwar SJ (2007) Mood disorders in patients with epilepsy. Pharmacol.Rep 59: 369–378
Ereshefsky L, Watanabe MD, Tran-Johnson TK (1989) Clozapine: an atypical antipsychotic agent. Clin Pharm 8: 691–709
Fink M (2002) EEG changes with antipsychotic drugs. Am J Psychiatry 159: 1439
Freudenreich O, Weiner RD, McEvoy JP (1997) Clozapine-induced electroencephalogram changes as a function of clozapine serum levels. Biol Psychiatry 42: 132–137
Gallinat J, Boetsch T, Padberg F et al (2000) Is the EEG helpful in diagnosing and monitoring lithium intoxication? A case report and review of the literature. Pharmacopsychiatry 33: 169–173
Grandjean EM, Aubry JM (2009) Lithium: updated human knowledge using an evidence-based approach: part III: clinical safety. CNS Drugs 23: 397–418
Gunther W, Baghai T, Naber D et al (1993) EEG alterations and seizures during treatment with clozapine. A retrospective study of 283 patients. Pharmacopsychiatry 26: 69–74
Habermeyer B, Hess M, Kozomara-Hocke P et al (2008) Lithium intoxications at normal serum levels. Psychiatr Prax 35: 198–200
Halgren E, Baudena P, Clarke JM et al (1995a) Intracerebral potentials to rare target and distractor auditory and visual stimuli. I. Superior temporal plane and parietal lobe. Electroencephalogr Clin Neurophysiol 94: 191–220
Halgren E, Baudena P, Clarke JM et al (1995b) Intracerebral potentials to rare target and distractor auditory and visual stimuli. II. Medial, lateral and posterior temporal lobe. Electroencephalogr Clin Neurophysiol 94: 229–250
Hansen N, Finzel M, Block F (2010) Antiepileptic drug-induced encephalopathy. Fortschr Neurol Psychiatr 78: 590–598-
Haring C, Neudorfer C, Schwitzer J et al (1994) EEG alterations in patients treated with clozapine in relation to plasma levels. Psychopharmacology (Berl) 114: 97–100
Hegerl U (1998) Neurophysiologische Untersuchungen in der Psychiatrie: EEG, EKP, Schlafpolygraphie, Motorik, autonome Funktionen. Springer, Wien
Hegerl U, Sander C, Olbrich S, Schoenknecht P (2009) Are psychostimulants a treatment option in mania? Pharmacopsychiatry 42: 169–174
Hegerl U, Himmerich H, Engmann B, Hensch T (2010) Mania and attentiondeficit/hyperactivity disorder: common symptomatology, common pathophysiology and common treatment? Curr Opin Psychiatry 23: 1–7
Hegerl U, Hensch T, Mulert C (2011a) Neurophysiologische Grundlagen psychischer Erkrankungen. In: Moller HJ, Laux G, Kapfhammer HP (Hrsg) Psychiatrie, Psychosomatik, Psychotherapie, 4. Aufl. Springer, Berlin Heidelberg New York Tokio, S 277–292
Hegerl U, Wilk K, Olbrich S et al (2011b) Hyperstable regulation of vigilance in patients with major depressive disorder. World J Biol Psychiatry, Epub ahead of print
Hesdorffer DC, Hauser WA, Olafsson E et al (2006) Depression and suicide attempt as risk factors for incident unprovoked seizures. Ann Neurol 59: 35–41
Juckel G (2003) Effekte von Psychopharmaka auf das EEG. Neurophysiol Lab 25: 89–105
Juckel G, Pogarell O, Augustin H et al (2007) Differential prediction of first clinical response to serotonergic and noradrenergic antidepressants using the loudness dependence of auditory evoked potentials in patients with major depressive disorder. J Clin Psychiatry 68: 1206–1212
Kanner AM (2008) The use of psychotropic drugs in epilepsy: what every neurologist should know. Semi–n Neurol 28: 379–388
Kaplan PW, Birbeck G (2006) Lithium-induced confusional states: nonconvulsive status epilepticus or triphasic encephalopathy? Epilepsia 47: 2071–2074
Kondziella D, Asztely F (2009) Don’t be afraid to treat depression in patients with epilepsy! Acta Neurol Scand 119: 75–80
Kumlien E, Lundberg PO (2010) Seizure risk associated with neuroactive drugs: data from the WHO adverse drug reactions database. Seizure 19: 69–73
Malow BA, Reese KB, Sato S et al (1994) Spectrum of EEG abnormalities during clozapine treatment. Electroencephalogr Clin Neurophysiol 91: 205–211
Mulert C, Jager L, Schmitt R et al (2004) Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and timecourse of brain activity in target detection. NeuroImage 22: 83–94
Mulert C, Juckel G, Giegling I et al (2006) A Ser9Gly polymorphism in the dopamine D3 receptor gene (DRD3) and event-related P300 potentials. Neuropsychopharmacology 31: 1335–1344
Mulert C, Juckel G, Brunnmeier M et al (2007) Prediction of treatment response in major depression: integration of concepts. J Affect Disord 98: 215–25
Pogarell O, Hegerl U (2011) Neurophysiologische Untersuchungsmethoden. In: Moller HJ, Laux G, Kapfhammer HP (Hrsg) Psychiatrie, Psychosomatik, Psychotherapie, 4. Aufl. Springer, Berlin Heidelberg New York Tokio, S 621–647
