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Zusammenfassung

Süchtiges Verhalten zählt zu den schwersten und häufigsten psychischen Erkrankungen unserer Zivilisation. Das starke Verlangen des Abhängigen nach der Droge (Craving; im Tier spricht man von einem ausgeprägten Drogensuchverhalten) wird zum Lebensmittelpunkt und zur zentralen Motivation seines Verhaltens. Damit geht zumeist die Entgleisung aus dem sozialen Umfeld einher; der Absturz ins gesellschaft liche Abseits ist häufig unvermeidbar. Die Folgen exzessiven Drogenkonsums zeigen sich auf dramatische Weise in der Entwicklung eines Suchtgedächtnisses – Veränderungen spezifischer neuronaler Strukturen im Gehirn des Süchtigen. Diese nach heutigem Kenntnisstand oft irreversiblen Veränderungen scheinen verantwortlich dafür, dass Süchtige auch nach jahrelanger Abstinenz rückfällig werden.

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Literatur

  • Chiamulera C, Valerio E, Tessari M (1995) Resumption of ethanol-seeking behaviour in rats. Behav Pharmacol 6: 32–39

    CAS  PubMed  Google Scholar 

  • De Wit H, Stewart J (1981) Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 79: 29–31

    Article  Google Scholar 

  • Galli G, Wolffgramm J (2004) Long-term voluntary D-amphetamine consumption and behavioral predictors for subsequent D-amphetamine addiction in rats. Drug Alcohol Depend 73(1): 51–60

    Article  CAS  PubMed  Google Scholar 

  • Jacobs EH, Spjker S, Verhoog CW et al (2002) Active heroin adminstration induces specific genomic responses in the nucleus accumbens shell. FASEB J 16: 1961–1963

    CAS  PubMed  Google Scholar 

  • Sanchis-Segura C, Spanagel R (2006) Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol 11: 2–38

    Article  PubMed  Google Scholar 

  • Shaham Y, Shalev U, Lu L et al (2003) The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology 168: 3–20

    Article  CAS  PubMed  Google Scholar 

  • Sommer W, Hyytiä P, Kiianmaa K (2006) The alcohol-preferring AA and alcohol-avoiding ANA rats: neurobiology of the regulation of alcohol drinking. Addict Biol 11: 289–309

    Article  PubMed  Google Scholar 

  • Spanagel R (2010) Are metabotropic glutamate receptors promising targets for the treatment of alcoholism? Biol Psychiatry 67: 798–799

    Article  PubMed  Google Scholar 

  • Spanagel R, Hölter SM (1999) Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism? Alcohol Alcohol 34: 231–243

    Article  CAS  PubMed  Google Scholar 

  • Spanagel R, Kiefer F (2008) Drugs for relapse prevention of alcoholism – 10 years of progress. Trends Pharmacol Sci 29: 109–115

    Article  CAS  PubMed  Google Scholar 

  • Spanagel R, Bartsch D, Brors B et al (2010) An integrated genome research network for studying the genetics of alcohol addiction. Addict Biol 15: 369–379

    Article  CAS  PubMed  Google Scholar 

  • Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL (2001) Relapse to cocaineseeking after hippocampal theta burst stimulation. Science 292: 1175–1178

    Article  CAS  PubMed  Google Scholar 

  • Weiss, F, Martin-Fardon R, Ciccocioppo R et al (2001) Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues. Neuropsychopharmacology 25: 361–372

    Article  CAS  PubMed  Google Scholar 

  • Wiens F, Zitzmann A, Lachance MA et al (2008) Chronic intake of fermented floral nectar by wild treeshrews. Proc Natl Acad Sci USA 105: 10426–10431

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Wolffgramm J, Heyne A (1995) From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat. Behav Brain Res 70: 77–94

    Article  CAS  PubMed  Google Scholar 

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Bachteler, D., Spanagel, R. (2012). Tiermodelle für abhängiges Verhalten. In: Gründer, G., Benkert, O. (eds) Handbuch der psychiatrischen Pharmakotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19844-1_23

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  • DOI: https://doi.org/10.1007/978-3-642-19844-1_23

  • Publisher Name: Springer, Berlin, Heidelberg

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