Pogarell O, Juckel G, Mulert C et al (2004) EEG abnormalities under treatment with atypical antipsychotics: effects of olanzapine and amisulpride as compared to haloperidol. Pharmacopsychiatry 37: 304–305
Pogarell O, Ehrentraut S, Ruther T et al (2005) Prolonged confusional state following electroconvulsive therapy–diagnostic clues from serial electroencephalography. Pharmacopsychiatry 38: 316–320
Pogarell O, Folkerts M, Hegerl U (2006a) Adverse neurological and neurotoxic effects of lithium therapy. In: Bauer M, Grof P, Muller-Oerlinghausen B (eds) Lithium in neuropsychiatry: the comprehensive guide. Taylor & Francis, London
Pogarell O, Hegerl U, Mulert C (2006b) Electroconvulsive therapy and nonconvulsive status epilepticus – response to anticonvulsants might solve the dilemma. Pharmacopsychiatry 39: 120
Pogarell O, Padberg F, Karch S et al (2011) Dopaminergic mechanisms of target detection – P300 event related potential and striatal dopamine. Psychiatry Res NI, in press
Risby ED, Epstein CM, Jewart RD et al (1995) Clozapine-induced EEG abnormalities and clinical response to clozapine. J Neuropsychiatry Clin Neurosci 7: 466–470
Saletu B, Anderer P, Stanek J, Saletu-Zyhlarz GM (2010) EEG-Mapping und EEG-Tomographie in der Neuropsychopharmakologie. In: Riederer PF, Laux G (Hrsg) Grundlagen der Neuropsychopharmakologie. Springer, Wien, S 109–123
Sander C, Arns M, Olbrich S, Hegerl U (2010). EEG-vigilance and response to stimulants in paediatric patients with attention deficit/hyperactivity disorder. Clin Neurophysiol 121: 1511–1518
Schoenknecht P, Olbrich S, Sander C et al (2010) Treatment of acute mania with modafinil monotherapy. Biol Psychiatry 67: e55–57
Schulz C, Mavrogiorgou P, Schroter A et al (2000) Lithium-induced EEG changes in patients with affective disorders. Neuropsychobiology 42(Suppl 1): 33–37
Segura-Bruna N, Rodriguez-Campello A, Puente V, Roquer J (2006) Valproateinduced hyperammonemic encephalopathy. Acta Neurol Scand 114: 1–7
Selvitelli MF, Walker LM, Schomer DL, Chang BS (2010) The relationship of interictal epileptiform discharges to clinical epilepsy severity: a study of routine electroencephalograms and review of the literature. J Clin Neurophysiol 27: 87–92
Sidhu KS, Balon R, Ajluni V, Boutros NN (2009) Standard EEG and the difficultto-assess mental status. Ann Clin Psychiatry 21: 103–108
Small JG, Milstein V, Malloy FW et al (1999) Clinical and quantitative EEG studies of mania. J Affect Disord 53: 217–224
So EL (2010) Interictal epileptiform discharges in persons without a history of seizures: what do they mean? J Clin Neurophysiol 27: 229–238
Sterr A, Padberg F, Amann B et al (2006) Electroencephalographic abnormalities associated with antidepressant treatment: a comparison of mirtazapine, venlafaxine, citalopram, reboxetine, and riptyline. J Clin Psychiatry 67: 325–326
Sundaram M, Hogan T, Hiscock M, Pillay N (1990) Factors affecting interictal spike discharges in adults with epilepsy. Electroencephalogr Clin Neurophysiol 75: 358–360
Thomas C, Hestermann U, Kopitz J et al (2008) Serum anticholinergic activity and cerebral cholinergic dysfunction: an EEG study in frail elderly with and without delirium. BMC Neurosci 9: 86
Van Beijsterveldt CE, Van Baal GC (2002) Twin and family studies of the human electroencephalogram: a review and a meta-analysis. Biol Psychol 61: 111–138
Welch J, Manschreck T, Redmond D (1994) Clozapine-induced seizures and EEG changes. J Neuropsychiatry Clin Neurosci 6: 250–256
Wilson WH, Claussen AM (1994) Seizures associated with clozapine treatment in a state hospital. J Clin Psychiatry 55: 184–188
Wirrell EC (2010) Prognostic significance of interictal epileptiform discharges in newly diagnosed seizure disorders. J Clin Neurophysiol 27: 239–248
Wong J, Delva N (2007) Clozapine-induced seizures: recognition and treatment. Can J Psychiatry 52: 457–463
Yilmaz I, Sezer Z, Kayir H, Uzbay TI (2007) Mirtazapine does not affect pentylenetetrazole-and maximal electroconvulsive shock-induced seizures in mice. Epilepsy Behav 11: 1–5
Zschocke S, Hansen H-C (2011) Klinische Elektroenzephalographie, 3. Aufl. Springer, Berlin Heidelberg New York Tokio
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Pogarell, O., Hensch, T., Hegerl, U. (2012). Elektroenzephalographie in der Psychopharmakotherapie. In: Gründer, G., Benkert, O. (eds) Handbuch der psychiatrischen Pharmakotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19844-1_39
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